Review
Medicine, General & Internal
Filippos Triposkiadis, Andrew Xanthopoulos, Konstantinos Lampropoulos, Alexandros Briasoulis, Pantelis Sarafidis, John Skoularigis, Harisios Boudoulas
Summary: Multimorbidity, driven by an aging population, is the coexistence of multiple health conditions, including hypertension, heart disease, chronic kidney disease, anemia, etc., in elderly individuals. Regular exercise, salt restriction, statins, and blood pressure control are interventions that can delay arterial stiffness progression and decrease multimorbidity in the elderly.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Daisuke Kato, Ichiro Kawachi, Junko Saito, Naoki Kondo
Summary: This study compared the prediction of mortality among older Japanese adults between complex multimorbidity (CMM) and conventional multimorbidity (MM), finding that both CMM and MM similarly predict mortality in older adults. Further replication studies with larger samples are needed to confirm these findings.
Article
Multidisciplinary Sciences
Ahmed Alboksmaty, Sonia Kumar, Ravi Parekh, Paul Aylin
Summary: This study investigated how UK COVID-19 policies have affected the management and safety of complex elderly patients at the primary care level in North West London. Fourteen GPs participated in individual semi-structured interviews, discussing the impact of COVID-19 policies on patient behavior, work conditions, and clinical practice. Insights from the GPs highlighted changes in primary care at various levels, the involvement of GPs in policy making, communication and coordination challenges, as well as stressors and worries.
Article
Nutrition & Dietetics
Sumiya Aihemaitijiang, Chen Ye, Mairepaiti Halimulati, Xiaojie Huang, Ruoyu Wang, Zhaofeng Zhang
Summary: This study developed and validated the Nutrition Literacy Questionnaire for the Chinese Elderly (NLQ-E), revealing a generally low level of nutrition literacy among the elderly participants. Additionally, a correlation was found between nutrition literacy scores and multimorbidity.
Article
Multidisciplinary Sciences
Julian C. Hong, Elizabeth R. Hauser, Thomas S. Redding, Kellie J. Sims, Ziad F. Gellad, Meghan C. O'Leary, Terry Hyslop, Ashton N. Madison, Xuejun Qin, David Weiss, A. Jasmine Bullard, Christina D. Williams, Brian A. Sullivan, David Lieberman, Dawn Provenzale
Summary: The study used a directed network graph to analyze comorbidities in a cohort of healthy veterans undergoing screening colonoscopy, identifying relationships between chronic diseases and visualizing the development of comorbidities over time. Top hub diseases included ischemic heart disease, while top authority diagnoses were acute kidney failure and hypertensive chronic kidney failure. The findings may help prioritize healthcare strategies and personalized care for aging veteran populations.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Davide L. Vetrano, Cecilia Damiano, Clare Tazzeo, Alberto Zucchelli, Alessandra Marengoni, Hao Luo, Maria Beatrice Zazzara, Hein van Hout, Graziano Onder
Summary: The study aimed to analyze multimorbidity patterns among older individuals living in nursing homes and investigate their association with mortality, taking into account functional status. The results showed that different multimorbidity patterns were differently associated with mortality, with the heart diseases and dementia with sensory impairments patterns being associated with increased mortality risk. As the specific multimorbidity expression increased, the risk of mortality also increased.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
P. Troy Teo, Amishi Bajaj, James Randall, Bin Lou, Jainil Shah, Mahesh Gopalakrishnan, Ali Kamen, Mohamed E. Abazeed
Summary: By studying the impact of tumor motion on the prediction of local failure risk after lung SBRT using DL models, it was found that DL scores derived from 4D CT images vary in a deterministic, sinusoidal trajectory in phase with the respiratory cycle. This indicates that DL models of tumors in motion can be robust and guide standardization processes in clinical translation for lung cancer patients.
Article
Clinical Neurology
Li Tong, Liyuan Pu, Xuecan Guo, Mengzi Sun, Feng Guo, Saisai Zhao, Wenhui Gao, Lina Jin
Summary: The study found a positive correlation between multimorbidity and depression status, with a higher prevalence of multimorbidity as depression status increased, especially in females, the young, and middle-aged individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geriatrics & Gerontology
Manuela Kanat, Jonas Schaefer, Laura Kivelitz, Joerg Dirmaier, Sebastian Voigt-Radloff, Bernhard Heimbach, Manuela Glattacker
Summary: Older patients with multimorbidity have a positive view towards patient-centered care, and the integrative PC model's dimensions are confirmed for this specific population. When targeting this population, some dimensions will be complemented.
Article
Health Care Sciences & Services
Oksoo Kim, Hyunju Dan
Summary: This study investigated the daily life experiences of elderly women with diabetes and multimorbidity living in elderly couple households in Korea. The findings revealed that these women considered their diseases as part of the aging process and continued to fulfill their caregiving roles for their husbands and themselves in order to avoid burdening their adult children.
