Priming and de-priming of neutrophil responses in vitro and in vivo

Endocytosis is required for exocytosis and priming of respiratory burst activity in human neutrophils

(2017) T. Michael Creed et al.   INFLAMMATION RESEARCH

Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis

(2017) Kenneth R. McLeish et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Phenotype Correlates With Postoperative Inflammatory Outcomes in Infants Undergoing Cardiopulmonary Bypass

(2017) Jody N. Huber et al.   Pediatric Critical Care Medicine

L-selectin mechanochemistry restricts neutrophil priming in vivo

(2017) Zhenghui Liu et al.   Nature Communications

Multiple Phenotypic Changes Define Neutrophil Priming

(2017) Irina Miralda et al.   Frontiers in Cellular and Infection Microbiology

Mechanical deformation induces depolarization of neutrophils

(2017) Andrew E. Ekpenyong et al.   Science Advances

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

(2016) Jatinder K. Juss et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase

(2016) Renee M Potera et al.   Innate Immunity

Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation

(2016) Jennifer L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis

(2016) Laura C. Whitmore et al.   JOURNAL OF IMMUNOLOGY

Hypoxia upregulates neutrophil degranulation and potential for tissue injury

(2016) Kim Hoenderdos et al.   THORAX

Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis

(2016) Qing Liang et al.   Scientific Reports

Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo

(2016) Laura J. Hoodless et al.   Scientific Reports

Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation

(2015) Tamara Hornstein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microbe-dependent lymphatic migration of neutrophils modulates lymphocyte proliferation in lymph nodes

(2015) Henry R. Hampton et al.   Nature Communications

The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

(2014) Rachel Bayley et al.   ANNALS OF THE RHEUMATIC DISEASES

TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury

(2014) Jianwen Bai et al.   Innate Immunity

Platelet-Activating Factor-Mediated Endosome Formation Causes Membrane Translocation of p67phox and p40phox That Requires Recruitment and Activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3-Kinase in Human Neutrophils

(2014) N. J. D. McLaughlin et al.   JOURNAL OF IMMUNOLOGY

Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome

(2014) Charlotte Summers et al.   THORAX

Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation

(2013) M. Hurtado-Nedelec et al.   HAEMATOLOGICA

Class I Phosphoinositide-3-Kinases and Src Kinases Play a Nonredundant Role in Regulation of Adhesion-Independent and -Dependent Neutrophil Reactive Oxygen Species Generation

(2013) L. Fumagalli et al.   JOURNAL OF IMMUNOLOGY

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

(2013) C D Lucas et al.   Mucosal Immunology

RNA-Seq Reveals Activation of Both Common and Cytokine-Specific Pathways following Neutrophil Priming

(2013) Helen L. Wright et al.   PLoS One

Inhibition of Neutrophil Exocytosis Ameliorates Acute Lung Injury in Rats

(2013) Silvia M. Uriarte et al.   SHOCK

Delayed apoptosis by neutrophils from COPD patients is associated with altered bak, bcl-xl, and mcl-1 mRNA expression

(2012) Jisong Zhang et al.   Diagnostic Pathology

Endotoxin Priming of Neutrophils Requires Endocytosis and NADPH Oxidase-dependent Endosomal Reactive Oxygen Species

(2012) Fred S. Lamb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide and hemorrhagic shock cause systemic inflammation by different mechanisms

(2012) K.J.P. van Wessem et al.   Journal of Trauma and Acute Care Surgery

Granule Exocytosis Contributes to Priming and Activation of the Human Neutrophil Respiratory Burst

(2011) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Role for Myeloid Nuclear Differentiation Antigen in the Regulation of Neutrophil Apoptosis during Sepsis

(2010) Nasser Fotouhi-Ardakani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Granulocyte/Macrophage Colony–Stimulating Factor Causes a Paradoxical Increase in the BH3-Only Pro-Apoptotic Protein Bim in Human Neutrophils

(2010) Andrew S. Cowburn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Induction of neutrophil respiratory burst by tumour necrosis factor-alpha; priming effect of solid-phase fibronectin and intervention of CD llb-CD18 integrins

(2010) P. DAPINO et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

(2010) Janesh Pillay et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Impaired Priming and Activation of the Neutrophil NADPH Oxidase in Patients with IRAK4 or NEMO Deficiency

(2009) Anjali Singh et al.   JOURNAL OF IMMUNOLOGY

Regulation of TNF-induced oxygen radical production in human neutrophils: role of δ-PKC

(2009) Laurie E. Kilpatrick et al.   JOURNAL OF LEUKOCYTE BIOLOGY