Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance
Authors
Keywords
-
Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 63, Issue 10, Pages -
Publisher
American Society for Microbiology
Online
2019-08-07
DOI
10.1128/aac.00547-19
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Direct Inhibition of MmpL3 by Novel Antitubercular Compounds
- (2019) Wei Li et al. ACS Infectious Diseases
- Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target
- (2019) Bing Zhang et al. CELL
- MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine
- (2019) Chih-Chia Su et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter
- (2018) Huiqing Zheng et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Therapeutic potential of promiscuous targets in Mycobacterium tuberculosis
- (2018) Bei Shi Lee et al. CURRENT OPINION IN PHARMACOLOGY
- Genetic and metabolic regulation of Mycobacterium tuberculosis acid growth arrest
- (2018) Jacob J. Baker et al. Scientific Reports
- MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections
- (2018) Wei Li et al. Frontiers in Microbiology
- Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption
- (2018) Annanya Shetty et al. Frontiers in Microbiology
- Suppressive drug combinations and their potential to combat antibiotic resistance
- (2017) Nina Singh et al. JOURNAL OF ANTIBIOTICS
- Mutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis
- (2017) Matthew B. McNeil et al. MICROBIOLOGY-SGM
- MmpL3 is the flippase for mycolic acids in mycobacteria
- (2017) Zhujun Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Efficient measurement and factorization of high-order drug interactions in Mycobacterium tuberculosis
- (2017) Murat Cokol et al. Science Advances
- Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression
- (2017) Giulia Degiacomi et al. Scientific Reports
- Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3
- (2016) Wei Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Inhibition of Leishmania mexicana Growth by the Tuberculosis Drug SQ109
- (2016) Verónica García-García et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Repurposing of a drug scaffold: Identification of novel sila analogues of rimonabant as potent antitubercular agents
- (2016) Remya Ramesh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- MmpL3 Inhibitors: Diverse Chemical Scaffolds Inhibit the Same Target
- (2016) Giovanna Poce et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- A new piperidinol derivative targeting mycolic acid transport inMycobacterium abscessus
- (2016) Christian Dupont et al. MOLECULAR MICROBIOLOGY
- Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence
- (2016) Huiqing Zheng et al. Nature Chemical Biology
- Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis
- (2016) Marie H. Foss et al. ACS Infectious Diseases
- Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis
- (2016) Juan Manuel Belardinelli et al. ACS Infectious Diseases
- THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria
- (2016) Jonathan A. G. Cox et al. Nature Microbiology
- The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence
- (2015) Benjamin K. Johnson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis
- (2015) Nicholas Chim et al. CHEMISTRY & BIOLOGY
- Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution
- (2015) Tobias Bollenbach CURRENT OPINION IN MICROBIOLOGY
- I-TASSER server: new development for protein structure and function predictions
- (2015) Jianyi Yang et al. NUCLEIC ACIDS RESEARCH
- Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae
- (2014) Yoshiki Yamaryo-Botte et al. ACS Chemical Biology
- Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis
- (2014) Wei Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis
- (2013) Lluís Ballell et al. ChemMedChem
- Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3
- (2013) Modesto J. Remuiñán et al. PLoS One
- Identification of New Drug Targets and Resistance Mechanisms in Mycobacterium tuberculosis
- (2013) Thomas R. Ioerger et al. PLoS One
- Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis
- (2013) S. P. S. Rao et al. Science Translational Medicine
- Indoleamides are active against drug-resistant Mycobacterium tuberculosis
- (2013) Shichun Lun et al. Nature Communications
- Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening
- (2012) Sarah A. Stanley et al. ACS Chemical Biology
- SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
- (2012) Kapil Tahlan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria
- (2012) Cristian Varela et al. CHEMISTRY & BIOLOGY
- Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action
- (2012) Katherine A Sacksteder et al. Future Microbiology
- The Why and How of Z Scores
- (2012) Steven D. Colan JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
- Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
- (2012) Anna E Grzegorzewicz et al. Nature Chemical Biology
- MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212
- (2011) Valentina La Rosa et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism
- (2011) Jennifer E. Griffin et al. PLoS Pathogens
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
- (2010) A. McKenna et al. GENOME RESEARCH
- Optimisation of Bioluminescent Reporters for Use with Mycobacteria
- (2010) Nuria Andreu et al. PLoS One
- The MycoBrowser portal: A comprehensive and manually annotated resource for mycobacterial genomes
- (2010) Adamandia Kapopoulou et al. TUBERCULOSIS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started