Shared mechanisms of multimorbidity in COPD, atherosclerosis and type-2 diabetes: the neutrophil as a potential inflammatory target

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium

(2020) Ingrid Gomez et al.   Nature Communications

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Protein Misfolding in Cardiac Disease

(2019) Christoph Hofmann et al.   CIRCULATION

Priming and de-priming of neutrophil responses in vitro and in vivo

(2018) Katja L. Vogt et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Inflammation and neutrophil immunosenescence in health and disease: Targeted treatments to improve clinical outcomes in the elderly

(2018) William Drew et al.   EXPERIMENTAL GERONTOLOGY

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Correlation of severity of chronic obstructive pulmonary disease with potential biomarkers

(2018) Seema Singh et al.   IMMUNOLOGY LETTERS

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells

(2018) HyunTae V. Hwang et al.   PLoS One

Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis

(2018) Che-Sheng Chu et al.   Scientific Reports

A System of Cytokines Encapsulated in ExtraCellular Vesicles

(2018) Wendy Fitzgerald et al.   Scientific Reports

Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease

(2018) Joseph Jacob et al.   EBioMedicine

Programming CAR-T cells to kill cancer

(2018) Louai Labanieh et al.   Nature Biomedical Engineering

Serum Matrix Metalloproteinase 9 and Macrophage Migration Inhibitory Factor (MIF) Are Increased in Young Healthy Nonobese Subjects with Positive Family History of Type 2 Diabetes

(2018) Agnieszka Nikołajuk et al.   International Journal of Endocrinology

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Cardiovascular outcomes with an inhaled beta2-agonist/corticosteroid in patients with COPD at high cardiovascular risk

(2017) Robert D Brook et al.   HEART

Cardiovascular event risk assessment in psoriasis patients treated with tumor necrosis factor-α inhibitors versus methotrexate

(2017) Jashin J. Wu et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Regulation of lung endothelial permeability and inflammatory responses by prostaglandin A2: role of EP4 receptor

(2017) Tomomi Ohmura et al.   MOLECULAR BIOLOGY OF THE CELL

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hyperglycemia Impairs Neutrophil Mobilization Leading to Enhanced Metastatic Seeding

(2017) Tanya Fainsod-Levi et al.   Cell Reports

Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease

(2017) Xiaoyan Min et al.   Biomed Research International

High prevalence of COPD in atherosclerosis patients

(2017) Izabela Tuleta et al.   International Journal of Chronic Obstructive Pulmonary Disease

Advanced Role of Neutrophils in Common Respiratory Diseases

(2017) Jinping Liu et al.   Journal of Immunology Research

Mechanical deformation induces depolarization of neutrophils

(2017) Andrew E. Ekpenyong et al.   Science Advances

Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms

(2017) Adam McGuinness et al.   Journal of Clinical Medicine

Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mouse hearts

(2017) Jonghae Lee et al.   PLoS One

The Role of Inflammation in β-cell Dedifferentiation

(2017) Thierry M. Nordmann et al.   Scientific Reports

Associations between multimorbidity, healthcare utilisation and health status: evidence from 16 European countries

(2016) Raffaele Palladino et al.   AGE AND AGEING

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

The Effect of Short-Term Hyperglycemia on the Innate Immune System

(2016) Nagham Jafar et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

The Microbiome and the Respiratory Tract

(2016) Robert P. Dickson et al.   Annual Review of Physiology

Effects of ageing and senescence on pancreatic β-cell function

(2016) A. Helman et al.   DIABETES OBESITY & METABOLISM

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation

(2016) Matthew Brook et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease

(2016) Andrew L. Durham et al.   Translational Research

TNF-αAutocrine Feedback Loops in Human Monocytes: The Pro- and Anti-Inflammatory Roles of the TNF-αReceptors Support the Concept of Selective TNFR1 BlockadeIn Vivo

(2016) Jennie M. Gane et al.   Journal of Immunology Research

Repurposing Treatments to Enhance Innate Immunity. Can Statins Improve Neutrophil Functions and Clinical Outcomes in COPD?

(2016) Georgia Walton et al.   Journal of Clinical Medicine

Local and Systemic Oxidative Stress and Glucocorticoid Receptor Levels in Chronic Obstructive Pulmonary Disease Patients

(2016) Mian Zeng et al.   Canadian Respiratory Journal

Role of free radical in atherosclerosis, diabetes and dyslipidaemia: larger-than-life

(2015) Randhir Singh et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney

(2015) Kai Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Exposure to cigarette smoke downregulatesβ2-adrenergic receptor expression and upregulates inflammation in alveolar macrophages

(2015) Wei Wang et al.   INHALATION TOXICOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Association between serum interleukin-6 concentrations and chronic obstructive pulmonary disease: a systematic review and meta-analysis

(2015) Jia Wei et al.   PeerJ

The progression of comorbidity in IL-18 transgenic chronic obstructive pulmonary disease mice model

(2014) Shin-ichi Takenaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A straight neutrophil path to healthy aging?

