Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma

Reactive oxygen species: a volatile driver of field cancerization and metastasis

(2019) Zehuan Liao et al.   Molecular Cancer

Harnessing Microglia and Macrophages for the Treatment of Glioblastoma

(2019) Ioanna Prionisti et al.   Frontiers in Pharmacology

Glutathione-Depleting Pro-Oxidant as a Selective Anticancer Therapeutic Agent

(2019) Donghyuck Yoo et al.   ACS Omega

Extracellular and macropinocytosis internalized ATP work together to induce epithelial–mesenchymal transition and other early metastatic activities in lung cancer

(2019) Yanyang Cao et al.   Cancer Cell International

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

(2019) Anastasiya V. Snezhkina et al.   Oxidative Medicine and Cellular Longevity

Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

(2019) Weihua Zhou et al.   Cancers

Localized metabolomic gradients in patient-derived xenograft models of glioblastoma

(2019) Elizabeth C Randall et al.   CANCER RESEARCH

Genomic and Phenotypic Characterization of a Broad Panel of Patient-Derived Xenografts Reflects the Diversity of Glioblastoma

(2019) Rachael A. Vaubel et al.   CLINICAL CANCER RESEARCH

The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells

(2018) Catherine J. Libby et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Oxidative stress and mitochondrial adaptive shift during pituitary tumoral growth

(2018) Maria Eugenia Sabatino et al.   FREE RADICAL BIOLOGY AND MEDICINE

Extracellular matrix and traumatic brain injury

(2018) Naijil George et al.   JOURNAL OF NEUROSCIENCE RESEARCH

YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma

(2018) Xin Zhang et al.   Journal of Translational Medicine

Regulation of ATP utilization during metastatic cell migration by collagen architecture

(2018) Matthew R. Zanotelli et al.   MOLECULAR BIOLOGY OF THE CELL

Efficacy of the MDM2 inhibitor SAR405838 in glioblastoma is limited by poor distribution across the blood-brain barrier

(2018) Minjee Kim et al.   MOLECULAR CANCER THERAPEUTICS

Effects of radiation on the metastatic process

(2018) Nora Sundahl et al.   MOLECULAR MEDICINE

Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment

(2018) Nicole Osier et al.   MOLECULAR NEUROBIOLOGY

Role of Ionizing Radiation in Neurodegenerative Diseases

(2018) Neel K. Sharma et al.   Frontiers in Aging Neuroscience

Ageing: from inflammation to cancer

(2018) Giulia C. Leonardi et al.   Immunity & Ageing

Immune Microenvironment in Glioblastoma Subtypes

(2018) Zhihong Chen et al.   Frontiers in Immunology

Advances in Radiotherapy for Glioblastoma

(2018) Justin Mann et al.   Frontiers in Neurology

Pharmacological ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer

(2018) Matthew S Alexander et al.   CANCER RESEARCH

The Mechanism of Exosomes Function in Neurological Diseases: a progressive review

(2018) Mengchen Yuan et al.   CURRENT PHARMACEUTICAL DESIGN

New strategies for targeting glucose metabolism-mediated acidosis for colorectal cancer therapy

(2018) Gang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type

(2018) Sindhu K. Madathil et al.   Frontiers in Neurology

Human Glioma Migration and Infiltration Properties as a Target for Personalized Radiation Medicine

(2018) Michaela Wank et al.   Cancers

Radiation-Induced Alterations in the Recurrent Glioblastoma Microenvironment: Therapeutic Implications

(2018) Kshama Gupta et al.   Frontiers in Oncology

Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization

(2017) Anita Thyagarajan et al.   INTEGRATIVE CANCER THERAPIES

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

HMDB 4.0: the human metabolome database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Extracellular ATP, as an energy and phosphorylating molecule, induces different types of drug resistances in cancer cells through ATP internalization and intracellular ATP level increase

(2017) Xuan Wang et al.   Oncotarget

Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain

(2017) Katalin Lumniczky et al.   Frontiers in Immunology

Radiation induces progenitor cell death, microglia activation and blood-brain barrier damage in the juvenile rat cerebellum

(2017) Kai Zhou et al.   Scientific Reports

Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells

(2017) Sajad Dar et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Simultaneous Analysis of Major Coenzymes of Cellular Redox Reactions and Energy Using ex Vivo 1H NMR Spectroscopy

(2016) G. A. Nagana Gowda et al.   ANALYTICAL CHEMISTRY

Delayed activation of human microglial cells by high dose ionizing radiation

(2016) Hongxin Chen et al.   BRAIN RESEARCH

Mitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds

(2016) Lalita Guntuku et al.   Current Neuropharmacology

Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling

(2016) Michael J. Moravan et al.   Journal of Neuroinflammation

Radiobiology of hypofractionated stereotactic radiotherapy: what are the optimal fractionation schedules?

