Article
Biochemistry & Molecular Biology
Ilona Faustova, Kaidi Moll, Ervin Valk, Mart Loog, Mihkel Ord
Summary: Cyclins not only activate CDK complexes, but also serve as docking scaffolds for CDK substrates and inhibitors. G1-cyclins in yeast play a specific role in promoting bud growth and polarization, essential for cell survival. The discovery of a specific docking motif in G1-cyclins expands our understanding of cyclin specificity mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Rafaela Fagundes, Leonardo K. Teixeira
Summary: DNA replication must be precisely controlled, and cell cycle transitions are regulated by the Cyclin-Dependent Kinases (CDKs) family. The Cyclin E/CDK2 complex controls cell cycle progression and DNA replication through phosphorylation of specific substrates in normal cycles, while its oncogenic activation causes replication stress and genomic instability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Laura S. Mazzitelli-Fuentes, Fernanda R. Roman, Julio R. Castillo Elias, Emilia B. Deleglise, Lucas A. Mongiat
Summary: Adult neurogenesis in specific pallial regions is increased during the learning process in adult zebrafish, with distinct critical periods. Labeled cells in these learning-sensitive regions decrease over time, but a fraction of them continues to proliferate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shristi Bhattarai, Bruna M. Sugita, Stefanne M. Bortoletto, Aline S. Fonseca, Luciane R. Cavalli, Ritu Aneja
Summary: TNBCs can be further classified into AR-positive and AR-negative subtypes, with AR-negative tumors showing higher levels of CNAs and a higher frequency of cases affected by CNAs. QNBCs and TNBCs exhibit similar CNAs in CIN25 and CA signatures, but QNBCs have higher expression levels of CIN25 and CA20 genes. miRNA profiling identified differentially expressed miRNAs associated with genomic instability, with eight miRNAs showing concordance of expression and copy number levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Katherine L. Taylor, Elizabeth J. Wade, Marta M. Wells, Charles S. Henry
Summary: The study investigates the relationship between mating song period and the genome in the Chrysoperla carnea-group lacewings. The findings suggest that decreased recombination plays a role in maintaining reproductive isolation between species.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Teng-Fei Xing, Yu-Long Li, Jin-Xian Liu
Summary: By comparing whole genome re-sequencing data of male and female clearhead icefish, female-specific genomic regions were identified, including a potential FOX1 gene associated with sex. The female-specific markers and rapid, cost-effective PCR-based genetic sex identification method could be useful for studying sex determination mechanisms in this species.
Article
Biochemistry & Molecular Biology
Julien Vibert, Olivier Saulnier, Celine Collin, Floriane Petit, Kyra J. E. Borgman, Jeromine Vigneau, Maud Gautier, Sakina Zaidi, Gaelle Pierron, Sarah Watson, Nadege Gruel, Clemence Henon, Sophie Postel-Vinay, Marc Deloger, Virginie Raynal, Sylvain Baulande, Karine Laud-Duval, Veronique Hill, Sandrine Grossetete, Florent Dingli, Damarys Loew, Jacob Torrejon, Olivier Ayrault, Martin F. Orth, Thomas G. P. Grunewald, Didier Surdez, Antoine Coulon, Joshua J. Waterfall, Olivier Delattre
Summary: This study identifies a new activity of aberrant transcription factors (TFs) in cancer, which is the transcription, processing, and translation of highly expressed multi-exonic transcripts from otherwise silent regions of the genome. These novel transcripts are specific to certain cancers characterized by gene fusions encoding oncogenic chimeric TFs.
Article
Biology
Xidong Mu, Yi Liu, Chao Liu, Chenxi Zhao, Ruihan Li, Xinxin You, Yexin Yang, Xuejie Wang, Yinchang Hu, Qiong Shi, Chao Bian
Summary: In this study, we sequenced the genomes of Asian arowana to discover molecular clues to its sex determination. We identified candidate genes and structural variations that may be associated with sex determination. This research provides valuable genetic resources for global aquarium fish research.
