Therapeutic implications of altered cholesterol homeostasis mediated by loss of CYP46A1 in human glioblastoma

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

(2019) Ying Jiang et al.   NATURE

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice

(2019) Alexey M. Petrov et al.   Neurotherapeutics

Dual IRE1 RNase functions dictate glioblastoma development

(2018) Stéphanie Lhomond et al.   EMBO Molecular Medicine

Six-Transmembrane Epithelial Antigen of Prostate 3 Predicts Poor Prognosis and Promotes Glioblastoma Growth and Invasion

(2018) Mingzhi Han et al.   NEOPLASIA

The Effects of Cholesterol-Derived Oncometabolites on Nuclear Receptor Function in Cancer

(2018) Sandrine Silvente-Poirot et al.   CANCER RESEARCH

Epigenetic Targeting of Glioblastoma

(2018) Massimo Romani et al.   Frontiers in Oncology

Efavirenz: What is known about the cellular mechanisms responsible for its adverse effects

(2017) Nadezda Apostolova et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vitrocytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

(2017) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

(2017) Natalia Mast et al.   NEUROPHARMACOLOGY

Different Cell Cycle Modulation in SKOV-3 Ovarian Cancer Cell Line by Anti-HIV Drugs

(2017) Angelica Perna et al.   ONCOLOGY RESEARCH

The Role of Oxysterols in Human Cancer

(2017) Alzbeta Kloudova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

Chromatin-Modifying Agents Increase Transcription of CYP46A1, a Key Player in Brain Cholesterol Elimination

(2017) Inês Milagre et al.   JOURNAL OF ALZHEIMERS DISEASE

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond

(2016) Miguel Moutinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol: An Achilles’ Heel for Glioblastoma?

(2016) Zhenyi An et al.   CANCER CELL

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

(2016) Genaro R. Villa et al.   CANCER CELL

The Role of Cholesterol in Cancer

(2016) Omer F. Kuzu et al.   CANCER RESEARCH

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

(2016) F. Geng et al.   CLINICAL CANCER RESEARCH

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity

(2016) Kyle W. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development

(2016) Matias Soncini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer

(2016) Rebecca Swan et al.   Oncotarget

Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer

(2015) Fabiola Bovenga et al.   Cell Metabolism

New aspects of 24( S )-hydroxycholesterol in modulating neuronal cell death

(2015) Noriko Noguchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cerebrospinal Fluid Inhibitory Quotients of Antiretroviral Drugs in HIV-Infected Patients Are Associated With Compartmental Viral Control

(2014) Andrea Calcagno et al.   CLINICAL INFECTIOUS DISEASES

Cerebrospinal Fluid Exposure of Efavirenz and Its Major Metabolites When Dosed at 400 mg and 600 mg Once Daily: A Randomized Controlled Trial

(2014) Alan Winston et al.   CLINICAL INFECTIOUS DISEASES

A Phase II Trial Evaluating the Efficacy and Safety of Efavirenz in Metastatic Castration-Resistant Prostate Cancer

(2014) N. Houede et al.   ONCOLOGIST

Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression

(2013) Valerio Leoni et al.   NEUROBIOLOGY OF DISEASE

Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease

(2013) Ingemar Björkhem et al.   NEUROSCIENCE LETTERS

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

(2013) Qian Wu et al.   Cell Reports

Efavirenz Pharmacokinetics in Cerebrospinal Fluid and Plasma over a 24-Hour Dosing Interval

(2012) Aylin Yilmaz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis

(2012) Jing Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Efavirenz concentrations in CSF exceed IC50 for wild-type HIV

(2010) B. M. Best et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression ofCYP46A1gene transcription

(2010) Maria João Nunes et al.   JOURNAL OF NEUROCHEMISTRY

Identification of 5 ,6 -Epoxycholesterol as a Novel Modulator of Liver X Receptor Activity

(2010) T. J. Berrodin et al.   MOLECULAR PHARMACOLOGY

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Reverse transcriptase inhibitors induce cell differentiation and enhance the immunogenic phenotype in human renal clear-cell carcinoma

(2008) Matteo Landriscina et al.   INTERNATIONAL JOURNAL OF CANCER

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA