Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

(2020) Aiping Wu et al.   Cell Host & Microbe

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer

(2020) Sufang Tian et al.   Journal of Thoracic Oncology

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

COVID-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome

(2020) Luciano Gattinoni et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

COVID-19 and its implications for thrombosis and anticoagulation

(2020) Jean Marie Connors et al.   BLOOD

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence

(2020) Julien Poissy et al.   CIRCULATION

Will Complement Inhibition Be the New Target in Treating COVID-19–Related Systemic Thrombosis?

(2020) Courtney M. Campbell et al.   CIRCULATION

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

(2020) Soeren Lukassen et al.   EMBO JOURNAL

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

(2020) Julie Helms et al.   INTENSIVE CARE MEDICINE

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis

(2020) Jieyun Zhu et al.   JOURNAL OF MEDICAL VIROLOGY

Tocilizumab for the treatment of severe coronavirus disease 2019

(2020) Rand Alattar et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up

(2020) Behnood Bikdeli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series

(2020) Janice Wang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombocytopenia and its association with mortality in patients with COVID‐19

(2020) Xiaobo Yang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hypercoagulability of COVID‐19 patients in Intensive Care Unit. A Report of Thromboelastography Findings and other Parameters of Hemostasis

(2020) Mauro Panigada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

D‐dimer levels on admission to predict in‐hospital mortality in patients with Covid‐19

(2020) Litao Zhang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Uncertainties on the prognostic value of D‐dimers in COVID‐19 patients

(2020) Jean‐Christophe Gris et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients

(2020) Jean‐François Llitjos et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Incidence of venous thromboembolism in hospitalized patients with COVID‐19

(2020) Saskia Middeldorp et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia

(2020) Songping Cui et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

(2020) Claire S Whyte et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The procoagulant pattern of patients with COVID‐19 acute respiratory distress syndrome

(2020) Marco Ranucci et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

COVID-19 update: Covid-19-associated coagulopathy

(2020) Richard C. Becker   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulmonary Embolism or Pulmonary Thrombosis in COVID-19? Is the Recommendation to Use High-Dose Heparin for Thromboprophylaxis Justified?

(2020) Marco Cattaneo et al.   THROMBOSIS AND HAEMOSTASIS

Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research

(2020) Mahesh V. Madhavan et al.   THROMBOSIS AND HAEMOSTASIS

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

(2020) Tao Chen et al.   BMJ-British Medical Journal

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

(2020) Frank L van de Veerdonk et al.   eLife

Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans

(2020) Sharon E Fox et al.   Lancet Respiratory Medicine

Comparison of Venous Thromboembolism Risks Between COVID-19 Pneumonia and Community-Acquired Pneumonia Patients

(2020) Fei Mei et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Overcoming Barriers

(2020) Dakota Gustafson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection

(2020) Hanny Al-Samkari et al.   BLOOD

Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past

(2020) Dimitrios Giannis et al.   JOURNAL OF CLINICAL VIROLOGY

Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels

(2020) P. Demelo-Rodríguez et al.   THROMBOSIS RESEARCH

Coagulation abnormalities and thrombosis in patients with COVID-19

(2020) Marcel Levi et al.   Lancet Haematology

Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality

(2019) Upasana Kulkarni et al.   Mucosal Immunology

The role of platelets in mediating a response to human influenza infection

(2019) Milka Koupenova et al.   Nature Communications

Neutrophil Extracellular Traps

(2019) Charlotte Thålin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Diagnosis and management of sepsis‐induced coagulopathy and disseminated intravascular coagulation

(2019) Toshiaki Iba et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical promise of next-generation complement therapeutics

(2019) Dimitrios C. Mastellos et al.   NATURE REVIEWS DRUG DISCOVERY

The Middle East Respiratory Syndrome (MERS)

(2019) Esam I. Azhar et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Tissue Factor

(2018) Steven P. Grover et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

(2018) Milka Koupenova et al.   CIRCULATION RESEARCH

Acute Respiratory Distress Syndrome

(2018) Eddy Fan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection

(2018) Liuluan Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

(2018) Yuting Jiang et al.   Emerging Microbes & Infections

Cytokine release syndrome

(2018) Alexander Shimabukuro-Vornhagen et al.   Journal for ImmunoTherapy of Cancer