Article
Biochemistry & Molecular Biology
Hui Zhao, Zhe Chen, Hao Li, Yue-Hong Zhao, Qun Wang, Wei-Wei Li
Summary: This study demonstrates that bacteria can induce hemocyte proliferation in Chinese mitten crabs, and EsCsn5 plays a negative regulatory role in this process by controlling the degradation of EsCyclin E. Knockdown of EsCsn5 enhances hemocyte proliferation and reduces survival rate in crabs, leading to increased bacterial concentration in the hemolymph.
Article
Multidisciplinary Sciences
Emiliano Maiani, Giacomo Milletti, Francesca Nazio, Sos Gronbaek Holdgaard, Jirina Bartkova, Salvatore Rizza, Valentina Cianfanelli, Mar Lorente, Daniele Simoneschi, Miriam Di Marco, Pasquale D'Acunzo, Luca Di Leo, Rikke Rasmussen, Costanza Montagna, Marilena Raciti, Cristiano De Stefanis, Estibaliz Gabicagogeascoa, Gergely Rona, Nelida Salvador, Emanuela Pupo, Joanna Maria Merchut-Maya, Colin J. Daniel, Marianna Carinci, Valeriana Cesarini, Alfie O'sullivan, Yeon-Tae Jeong, Matteo Bordi, Francesco Russo, Silvia Campello, Angela Gallo, Giuseppe Filomeni, Letizia Lanzetti, Rosalie C. Sears, Petra Hamerlik, Armando Bartolazzi, Robert E. Hynds, David R. Pearce, Charles Swanton, Michele Pagano, Guillermo Velasco, Elena Papaleo, Daniela De Zio, Apolinar Maya-Mendoza, Franco Locatelli, Jiri Bartek, Francesco Cecconi
Summary: AMBRA1 has been identified as a key regulator in cell cycle control, playing a crucial role in maintaining genomic integrity by regulating the abundance of D-type cyclins and facilitating the transition from G1 to S phase, thereby preventing replication stress. The findings suggest that CHK1 kinase could be a potential therapeutic target in AMBRA1-deficient tumors, highlighting the importance of the AMBRA1-cyclin D pathway in regulating cell cycle and genomic stability in embryonic development and tumorigenesis.
Editorial Material
Multidisciplinary Sciences
Eucharist Kun, Vagheesh M. Narasimhan
Summary: Scientists have mapped the regions of the human genome that rapidly evolved after the divergence of humans and chimpanzees. These regions contain unique genomic elements linked to neurodevelopment and disease.
Article
Biochemistry & Molecular Biology
Zhi Zhang, Huiqing Wen, Bangjian Peng, Jun Weng, Fanhong Zeng
Summary: The study found that CDKN2A can reduce the expression of PIAS1 by enhancing its SUMOylation, thereby inhibiting lipogenesis in fatty liver. PRMT1 can downregulate CFLAR by triggering its ubiquitination, impacting the phosphorylation of JNK. Silencing CDKN2A can prevent lipogenesis and fat accumulation in fatty liver by affecting PRMT1-dependent ubiquitination and JNK phosphorylation.
Article
Biochemical Research Methods
Luca Denti, Parsoa Khorsand, Paola Bonizzoni, Fereydoun Hormozdiari, Rayan Chikhi
Summary: Structural variants (SVs) contribute to sequence variability in genomes and are significant in human genomics and precision medicine. However, due to the complexities of the human genome, SV discovery in individuals has been challenging. The introduction of low-error long-read sequencing technologies, such as PacBio HiFi, may provide a solution to these challenges.
