Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells

Changes in Zn homeostasis during long term culture of primary endothelial cells and effects of Zn on endothelial cell senescence

(2017) Marco Malavolta et al.   EXPERIMENTAL GERONTOLOGY

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

The apoptotic and autophagic properties of two natural occurring prodrugs, hyperoside and hypoxoside, against pancreatic cancer cell lines

(2016) Gerhardt J. Boukes et al.   BIOMEDICINE & PHARMACOTHERAPY

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Quercetin: A flavonol with multifaceted therapeutic applications?

(2015) Gabriele D'Andrea   FITOTERAPIA

Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX

(2015) Marissa V Powers et al.   Oncotarget

Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model

(2014) Husam Dabbagh-Bazarbachi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype

(2012) Geunwon Kim et al.   AGING CELL

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

MicroRNA profiling of diverse endothelial cell types

(2011) Matthew N McCall et al.   BMC Medical Genomics

17β-Estradiol, Aging, Inflammation, and the Stress Response in the Female Heart

(2011) James P. Stice et al.   ENDOCRINOLOGY

Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells

(2011) Cigir Biray Avci et al.   Hematology

Protective effects of hyperoside against human umbilical vein endothelial cell damage induced by hydrogen peroxide

(2011) Zi-lin Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids

(2010) Bernice Wright et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155☆

(2010) Christine Boesch-Saadatmandi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Flavonoid Quercetin Transiently Inhibits the Activity of Taxol and Nocodazole Through Interference With the Cell Cycle

(2010) Temesgen Samuel et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Modulation of Hsf1 activity by novobiocin and geldanamycin

(2009) Renaud Conde et al.   Biochemistry and Cell Biology

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Health effects of quercetin: From antioxidant to nutraceutical

(2008) Agnes W. Boots et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cellular senescence and organismal aging

(2008) Jessie C. Jeyapalan et al.   MECHANISMS OF AGEING AND DEVELOPMENT