Article
Chemistry, Multidisciplinary
Silvia Giovannini, Chiara Iacovelli, Claudia Loreti, Augusto Fusco, Vincenza Amoruso, Cristina Cuccagna, Lorenzo Biscotti, Luca Padua, Letizia Castelli
Summary: Frailty is a condition characterized by increased vulnerability and a risk factor for disability. With the increasing population of older adults, frailty and aging have become important social and health topics. Hospitalized elderly patients often have multiple comorbidities, leading to prolonged hospital stays and increased risks. Rehabilitation treatment plays a crucial role in improving disability, independence, and self-sufficiency among older inpatients.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Chaoyi Chen, Zhanchun Feng, Qian Fu, Jia Wang, Zehao Zheng, Hao Chen, Da Feng
Summary: The study conducted in Hubei province, China, found a high prevalence of polypharmacy among hospitalized patients aged 50 and above. Female patients, those with more chronic diseases, taking Chinese medicine, high decision involvement, and depression were identified as key predictors associated with polypharmacy in logistic regression analysis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Yawen Lin, Yuduan Hu, Jianhui Guo, Mingjun Chen, Xingyan Xu, Yeying Wen, Le Yang, Shaowei Lin, Huangyuan Li, Siying Wu
Summary: Sleep duration and quality are associated with multi morbidity in the elderly, highlighting the importance of normal nighttime sleep duration and good sleep quality in preventing multi morbidity.
Article
Pharmacology & Pharmacy
Przemyslaw Kardas, Alpana Mair, Derek Stewart, Pawel Lewek, SIMPATHY Consortium
Summary: This study evaluated polypharmacy management programs in the elderly in Europe and created a benchmarking application based on survey results. The findings showed that these programs primarily focused on primary care, with pharmacists and primary care doctors being the main providers. However, the programs scored low in cost-effectiveness due to a lack of data.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Guiying Dong, Zi-Chao Zhang, Jianfeng Feng, Xing-Ming Zhao
Summary: Exploring multimorbidity relationships among diseases is crucial for precise diagnosis and treatment. MorbidGCN, a graph convolutional network model, integrates population phenotypes and disease networks for multimorbidity prediction and outperforms other methods in identifying new multimorbidities.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Critical Care Medicine
Tessa M. Kole, Elise Vanden Berghe, Monica Kraft, Judith M. Vonk, Martijn C. Nawijn, Salman Siddiqui, Kai Sun, Leonardo M. Fabbri, Klaus F. Rabe, Kian Fan Chung, Gabriele Nicolini, Alberto Papi, Chris Brightling, Dave Singh, Thys van der Molen, Sven-Erik Dahlen, Alvar Agusti, Rosa Faner, Jadwiga A. Wedzicha, Gavin C. Donaldson, Ian M. Adcock, Lies Lahousse, Huib A. M. Kerstjens, Maarten van den Berge
Summary: This post-hoc analysis investigates the determinants, clinical implications, and outcome of persistent airflow limitation (PAL) in patients with asthma. The study reveals that PAL is not only present in severe asthma, but also in a considerable proportion of patients with milder disease. In patients with mild asthma, PAL is associated with eosinophilic inflammation and a higher risk of exacerbations, suggesting the need for increased treatment intensity.
LANCET RESPIRATORY MEDICINE
(2023)
Letter
Critical Care Medicine
Nuria Olvera, Sandra Casas, Judith M. Vonk, Tamara Garcia, H. Marike Boezen, Maarten van den Berge, Alvar Agusti, Rosa Faner
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Kilian Vellve, Alvaro Sepulveda-Martinez, Merida Rodriguez-Lopez, Francesca Crovetto, Gabriel Bernardino, Felip Burgos, Rosa Faner, Alvar Agusti, Bart Bijnens, Eduard Gratacos, Fatima Crispi, Isabel Blanco
Article
Critical Care Medicine
Gang Wang, Jenny Hallberg, Rosa Faner, Hans-Jacob Koefoed, Simon Kebede Merid, Susanna Klevebro, Sophia Bjorkander, Olena Gruzieva, Goran Pershagen, Marianne van Hage, Stefano Guerra, Matteo Bottai, Antonios Georgelis, Ulrike Gehring, Anna Bergstrom, Judith M. Vonk, Inger Kull, Gerard H. Koppelman, Alvar Agusti, Erik Melen
Summary: Recent evidence emphasizes the significance of optimal lung development during childhood for lifelong health. This study explored the plasticity of individual lung function states during childhood and found that catch-up and growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction in adulthood.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Gang Wang, Jenny Hallberg, Rosa Faner, Alvar Agusti, Erik Melen