Article
Biochemistry & Molecular Biology
Carla Guillen-Pingarron, Pedro M. Guillem-Gloria, Anjali Soni, Gloria Ruiz-Gomez, Martina Augsburg, Frank Buchholz, Massimiliano Anselmi, M. Teresa Pisabarro
Summary: Protein intrinsically disordered regions (IDRs) play crucial roles in molecular recognition and regulation. By investigating the disordered N-terminal tail of Cre enzyme, the study provides mechanistic insights into the relationship between structural disorder and protein function. The findings offer new understanding of the functional implications of IDRs and their potential applications in biotechnology and genomic medicine.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Natalie R. Hofmeister, Katarina C. Stuart, Wesley C. Warren, Scott J. Werner, Melissa Bateson, Gregory F. Ball, Katherine L. Buchanan, David W. Burt, Adam P. A. Cardilini, Phillip Cassey, Tim De Meyer, Julia George, Simone L. Meddle, Hannah M. Rowland, Craig D. H. Sherman, William B. Sherwin, Wim Vanden Berghe, Lee Ann Rollins, David F. Clayton
Summary: This study investigates how demographic processes and rapid evolution interact to generate genetic variation in invasive species. The study compares whole-genome sequences of native and independently introduced populations of European starlings, revealing genetic differentiation even on a short evolutionary timescale. The findings suggest that multiple evolutionary mechanisms, including demographic booms and potential inversions, contribute to differentiation during the invasion process.
Article
Statistics & Probability
Sung Won Han, Sunghoon Park, Hua Zhong, Eun-Seok Ryu, Pei Wang, Sehee Jung, Jayeon Lim, Jeewhan Yoon, SungHwan Kim
Summary: Biological regulatory pathways are crucial for cancer therapy. This paper introduces a method called jDAG for estimating gene networks, which can identify common and distinct directed edges in joint data sets. Despite requiring longer computational times, the proposed jDAG outperforms existing methods in simulation and case studies of breast cancer data sets.
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
(2021)
Article
Biochemistry & Molecular Biology
Yongchao Dou, Emily A. Kawaler, Daniel Cui Zhou, Marina A. Gritsenko, Chen Huang, Lili Blumenberg, Alla Karpova, Vladislav A. Petyuk, Sara R. Savage, Shankha Satpathy, Wenke Liu, Yige Wu, Chia-Feng Tsai, Bo Wen, Zhi Li, Song Cao, Jamie Moon, Zhiao Shi, MacIntosh Cornwell, Matthew A. Wyczalkowski, Rosalie K. Chu, Suhas Vasaikar, Hua Zhou, Qingsong Gao, Ronald J. Moore, Kai Li, Sunantha Sethuraman, Matthew E. Monroe, Rui Zhao, David Heiman, Karsten Krug, Karl Clauser, Ramani Kothadia, Yosef Maruvka, Alexander R. Pico, Amanda E. Oliphant, Emily L. Hoskins, Samuel L. Pugh, Sean J. I. Beecroft, David W. Adams, Jonathan C. Jarman, Andy Kong, Hui-Yin Chang, Boris Reva, Yuxing Liao, Dmitry Rykunov, Antonio Colaprico, Xi Steven Chen, Andrzej Czekanski, Marcin Jedryka, Rafa Matkowski, Maciej Wiznerowicz, Tara Hiltke, Emily Boja, Christopher R. Kinsinger, Mehdi Mesri, Ana I. Robles, Henry Rodriguez, David Mutch, Katherine Fuh, Matthew J. Ellis, Deborah DeLair, Mathangi Thiagarajan, D. R. Mani, Gad Getz, Michael Noble, Alexey I. Nesvizhskii, Pei Wang, Matthew L. Anderson, Douglas A. Levine, Richard D. Smith, Samuel H. Payne, Kelly V. Ruggles, Karin D. Rodland, Li Ding, Bing Zhang, Tao Liu, David Fenyo
Article
Oncology