(2014) P. H. Naccache et al.   BLOOD

Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages

(2014) H. J. Metcalfe et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

(2014) Yi Zhu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Network medicine, multimorbidity and the lung in the elderly

(2014) R. Faner et al.   EUROPEAN RESPIRATORY JOURNAL

TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: Crosstalk between NF-κB and PPAR-γ

(2014) Youzhi Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome

(2014) Charlotte Summers et al.   THORAX

Cigarette-smoke-induced priming of neutrophils from smokers and non-smokers for increased oxidative burst response is mediated by TNF-α

(2014) Bärbel Friedrichs et al.   TOXICOLOGY IN VITRO

Simvastatin to modify neutrophil function in older patients with septic pneumonia (SNOOPI): study protocol for a randomised placebo-controlled trial

(2014) Hannah Greenwood et al.   Trials

The mediating role of cytokine IL-6 on the relationship of FEV1 upon 6-minute walk distance in chronic obstructive pulmonary disease

(2014) Simonetta Baldi et al.   International Journal of Chronic Obstructive Pulmonary Disease

Adipokines as mediators of endothelial function and atherosclerosis

(2013) George Ntaios et al.   ATHEROSCLEROSIS

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

(2013) E. Sapey et al.   BLOOD

Immunity, atherosclerosis and cardiovascular disease

(2013) Johan Frostegård   BMC Medicine

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Oxidative Stress in COPD

(2013) Paul A. Kirkham et al.   CHEST

Cardiovascular Comorbidity in COPD

(2013) Hana Müllerova et al.   CHEST

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Cardiovascular effects of tumour necrosis factor α antagonism in patients with acute myocardial infarction: a first in human study

(2013) Gareth J Padfield et al.   HEART

Reactive Oxygen Species in Peripheral Blood and Sputum Neutrophils During Bacterial and Nonbacterial Acute Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Mindaugas Vaitkus et al.   INFLAMMATION

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

RNA pulsed dendritic cells: An approach for cancer immunotherapy

(2013) Neeraj Kumar Garg et al.   VACCINE

Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics

(2013) Akiko Mammoto et al.   Nature Communications

Characteristics and outcomes of chronic obstructive pulmonary disease in never smokers in Denmark: a prospective population study

(2013) Mette Thomsen et al.   Lancet Respiratory Medicine

Concepts of comorbidities, multiple morbidities, complications, and their clinical epidemiologic analogs

(2013) Anne Ording et al.   Clinical Epidemiology

Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people

(2012) D. Baylis et al.   AGE

Effect of 1-year anti-TNF-α therapy on aortic stiffness, carotid atherosclerosis, and calprotectin in inflammatory arthropathies: a controlled study

(2012) Kristin Angel et al.   AMERICAN JOURNAL OF HYPERTENSION

Overexpression of Tumor Necrosis Factor-α in the Lungs Alters Immune Response, Matrix Remodeling, and Repair and Maintenance Pathways

(2012) Errol M. Thomson et al.   AMERICAN JOURNAL OF PATHOLOGY

Angiogenic neutrophils: a novel subpopulation paradigm

(2012) E. Kolaczkowska et al.   BLOOD

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

DNA Damage and Repair in Atherosclerosis: Current Insights and Future Perspectives

(2012) Tiziana Cervelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study

(2012) Karen Barnett et al.   LANCET

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity

(2012) M. Beyrau et al.   Open Biology

Behavioral and Structural Differences in Migrating Peripheral Neutrophils from Patients with Chronic Obstructive Pulmonary Disease

(2011) Elizabeth Sapey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

S100A9 Differentially Modifies Phenotypic States of Neutrophils, Macrophages, and Dendritic Cells

(2011) Michelle M. Averill et al.   CIRCULATION

Pulmonary Artery Smooth Muscle Cell Senescence Is a Pathogenic Mechanism for Pulmonary Hypertension in Chronic Lung Disease

(2011) Hibo Noureddine et al.   CIRCULATION RESEARCH

Does Therapy With Anti-TNF-  Improve Glucose Tolerance and Control in Patients With Type 2 Diabetes?

(2011) M. Gupta-Ganguli et al.   DIABETES CARE

Chemokine release by neutrophils in chronic obstructive pulmonary disease

(2011) Kristin Blidberg et al.   Innate Immunity

Genetics of leukocyte telomere length and its role in atherosclerosis

(2011) Abraham Aviv   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk

(2010) Peter Willeit et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High Neutrophil Numbers in Human Carotid Atherosclerotic Plaques Are Associated With Characteristics of Rupture-Prone Lesions

(2010) Mihaela G. Ionita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glucocorticosteroids: current and future directions

(2010) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY

Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications

(2010) Corey E. Tabit et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Persistent High Glucose Concentrations Alter the Regenerative Potential of Mesenchymal Stem Cells

(2010) Christopher Cramer et al.   STEM CELLS AND DEVELOPMENT

Systemic inflammation and comorbidity in COPD: a result of 'overspill' of inflammatory mediators from the lungs? Review of the evidence

(2010) N. J. Sinden et al.   THORAX

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE−/− mice

(2009) Courtney P. Judkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Shortened Telomeres in Circulating Leukocytes of Patients with Chronic Obstructive Pulmonary Disease

(2009) Laurent Savale et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Imbalances Between Interleukin-1 and Tumor Necrosis Factor Agonists and Antagonists in Stable COPD

(2009) Elizabeth Sapey et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation

(2009) Katja C. Weisel et al.   MEDIATORS OF INFLAMMATION

Somatic DNA alterations in lung epithelial barrier cells in COPD patients

(2009) Katerina D. Samara et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Smoking and Chronic Obstructive Pulmonary Disease (COPD). Parallel Epidemics of the 21st Century

(2009) Rafael Laniado-Laborín   International Journal of Environmental Research and Public Health

Role of HDAC2 in the Pathophysiology of COPD

(2008) Peter J. Barnes   Annual Review of Physiology

Oxidative stress: the vulnerable β-cell

(2008) Sigurd Lenzen   BIOCHEMICAL SOCIETY TRANSACTIONS

HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells

(2008) Xiaocen Kong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TNF-α antagonists and the prevention of hospitalisation for chronic obstructive pulmonary disease

(2007) Samy Suissa et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Inter-relationships between inflammatory markers in patients with stable COPD with bronchitis: intra-patient and inter-patient variability

(2007) E Sapey et al.   THORAX