Dendrogenin A drives LXR to trigger lethal autophagy in cancers

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

When cholesterol meets histamine, it gives rise to dendrogenin A: a tumour suppressor metabolite 1

(2016) Marc Poirot et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

From tamoxifen to dendrogenin A: The discovery of a mammalian tumor suppressor and cholesterol metabolite

(2016) Sandrine Silvente-Poirot et al.   BIOCHIMIE

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

Ipilimumab Combined with Nivolumab: A Standard of Care for the Treatment of Advanced Melanoma?

(2016) Matteo S. Carlino et al.   CLINICAL CANCER RESEARCH

The discovery of vemurafenib for the treatment of BRAF-mutated metastatic melanoma

(2016) Alex Kim et al.   Expert Opinion on Drug Discovery

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Monoubiquitination of Histone H2B Blocks Eviction of Histone Variant H2A.Z from Inducible Enhancers

(2016) Gregory Segala et al.   MOLECULAR CELL

AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

(2016) Hi-Jai R. Shin et al.   NATURE

Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice

(2016) Yu-bing Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation

(2016) Daniel Savic et al.   Genome Medicine

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

(2015) Colin A. Flaveny et al.   CANCER CELL

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

(2015) Ksenya Shchors et al.   CANCER CELL

Dendrogenin A: A Mammalian Metabolite of Cholesterol with Tumor Suppressor and Neurostimulating Properties

(2015) Florence Dalenc et al.   CURRENT MEDICINAL CHEMISTRY

The emerging roles of liver X receptors and their ligands in cancer

(2015) Chin-Yo Lin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Subset of Nuclear Receptors are Uniquely Expressed in Uveal Melanoma Cells

(2015) Kenneth Edward Huffman et al.   Frontiers in Endocrinology

Antiestrogen-binding site ligands induce autophagy in myeloma cells that proceeds through alteration of cholesterol metabolism

(2015) Brigitte Sola et al.   Oncotarget

A method to measure cardiac autophagic flux in vivo

(2014) Eri Iwai-Kanai et al.   Autophagy

When cytoprotective autophagy isn’t… and even when it is

(2014) David A Gewirtz   Autophagy

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Broad-Spectrum Therapeutic Suppression of Metastatic Melanoma through Nuclear Hormone Receptor Activation

(2014) Nora Pencheva et al.   CELL

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cholesterol and Cancer, in the Balance

(2014) S. Silvente-Poirot et al.   SCIENCE

5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells

(2013) Gregory Segala et al.   BIOCHEMICAL PHARMACOLOGY

Target analysis by integration of transcriptome and ChIP-seq data with BETA

(2013) Su Wang et al.   Nature Protocols

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties

(2013) Philippe de Medina et al.   Nature Communications

MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy

(2012) Salome Paillas et al.   Autophagy

Exploiting the Mutanome for Tumor Vaccination

(2012) J. C. Castle et al.   CANCER RESEARCH

Cholesterol metabolism and resistance to tamoxifen

(2012) Marc Poirot et al.   CURRENT OPINION IN PHARMACOLOGY

Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles

(2012) Michael R. Paillasse et al.   JOURNAL OF LIPID RESEARCH

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities

(2012) Tomas Jakobsson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Selective liver X receptor modulators (SLiMs): What use in human health?

(2011) Emilie Viennois et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Identification of Patients With Acute Myeloblastic Leukemia Who Benefit From the Addition of Gemtuzumab Ozogamicin: Results of the MRC AML15 Trial

(2010) Alan K. Burnett et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression Profiling of Nuclear Receptors in the NCI60 Cancer Cell Panel Reveals Receptor-Drug and Receptor-Gene Interactions

(2010) Susan Holbeck et al.   MOLECULAR ENDOCRINOLOGY

Auraptene Is an Inhibitor of Cholesterol Esterification and a Modulator of Estrogen Receptors

(2010) P. de Medina et al.   MOLECULAR PHARMACOLOGY

Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells

(2010) A J C Pommier et al.   ONCOGENE

Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands

(2010) P. de Medina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation

(2009) Philippe de Medina et al.   Autophagy

Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism

(2009) P de Medina et al.   CELL DEATH AND DIFFERENTIATION

Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes

(2009) N Kumar et al.   INTERNATIONAL JOURNAL OF OBESITY

Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases

(2009) Philippe de Medina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism

(2008) B. Payre et al.   MOLECULAR CANCER THERAPEUTICS