Chu Chen, Pawadee Lohavanichbutr, Yuzheng Zhang, John R. Houck, Melissa P. Upton, Behnoush Abedi-Ardekani, Antonio Agudo, Wolfgang Ahrens, Laia Alemany, Devasena Anantharaman, David Conway, Neal D. Futran, Ivana Holcatova, Kathrin Guenther, Bo T. Hansen, Claire M. Healy, Doha Itani, Kristina Kjaerheim, Marcus M. Monroe, Peter J. Thomson, Benjamin L. Witt, Steven Nakoneshny, Lisa A. Peterson, Stephen M. Schwartz, Katie R. Zarins, Mia Hashibe, Paul Brennan, Laura S. Rozek, Gregory Wolf, Joseph C. Dort, Pei Wang
Article
Gastroenterology & Hepatology
Joana Torres, Francesca Petralia, Takahiro Sato, Pei Wang, Shannon E. Telesco, Rok Seon Choung, Richard Strauss, Xiao-Jun Li, Renee M. Laird, Ramiro L. Gutierrez, Chad K. Porter, Scott Plevy, Fred Princen, Joseph A. Murray, Mark S. Riddle, Jean-Frederic Colombel
Article
Biochemical Research Methods
Selim Kalayci, Francesca Petralia, Pei Wang, Zeynep H. Gumus
Article
Statistics & Probability
Haoran Li, Alexander Aue, Debashis Paul, Jie Peng, Pei Wang
ANNALS OF STATISTICS
(2020)
Article
Biochemistry & Molecular Biology
Michael A. Gillette, Shankha Satpathy, Song Cao, Saravana M. Dhanasekaran, Suhas V. Vasaikar, Karsten Krug, Francesca Petralia, Yize Li, Wen-Wei Liang, Boris Reva, Azra Krek, Jiayi Ji, Xiaoyu Song, Wenke Liu, Runyu Hong, Lijun Yao, Lili Blumenberg, Sara R. Savage, Michael C. Wendl, Bo Wen, Kai Li, Lauren C. Tang, Melanie A. MacMullan, Shayan C. Avanessian, M. Harry Kane, Chelsea J. Newton, MacIntosh Cornwell, Ramani B. Kothadia, Weiping Ma, Seungyeul Yoo, Rahul Mannan, Pankaj Vats, Chandan Kumar-Sinha, Emily A. Kawaler, Tatiana Omelchenko, Antonio Colaprico, Yifat Geffen, Yosef E. Maruvka, Felipe da Veiga Leprevost, Maciej Wiznerowicz, Zeynep H. Gumus, Rajwanth R. Veluswamy, Galen Hostetter, David Heiman, Matthew A. Wyczalkowski, Tara Hiltke, Mehdi Mesri, Christopher R. Kinsinger, Emily S. Boja, Gilbert S. Omenn, Arul M. Chinnaiyan, Henry Rodriguez, Qing Kay Li, Scott D. Jewell, Mathangi Thiagarajan, Gad Getz, Bing Zhang, David Fenyo, Kelly Ruggles, Marcin P. Cieslik, Ana Robles, Karl R. Clauser, Ramaswamy Govindan, Pei Wang, Alexey Nesvizhskii, Li Ding, D. R. Mani, Steven A. Carr
Article
Biochemical Research Methods
Anna Pamela Calinawan, Xiaoyu Song, Jiayi Ji, Saravana Mohan Dhanasekaran, Francesca Petralia, Pei Wang, Boris Reva
Article
Multidisciplinary Sciences
Noam D. Beckmann, Wei-Jye Lin, Minghui Wang, Ariella T. Cohain, Alexander W. Charney, Pei Wang, Weiping Ma, Ying-Chih Wang, Cheng Jiang, Mickael Audrain, Phillip H. Comella, Amanda K. Fakira, Siddharth P. Hariharan, Gillian M. Belbin, Kiran Girdhar, Allan Levey, Nicholas T. Seyfried, Eric B. Dammer, Duc Duong, James J. Lah, Jean-Vianney Haure-Mirande, Ben Shackleton, Tomas Fanutza, Robert Blitzer, Eimear Kenny, Jun Zhu, Vahram Haroutunian, Pavel Katsel, Sam Gandy, Zhidong Tu, Michelle E. Ehrlich, Bin Zhang, Stephen R. Salton, Eric E. Schadt
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Mi Yang, Francesca Petralia, Zhi Li, Hongyang Li, Weiping Ma, Xiaoyu Song, Sunkyu Kim, Heewon Lee, Han Yu, Bora Lee, Seohui Bae, Eunji Heo, Jan Kaczmarczyk, Piotr Stepniak, Michal Warchol, Thomas Yu, Anna P. Calinawan, Paul C. Boutros, Samuel H. Payne, Boris Reva, Emily Boja, Henry Rodriguez, Gustavo Stolovitzky, Yuanfang Guan, Jaewoo Kang, Pei Wang, David Fenyo, Julio Saez-Rodriguez
Article
Biochemistry & Molecular Biology
