标题
DNA replication stress: from molecular mechanisms to human disease
作者
关键词
DNA replication, Replicative stress, Replication fork, Replication origin, Checkpoint, DNA repair
出版物
CHROMOSOMA
Volume 126, Issue 1, Pages 1-15
出版商
Springer Nature
发表日期
2016-01-21
DOI
10.1007/s00412-016-0573-x
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Causes of genome instability: the effect of low dose chemical exposures in modern society
- (2015) Sabine A.S. Langie et al. CARCINOGENESIS
- SnapShot: Fanconi Anemia and Associated Proteins
- (2015) Anderson T. Wang et al. CELL
- Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle
- (2015) Sabela Búa et al. CELL CYCLE
- Cyclin E Deregulation Promotes Loss of Specific Genomic Regions
- (2015) Leonardo K. Teixeira et al. CURRENT BIOLOGY
- Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol
- (2015) María I. Martínez-Jiménez et al. DNA REPAIR
- Regulation of the Rev1-pol complex during bypass of a DNA interstrand cross-link
- (2015) M. Budzowska et al. EMBO JOURNAL
- IncreasedRrm2gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice
- (2015) Andres J. Lopez-Contreras et al. GENES & DEVELOPMENT
- DNA2 drives processing and restart of reversed replication forks in human cells
- (2015) Saravanabhavan Thangavel et al. JOURNAL OF CELL BIOLOGY
- Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
- (2015) Ralph Zellweger et al. JOURNAL OF CELL BIOLOGY
- ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress
- (2015) Yu-Hung Chen et al. MOLECULAR CELL
- Interaction of Chk1 with Treslin Negatively Regulates the Initiation of Chromosomal DNA Replication
- (2015) Cai Guo et al. MOLECULAR CELL
- Error-Free DNA Damage Tolerance and Sister Chromatid Proximity during DNA Replication Rely on the Polα/Primase/Ctf4 Complex
- (2015) Marco Fumasoni et al. MOLECULAR CELL
- Structure of the eukaryotic MCM complex at 3.8 Å
- (2015) Ningning Li et al. NATURE
- Crystal structure of the eukaryotic origin recognition complex
- (2015) Franziska Bleichert et al. NATURE
- Regulated eukaryotic DNA replication origin firing with purified proteins
- (2015) Joseph T. P. Yeeles et al. NATURE
- Exploiting replicative stress to treat cancer
- (2015) Matthias Dobbelstein et al. NATURE REVIEWS DRUG DISCOVERY
- Replication fork reversal in eukaryotes: from dead end to dynamic response
- (2015) Kai J. Neelsen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links
- (2015) M. Raschle et al. SCIENCE
- Variation in cancer risk among tissues can be explained by the number of stem cell divisions
- (2015) C. Tomasetti et al. SCIENCE
- Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality
- (2015) Silvia Alvarez et al. Nature Communications
- FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51
- (2015) Wai Kit Chu et al. Nature Communications
- Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia
- (2015) Kimberly A. Rickman et al. Cell Reports
- FBH1 Catalyzes Regression of Stalled Replication Forks
- (2015) Kasper Fugger et al. Cell Reports
- Human RecQ Helicases in DNA Repair, Recombination, and Replication
- (2014) Deborah L. Croteau et al. Annual Review of Biochemistry
- RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress
- (2014) Marco Saponaro et al. CELL
- Fos-dependent induction of Chk1 protects osteoblasts from replication stress
- (2014) Jochen Schulze et al. CELL CYCLE
- DNA Replication and Oncogene-Induced Replicative Stress
- (2014) Stephanie A. Hills et al. CURRENT BIOLOGY
- The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability
- (2014) Stephan Hamperl et al. DNA REPAIR
- Replication stress and cancer: It takes two to tango
- (2014) Emilio Lecona et al. EXPERIMENTAL CELL RESEARCH
- The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts
- (2014) E. Herrera-Moyano et al. GENES & DEVELOPMENT
- Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability
- (2014) Julie Sollier et al. MOLECULAR CELL
- XPF-ERCC1 Acts in Unhooking DNA Interstrand Crosslinks in Cooperation with FANCD2 and FANCP/SLX4
- (2014) Daisy Klein Douwel et al. MOLECULAR CELL
- Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
- (2014) Johanna Flach et al. NATURE
- BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
- (2014) Vaibhav Bhatia et al. NATURE
- Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
- (2014) Constance Alabert et al. NATURE CELL BIOLOGY
- Understanding nucleotide excision repair and its roles in cancer and ageing
- (2014) Jurgen A. Marteijn et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Visualization of recombination-mediated damage bypass by template switching
- (2014) Michele Giannattasio et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins
- (2014) Thomas A. Guilliam et al. NUCLEIC ACIDS RESEARCH
- Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies
- (2014) Y Aye et al. ONCOGENE
- Transcription and Recombination: When RNA Meets DNA
- (2014) A. Aguilera et al. Cold Spring Harbor Perspectives in Biology
- The Dissolution of Double Holliday Junctions
- (2014) A. H. Bizard et al. Cold Spring Harbor Perspectives in Biology
- Break-Induced Replication Is a Source of Mutation Clusters Underlying Kataegis
- (2014) Cynthia J. Sakofsky et al. Cell Reports
- Break-Induced Replication Requires DNA Damage-Induced Phosphorylation of Pif1 and Leads to Telomere Lengthening
- (2014) Yulia Vasianovich et al. PLoS Genetics
- Identification of Early Replicating Fragile Sites that Contribute to Genome Instability
- (2013) Jacqueline H. Barlow et al. CELL
- ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
- (2013) Luis Ignacio Toledo et al. CELL
- The balancing act of DNA repeat expansions
- (2013) Jane C Kim et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Co-ordination of base excision repair and genome stability
- (2013) Jason L. Parsons et al. DNA REPAIR
- hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity
- (2013) Li Wan et al. EMBO REPORTS
- ATR phosphorylates SMARCAL1 to prevent replication fork collapse
- (2013) F. B. Couch et al. GENES & DEVELOPMENT
- Identification of Proteins at Active, Stalled, and Collapsed Replication Forks Using Isolation of Proteins on Nascent DNA (iPOND) Coupled with Mass Spectrometry
- (2013) Bianca M. Sirbu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FBH1 Helicase Disrupts RAD51 Filamentsin Vitroand Modulates Homologous Recombination in Mammalian Cells
- (2013) Jitka Simandlova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication
- (2013) Julie Bianchi et al. MOLECULAR CELL
- PrimPol, an Archaic Primase/Polymerase Operating in Human Cells
- (2013) Sara García-Gómez et al. MOLECULAR CELL
- Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration
- (2013) Marenda A. Wilson et al. NATURE
- Migrating bubble during break-induced replication drives conservative DNA synthesis
- (2013) Natalie Saini et al. NATURE
- Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
- (2013) Molly C. Kottemann et al. NATURE
- Causes and consequences of replication stress
- (2013) Michelle K. Zeman et al. NATURE CELL BIOLOGY
- Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
- (2013) Matteo Berti et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Repriming of DNA synthesis at stalled replication forks by human PrimPol
- (2013) Silvana Mourón et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Break-induced replication occurs by conservative DNA synthesis
- (2013) R. A. Donnianni et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
- (2013) Lorenzo Costantino et al. SCIENCE
- Break-Induced DNA Replication
- (2013) R. P. Anand et al. Cold Spring Harbor Perspectives in Biology
- A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules
- (2013) Andres J. Lopez-Contreras et al. Cell Reports
- Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes
- (2013) Benoît Le Tallec et al. Cell Reports
- A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2
- (2012) Katharina Schlacher et al. CANCER CELL
- The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing
- (2012) Jiazhi Hu et al. CELL
- Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes
- (2012) Amaya Alzu et al. CELL
- Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells
- (2012) Raphael Ceccaldi et al. Cell Stem Cell
- Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis
- (2012) Tomás Aparicio et al. CHROMOSOMA
- Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype
- (2012) Marta B Davidson et al. EMBO JOURNAL
- dNTP pools determine fork progression and origin usage under replication stress
- (2012) Jérôme Poli et al. EMBO JOURNAL
- R-loops cause replication impairment and genome instability during meiosis
- (2012) Maikel Castellano-Pozo et al. EMBO REPORTS
- R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants
- (2012) P. C. Stirling et al. GENES & DEVELOPMENT
- Competition, collaboration and coordination - determining how cells bypass DNA damage
- (2012) J. E. Sale JOURNAL OF CELL SCIENCE
- An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
- (2012) Andres J. López-Contreras et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases
- (2012) Giacomo De Piccoli et al. MOLECULAR CELL
- Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress
- (2012) Alberto Ciccia et al. MOLECULAR CELL
- Coordinated control of replication and transcription by a SAPK protects genomic integrity
- (2012) Alba Duch et al. NATURE
- Y-family DNA polymerases and their role in tolerance of cellular DNA damage
- (2012) Julian E. Sale et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
- (2012) R M Jones et al. ONCOGENE
- A Dominantly Acting Murine Allele of Mcm4 Causes Chromosomal Abnormalities and Promotes Tumorigenesis
- (2012) Bruce N. Bagley et al. PLoS Genetics
- Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
- (2011) Katharina Schlacher et al. CELL
- DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase
- (2011) Katrin Paeschke et al. CELL
- The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores
- (2011) Rodrigo Bermejo et al. CELL
- Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements
- (2011) Pengfei Liu et al. CELL
- Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
- (2011) Assaf C. Bester et al. CELL
- Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles
- (2011) Belén Gómez-González et al. EMBO JOURNAL
- Genome-wide depletion of replication initiation events in highly transcribed regions
- (2011) M. M. Martin et al. GENOME RESEARCH
- The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers
- (2011) Anne Blumrich et al. HUMAN MOLECULAR GENETICS
- Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes
- (2011) Anne Helmrich et al. MOLECULAR CELL
- RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability
- (2011) Lamia Wahba et al. MOLECULAR CELL
- Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression
- (2011) Tsuyoshi Kawabata et al. MOLECULAR CELL
- Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites
- (2011) Efrat Ozeri-Galai et al. MOLECULAR CELL
- Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
- (2011) Anne Letessier et al. NATURE
- Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome
- (2011) Duane L Guernsey et al. NATURE GENETICS
- Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome
- (2011) Louise S Bicknell et al. NATURE GENETICS
- Mutations in the pre-replication complex cause Meier-Gorlin syndrome
- (2011) Louise S Bicknell et al. NATURE GENETICS
- Molecular profiling of common fragile sites in human fibroblasts
- (2011) Benoî Le Tallec et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
- (2011) Matilde Murga et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- UV stalled replication forks restart by re-priming in human fibroblasts
- (2011) Ingegerd Elvers et al. NUCLEIC ACIDS RESEARCH
- Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair
- (2011) D. T. Long et al. SCIENCE
- Break-Induced Replication Is Highly Inaccurate
- (2011) Angela Deem et al. PLOS BIOLOGY
- Eukaryotic Chromosome DNA Replication: Where, When, and How?
- (2010) Hisao Masai et al. Annual Review of Biochemistry
- Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562 – Molecular characterization of FRA2H and localization of a new CFS FRA2S
- (2010) Franca Pelliccia et al. CANCER LETTERS
- The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase
- (2010) Georgios I. Karras et al. CELL
- The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest
- (2010) Julia M. Sidorova et al. CELL CYCLE
- Cohesin organizes chromatin loops at DNA replication factories
- (2010) E. Guillou et al. GENES & DEVELOPMENT
- Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly
- (2010) J. R. Lydeard et al. GENES & DEVELOPMENT
- Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories
- (2010) Xin Quan Ge et al. JOURNAL OF CELL BIOLOGY
- Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
- (2010) Eva Petermann et al. MOLECULAR CELL
- The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response
- (2010) Min Huang et al. MOLECULAR CELL
- Ubiquitin-dependent DNA damage bypass is separable from genome replication
- (2010) Yasukazu Daigaku et al. NATURE
- Damage-induced phosphorylation of Sld3 is important to block late origin firing
- (2010) Jaime Lopez-Mosqueda et al. NATURE
- Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation
- (2010) Philip Zegerman et al. NATURE
- Pathways of mammalian replication fork restart
- (2010) Eva Petermann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
- (2010) Yoshitami Hashimoto et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanisms and implications of transcription blockage by guanine-rich DNA sequences
- (2010) B. P. Belotserkovskii et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Replication and Recombination Factors Contributing to Recombination-Dependent Bypass of DNA Lesions by Template Switch
- (2010) Fabio Vanoli et al. PLoS Genetics
- Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder
- (2009) Regina Waltes et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription
- (2009) Rodrigo Bermejo et al. CELL
- Tipin/Tim1/And1 protein complex promotes Polα chromatin binding and sister chromatid cohesion
- (2009) Alessia Errico et al. EMBO JOURNAL
- A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome
- (2009) Agnieszka Gambus et al. EMBO JOURNAL
- Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
- (2009) Sigal Shachar et al. EMBO JOURNAL
- Intrauterine programming of ageing
- (2009) Oscar Fernandez-Capetillo EMBO REPORTS
- The annealing helicase HARP protects stalled replication forks
- (2009) J. Yuan et al. GENES & DEVELOPMENT
- The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks
- (2009) C. E. Bansbach et al. GENES & DEVELOPMENT
- FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange
- (2009) Joshua A. Sommers et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
- (2009) Sandie Tuduri et al. NATURE CELL BIOLOGY
- Molecular Basis of Colorectal Cancer
- (2009) Sanford D. Markowitz et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNA Damage, Aging, and Cancer
- (2009) Jan H.J. Hoeijmakers NEW ENGLAND JOURNAL OF MEDICINE
- The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair
- (2009) Ivan V. Rosado et al. NUCLEIC ACIDS RESEARCH
- The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
- (2009) P. Knipscheer et al. SCIENCE
- Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24
- (2008) J. M. Kim et al. BLOOD
- Stems Cells and the Pathways to Aging and Cancer
- (2008) Derrick J. Rossi et al. CELL
- Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair
- (2008) Markus Räschle et al. CELL
- The role of the DNA damage response pathways in brain development and microcephaly: Insight from human disorders
- (2008) Mark O’Driscoll et al. DNA REPAIR
- Replication fork arrest, recombination and the maintenance of ribosomal DNA stability
- (2008) E TSANG et al. DNA REPAIR
- The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
- (2008) Sharon Biton et al. DNA REPAIR
- Plx1 is required for chromosomal DNA replication under stressful conditions
- (2008) Kristina Trenz et al. EMBO JOURNAL
- Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response
- (2008) Isabelle Morin et al. EMBO JOURNAL
- Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks
- (2008) M. Segurado et al. GENES & DEVELOPMENT
- RECQ1 Possesses DNA Branch Migration Activity
- (2008) Dmitry V. Bugreev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40
- (2008) Charlotte E. Edmunds et al. MOLECULAR CELL
- SUMOylation regulates Rad18-mediated template switch
- (2008) Dana Branzei et al. NATURE
- ATR: an essential regulator of genome integrity
- (2008) Karlene A. Cimprich et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
- (2008) Arkaitz Ibarra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Oncogene-Induced DNA Damage Model for Cancer Development
- (2008) T. D. Halazonetis et al. SCIENCE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started