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Alvar Agusti, Bartolome R. Celli, Gerard J. Criner, David Halpin, Antonio Anzueto, Peter Barnes, Jean Bourbeau, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Kevin Mortimer, Alberto Papi, Ian Pavord, Nicolas Roche, Sundeep Salvi, Don D. Sin, Dave Singh, Robert Stockley, M. Victorina Lopez Varela, Jadwiga A. Wedzicha, Claus F. Vogelmeier
Letter
Respiratory System
Tamara Cruz, Nuria Mendoza, Gema M. Lledo, Lidia Perea, Nuria Albacar, Alvar Agusti, Jacobo Sellares, Oriol Sibila, Rosa Faner
Letter
Critical Care Medicine
Miguel Angel Martinez-Garcia, Alvar Agusti
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Surya P. Bhatt, Alvar Agusti, Mona Bafadhel, Stephanie A. Christenson, Jessica Bon, Gavin C. Donaldson, Don D. Sin, Jadwiga A. Wedzicha, Fernando J. Martinez
Summary: Chronic obstructive pulmonary disease is a major health problem with acute exacerbations that have limited improvements in outcomes. It is important to identify different etioendophenotypes to develop novel therapies.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nuria Mendoza, Sandra Casas-Recasens, Nuria Olvera, Fernanda Hernandez-Gonzalez, Tamara Cruz, Nuria Albacar, Xavier Alsina-Restoy, Alejandro Frino-Garcia, Gemma Lopez-Saiz, Lucas Robres, Mauricio Rojas, Alvar Agusti, Jacobo Sellares, Rosa Faner
Summary: The immune response plays a controversial role in the development of idiopathic pulmonary fibrosis (IPF). This study found that IPF patients have distinct immune phenotypes in their peripheral blood, which are associated with disease severity and progression. The abnormalities in immune cell populations, particularly cytotoxic cells, are stable over time in IPF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Carlota Rodriguez Garcia, Alberto Ruano-Ravina, Monica Perez Rios, Lucia Martin Gisbert, Leonor Varela-Lema, Cristina Candal-Pedreira, Cristina Represas-Represas, Julia Rey-Brandariz, Luis Valdes-Cuadradoa, Alvar Agusti
Summary: Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death worldwide. While smoking is a major risk factor, COPD also occurs in individuals who have never smoked (NS). However, there is limited evidence on the risk factors, clinical characteristics, and natural history of COPD in NS. This study aimed to address this knowledge gap through a systematic review of the literature.
RESPIRATORY MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
D. Pellegrino, S. Casas-Recasens, R. Faner, P. Palange, A. Agusti
Summary: The term GETomics refers to the concept that human health and disease are the result of dynamic gene-environment interactions occurring throughout a person's lifetime. This approach has led to a dramatic shift in our understanding of chronic obstructive pulmonary disease (COPD), as it is not solely caused by smoking and affects both genders and different age groups. By applying a GETomics approach, new perspectives on the relationship between COPD, exercise limitation, and aging can be gained.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Caspar Schiffers, Rosa Faner, Alina Ofenheimer, Owat Sunanta, Patricia Puchhammer, Tobias Mraz, Marie-Kathrin Breyer, Otto Chris Burghuber, Sylvia Hartl, Alvar Agusti, Robab Breyer-Kohansal
Summary: This study investigated the prevalence and characteristics of individuals with supranormal FEV1 or FVC values in different age groups. It found that approximately 3% of the general population have supranormal values, which are associated with better health markers. Factors such as female sex, higher muscle mass, less diabetes, and fewer respiratory symptoms are consistently associated with supranormal values.
Article
Cell Biology
Fernanda Hernandez-Gonzalez, Neus Prats, Valentina Ramponi, Jose Alberto Lopez-Dominguez, Kathleen Meyer, Monica Aguilera, Maria Isabel Munoz Martin, Daniel Martinez, Alvar Agusti, Rosa Faner, Jacobo Sellares, Federico Pietrocola, Manuel Serrano
Summary: Cell senescence has emerged as a potential mechanism in fibrosing interstitial lung diseases, and senescent human fibroblasts can trigger progressive fibrogenic reaction in the lungs. The secretome of senescent fibroblasts is pro-senescence and pro-fibrotic, while non-senescent fibroblasts lack these activities. Drugs like navitoclax, nintedanib, and pirfenidone can ameliorate lung fibrosis induced by senescent fibroblasts in mice.
Article
Respiratory System
Erin L. Tomaszewski, Mark J. Atkinson, Christer Janson, Niklas Karlsson, Barry Make, David Price, Helen K. Reddel, Claus F. Vogelmeier, Hana Mullerova, Paul W. Jones
Summary: The Chronic Airways Assessment Test (CAAT), a questionnaire adapted for patients with asthma and/or COPD, has been shown to be consistent and accurate in measuring overall health status in these patients.
RESPIRATORY RESEARCH
(2023)