Francesca Petralia, Nicole Tignor, Boris Reva, Mateusz Koptyra, Shrabanti Chowdhury, Dmitry Rykunov, Azra Krek, Weiping Ma, Yuankun Zhu, Jiayi Ji, Anna Calinawan, Jeffrey R. Whiteaker, Antonio Colaprico, Vasileios Stathias, Tatiana Omelchenko, Xiaoyu Song, Pichai Raman, Yiran Guo, Miguel A. Brown, Richard G. Ivey, John Szpyt, Sanjukta Guha Thakurta, Marina A. Gritsenko, Karl K. Weitz, Gonzalo Lopez, Selim Kalayci, Zeynep H. Gumus, Seungyeul Yoo, Felipe Veiga Leprevost, Hui-Yin Chang, Karsten Krug, Lizabeth Katsnelson, Ying Wang, Jacob J. Kennedy, Uliana J. Voytovich, Lei Zhao, Krutika S. Gaonkar, Brian M. Ennis, Bo Zhang, Valerie Baubet, Lamiya Tauhid, Jena Lilly, Jennifer L. Mason, Bailey Farrow, Nathan Young, Sarah Leary, Jamie Moon, Vladislav A. Petyuk, Javad Nazarian, Nithin D. Adappa, James N. Palmer, Robert M. Lober, Samuel Rivero-Hinojosa, Liang-Bo Wang, Joshua M. Wang, Matilda Broberg, Rosalie K. Chu, Ronald J. Moore, Matthew E. Monroe, Rui Zhao, Richard D. Smith, Jun Zhu, Ana Robles, Mehdi Mesri, Emily Boja, Tara Hiltke, Henry Rodriguez, Bing Zhang, Eric E. Schadt, D. R. Mani, Li Ding, Antonio Iavarone, Maciej Wiznerowicz, Stephan Schurer, Xi S. Chen, Allison P. Heath, Jo Lynne Rokita, Alexey Nesvizhskii, David Fenyo, Karin D. Rodland, Tao Liu, Steven P. Gygi, Amanda G. Paulovich, Adam C. Resnick, Phillip B. Storm, Brian R. Rood, Pei Wang
Review
Cell Biology
Rafaela Fagundes, Leonardo K. Teixeira
Summary: DNA replication must be precisely controlled, and cell cycle transitions are regulated by the Cyclin-Dependent Kinases (CDKs) family. The Cyclin E/CDK2 complex controls cell cycle progression and DNA replication through phosphorylation of specific substrates in normal cycles, while its oncogenic activation causes replication stress and genomic instability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Statistics & Probability
Xiaoyu Song, Jiayi Ji, Pei Wang
Summary: This study proposes a statistical framework called iProMix to analyze the interaction between ACE2 protein and other proteins/pathways, and applies this framework in lung adenocarcinoma research to identify significant pathways associated with ACE2 protein abundances in epithelial cells.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Health Care Sciences & Services
Shilong Li, Zichen Wang, Luciana A. Vieira, Amanda B. Zheutlin, Boshu Ru, Emilio Schadt, Pei Wang, Alan B. Copperman, Joanne L. Stone, Susan J. Gross, Yu-Han Kao, Yan Kwan Lau, Siobhan M. Dolan, Eric E. Schadt, Li Li
Summary: By using machine learning and electronic medical records, we developed a model to predict the risk of preeclampsia with high accuracy across different pregnancy periods, and identified potential risk factors. This model is beneficial for early identification of high-risk patients and provides a pathway for personalized therapeutic strategies for those at risk.
NPJ DIGITAL MEDICINE
(2022)
Letter
Medicine, Research & Experimental
Shilong Li, Pei Wang, Li Li
Summary: The authors reply to a letter raising concerns about their interpretation of an interaction test in their paper. They clarify that their main clinical question was the association between ACE inhibitors and angiotensin receptor blockers and COVID-19 outcomes. They explain their use of stratification to control confounding factors and highlight that testing the interaction term assesses association heterogeneity, not treatment effectiveness.
JOURNAL OF CLINICAL INVESTIGATION
(2022)