Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis

Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases

(2014) Kai Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties

(2013) E. Jeffrey North et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Progress in targeting cell envelope biogenesis inMycobacterium tuberculosis

(2013) Mary Jackson et al.   Future Microbiology

Preliminary Structure–Activity Relationships and Biological Evaluation of Novel Antitubercular Indolecarboxamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

(2013) Oluseye K. Onajole et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents

(2013) Ravinder Reddy Kondreddi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug-resistant tuberculosis: time for visionary political leadership

(2013) Ibrahim Abubakar et al.   LANCET INFECTIOUS DISEASES

Improved BM212 MmpL3 Inhibitor Analogue Shows Efficacy in Acute Murine Model of Tuberculosis Infection

(2013) Giovanna Poce et al.   PLoS One

Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3

(2013) Modesto J. Remuiñán et al.   PLoS One

Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis

(2013) Thomas R. Ioerger et al.   PLoS One

Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis

(2013) S. P. S. Rao et al.   Science Translational Medicine

Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?

(2013) Robert C. Goldman   TUBERCULOSIS

Indoleamides are active against drug-resistant Mycobacterium tuberculosis

(2013) Shichun Lun et al.   Nature Communications

Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis

(2013) Ryan M. Wells et al.   PLoS Pathogens

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

(2012) Kapil Tahlan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

(2012) Katherine A Sacksteder et al.   Future Microbiology

Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane

(2012) Anna E Grzegorzewicz et al.   Nature Chemical Biology

Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels

(2011) Ping Lu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

(2011) Valentina La Rosa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tuberculosis drugs: new candidates and how to find more

(2011) Claudia Sala et al.   Future Microbiology

Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis

(2010) C. Sala et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase

(2010) Takahiro Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

PapA3 Is an Acyltransferase Required for Polyacyltrehalose Biosynthesis inMycobacterium tuberculosis

(2009) Stavroula K. Hatzios et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence

(2009) Rakesh K. Dhiman et al.   MOLECULAR MICROBIOLOGY

Multidrug efflux transporter, AcrB—the pumping mechanism

(2008) S MURAKAMI   CURRENT OPINION IN STRUCTURAL BIOLOGY

Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug

(2004) Lee Jia et al.   BRITISH JOURNAL OF PHARMACOLOGY