Targeting MmpL3 for anti-tuberculosis drug development

Repurposed drug candidates for antituberculosis therapy

(2020) Qi An et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Photoactivatable Glycolipid Probes for Identifying Mycolate–Protein Interactions in Live Mycobacteria

(2020) Herbert W. Kavunja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO

(2020) Xiaolin Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct Inhibition of MmpL3 by Novel Antitubercular Compounds

(2019) Wei Li et al.   ACS Infectious Diseases

Mass spectrometry: From plasma proteins to mitochondrial membranes

(2019) Carol V. Robinson   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target

(2019) Bing Zhang et al.   CELL

Membrane Protein–Lipid Interactions Probed Using Mass Spectrometry

(2019) Jani Reddy Bolla et al.   Annual Review of Biochemistry

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

(2019) Chih-Chia Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria

(2019) Allison Fay et al.   mBio

The MmpL3 interactome reveals a complex crosstalk between cell envelope biosynthesis and cell elongation and division in mycobacteria

(2019) Juan Manuel Belardinelli et al.   Scientific Reports

Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance

(2019) John T. Williams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transport mechanism of Mycobacterium tuberculosis MmpL/S family proteins and implications in pharmaceutical targeting

(2019) Shuang Ma et al.   BIOLOGICAL CHEMISTRY

Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis

(2019) Geoff C. Melly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The crystal structure of the mycobacterial trehalose monomycolate transport factor A, TtfA, reveals an atypical fold

(2019) Kien Lam Ung et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter

(2018) Huiqing Zheng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption

(2018) Annanya Shetty et al.   Frontiers in Microbiology

Crystal structures of theBurkholderia multivoranshopanoid transporter HpnN

(2017) Nitin Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MmpL3 is the flippase for mycolic acids in mycobacteria

(2017) Zhujun Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberculosis — drugs in the 2016 development pipeline

(2017) Barbara E. Laughon et al.   Nature Reviews Disease Primers

Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling

(2017) Emmanuel C. Patin et al.   PLoS One

Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression

(2017) Giulia Degiacomi et al.   Scientific Reports

Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane

(2017) Laura Chiaradia et al.   Scientific Reports

A sliding selectivity scale for lipid binding to membrane proteins

(2016) Michael Landreh et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

MmpL3 Inhibitors: Diverse Chemical Scaffolds Inhibit the Same Target

(2016) Giovanna Poce et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A new piperidinol derivative targeting mycolic acid transport inMycobacterium abscessus

(2016) Christian Dupont et al.   MOLECULAR MICROBIOLOGY

MmpL transporter-mediated export of cell-wall associated lipids and siderophores in mycobacteria

(2016) Christian Chalut   TUBERCULOSIS

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis

(2016) Marie H. Foss et al.   ACS Infectious Diseases

Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis

(2016) Juan Manuel Belardinelli et al.   ACS Infectious Diseases

Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development

(2015) Rebeca Bailo et al.   BIOCHEMICAL PHARMACOLOGY

Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members

(2015) Audrey Bernut et al.   MOLECULAR MICROBIOLOGY

Heavy metal transport by the CusCFBA efflux system

(2015) Jared A. Delmar et al.   PROTEIN SCIENCE

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis

(2014) R. C. Hartkoorn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

(2014) Wei Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ThreeMycobacterium tuberculosisAntigen 85 Isoforms Have Unique Substrates and Activities Determined by Non-active Site Regions

(2014) Keriann M. Backus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

(2014) Kai Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

How sisters grow apart: mycobacterial growth and division

(2014) Karen J. Kieser et al.   NATURE REVIEWS MICROBIOLOGY

Multi-drug-resistant tuberculosis in HIV positive patients in Eastern Europe

(2013) Frank A. Post et al.   JOURNAL OF INFECTION

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

(2013) Modesto J. Remuiñán et al.   PLoS One

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

(2013) S. P. S. Rao et al.   Science Translational Medicine

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

(2013) Shichun Lun et al.   Nature Communications

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria

(2012) Cristian Varela et al.   CHEMISTRY & BIOLOGY

Nonprotein Structures from Mycobacteria: Emerging Actors for Tuberculosis Control

(2012) Luz M. Lopez-Marin   Clinical & Developmental Immunology

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

(2012) Katherine A Sacksteder et al.   Future Microbiology

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

(2012) Anna E Grzegorzewicz et al.   Nature Chemical Biology

Advances in the Mass Spectrometry of Membrane Proteins: From Individual Proteins to Intact Complexes

(2011) Nelson P. Barrera et al.   Annual Review of Biochemistry

MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

(2011) Valentina La Rosa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex

(2011) Liliana Rodrigues et al.   INFECTION GENETICS AND EVOLUTION

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

(2010) Neel R Gandhi et al.   LANCET