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients

(2018) Andrea T. Obi et al.   Journal of Vascular Surgery-Venous and Lymphatic Disorders

Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection

(2017) Emma E. Hornick et al.   JOURNAL OF IMMUNOLOGY

Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2

(2017) Lennart Michel Reinke et al.   PLoS One

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

Cytokine storms in infectious diseases

(2017) John R. Teijaro   Seminars in Immunopathology

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

New fronts emerge in the influenza cytokine storm

(2017) Xi-zhi J. Guo et al.   Seminars in Immunopathology

Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection

(2017) Teresa Peiró et al.   THORAX

Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species

(2017) Smanla Tundup et al.   PLoS Pathogens

A Role for Neutrophils in Viral Respiratory Disease

(2017) Jeremy V. Camp et al.   Frontiers in Immunology

Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection

(2016) Matthew T. Rondina et al.   CRITICAL CARE MEDICINE

Immunotherapeutic implications of IL-6 blockade for cytokine storm

(2016) Toshio Tanaka et al.   Immunotherapy

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice

(2016) S. Antoniak et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Middle East Respiratory Syndrome Virus Pathogenesis

(2016) Sunit Singh   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

(2015) Jenny Björkqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

Middle East Respiratory Syndrome Coronavirus Causes Multiple Organ Damage and Lethal Disease in Mice Transgenic for Human Dipeptidyl Peptidase 4

(2015) Kun Li et al.   JOURNAL OF INFECTIOUS DISEASES

Clinical characteristics of 75 pandemic H1N1 influenza patientsfrom Turkey; risk factors for fatality

(2015) Hatice KILIÇ et al.   Turkish Journal Of Medical Sciences

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

(2015) Allison L. Totura et al.   mBio

Multiple roles of the coagulation protease cascade during virus infection

(2014) S. Antoniak et al.   BLOOD

Hospital-Associated Outbreak of Middle East Respiratory Syndrome Coronavirus: A Serologic, Epidemiologic, and Clinical Description

(2014) Mohammad Mousa Al-Abdallat et al.   CLINICAL INFECTIOUS DISEASES

Pathogenesis of Middle East respiratory syndrome coronavirus

(2014) Judith MA van den Brand et al.   JOURNAL OF PATHOLOGY

A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection

(2013) Marlène Brandes et al.   CELL

Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

(2013) R. J. de Groot et al.   JOURNAL OF VIROLOGY

Is MERS another SARS?

(2013) Christian Drosten   LANCET INFECTIOUS DISEASES

The Association between Serum Biomarkers and Disease Outcome in Influenza A(H1N1)pdm09 Virus Infection: Results of Two International Observational Cohort Studies

(2013) Richard T. Davey et al.   PLoS One

Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

(2013) L. E. Gralinski et al.   mBio

Endothelial activation and dysfunction in the pathogenesis of influenza A virus infection

(2013) Susan M Armstrong et al.   Virulence

In Vivo Platelet Activation in Critically Ill Patients With Primary 2009 Influenza A(H1N1)

(2012) Matthew T. Rondina et al.   CHEST

Coinfection with Staphylococcus aureus increases risk of severe coagulopathy in critically ill children with influenza A (H1N1) virus infection

(2012) Trung Nguyen et al.   CRITICAL CARE MEDICINE

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Modulation of Coagulation and Fibrinolysis in Acute Lung Injury and the Acute Respiratory Distress Syndrome

(2011) Sara C. Sebag et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Serum D-dimer changes and prognostic implication in 2009 novel influenza A(H1N1)

(2011) Z.F. Wang et al.   THROMBOSIS RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Pandemic H1N1 Influenza Infection and Vascular Thrombosis

(2010) P. E. Bunce et al.   CLINICAL INFECTIOUS DISEASES

Thromboprophylaxis in the intensive care unit: Focus on medical–surgical patients

(2010) Deborah J. Cook et al.   CRITICAL CARE MEDICINE

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

(2009) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells

(2008) A. Shibamiya et al.   BLOOD

TLRs and innate immunity

(2008) B. A. Beutler   BLOOD