(2016) Yuta Shibamoto et al.   JOURNAL OF RADIATION RESEARCH

The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis

(2016) Kazutaka Sumita et al.   MOLECULAR CELL

Pathophysiological Responses in Rat and Mouse Models of Radiation-Induced Brain Injury

(2016) Lianhong Yang et al.   MOLECULAR NEUROBIOLOGY

The role of microglia and macrophages in glioma maintenance and progression

(2016) Dolores Hambardzumyan et al.   NATURE NEUROSCIENCE

Glycolysis and the pentose phosphate pathway are differentially associated with the dichotomous regulation of glioblastoma cell migration versus proliferation

(2016) Annegret Kathagen-Buhmann et al.   NEURO-ONCOLOGY

Heatmapper: web-enabled heat mapping for all

(2016) Sasha Babicki et al.   NUCLEIC ACIDS RESEARCH

Characterization of the serum metabolome following radiation treatment in patients with high-grade gliomas

(2016) Lina Mörén et al.   Radiation Oncology

Energy metabolism in the acquisition and maintenance of stemness

(2016) Clifford D.L. Folmes et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cranial irradiation induces transient microglia accumulation, followed by long-lasting inflammation and loss of microglia

(2016) Wei Han et al.   Oncotarget

Impacts of Ionizing Radiation on the Different Compartments of the Tumor Microenvironment

(2016) Natacha Leroi et al.   Frontiers in Pharmacology

The impact of high and low dose ionising radiation on the central nervous system

(2016) Calina Betlazar et al.   Redox Biology

Premature aging/senescence in cancer cells facing therapy: good or bad?

(2015) Llilians Calvo Gonzalez et al.   BIOGERONTOLOGY

Metabolic therapy: A new paradigm for managing malignant brain cancer

(2015) Thomas N. Seyfried et al.   CANCER LETTERS

Aging-like changes in the transcriptome of irradiated microglia

(2015) Matthew D. Li et al.   GLIA

Non-signalling energy use in the brain

(2015) Elisabeth Engl et al.   JOURNAL OF PHYSIOLOGY-LONDON

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

(2015) Emma L. James et al.   JOURNAL OF PROTEOME RESEARCH

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions

(2015) Sameer Agnihotri et al.   NEURO-ONCOLOGY

Radioprotectors and Radiomitigators for Improving Radiation Therapy: The Small Business Innovation Research (SBIR) Gateway for Accelerating Clinical Translation

(2015) Pataje G. S. Prasanna et al.   RADIATION RESEARCH

Blood Brain Barrier: A Challenge for Effectual Therapy of Brain Tumors

(2015) Arijit Bhowmik et al.   Biomed Research International

Warburg effect regulated by amphiregulin in the development of colorectal cancer

(2015) Sung Ouk Nam et al.   Cancer Medicine

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Proteins and Radiotherapy

(2014) Y. Zhang et al.   CLINICAL ONCOLOGY

The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?

(2014) J. Martin Brown et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Malignancy-associated metabolic profiling of human glioma cell lines using 1H NMR spectroscopy

(2014) Wei Shao et al.   Molecular Cancer

Differential expression of sirtuin family members in the developing, adult, and aged rat brain

(2014) Elena Sidorova-Darmos et al.   Frontiers in Aging Neuroscience

Pharmacological Doses of Daily Ascorbate Protect Tumors from Radiation Damage after a Single Dose of Radiation in an Intracranial Mouse Glioma Model

(2014) Carole Grasso et al.   Frontiers in Oncology

Can Dietary Antioxidants Reduce the Incidence of Brain Tumors?

(2013) S. A. Sheweita et al.   CURRENT DRUG METABOLISM

GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients

(2013) Satoshi Nakamizo et al.   JOURNAL OF NEURO-ONCOLOGY

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Quantitating the subtleties of microglial morphology with fractal analysis

(2013) Audrey Karperien et al.   Frontiers in Cellular Neuroscience

How does cancer cell metabolism affect tumor migration and invasion?

(2013) Tianyu Han et al.   Cell Adhesion & Migration

Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo

(2013) Adarsh Shankar et al.   Chinese Journal of Cancer

Ascorbic acid: Chemistry, biology and the treatment of cancer

(2012) Juan Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Irradiation Alters MMP-2/TIMP-2 System and Collagen Type IV Degradation in Brain

(2012) Won Hee Lee et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

1H NMR Metabolomics Analysis of Glioblastoma Subtypes

(2012) Miroslava Cuperlovic-Culf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The Spider Effect: Morphological and Orienting Classification of Microglia in Response to Stimuli in Vivo

(2012) Rahul A. Jonas et al.   PLoS One

Microenvironment and Radiation Therapy

(2012) Michio Yoshimura et al.   Biomed Research International

RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration

(2011) Matthieu Rousseau et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

pH optimization for a reliable quantification of brain tumor cell and tissue extracts with 1H NMR: focus on choline-containing compounds and taurine

(2010) O. Robert et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1

(2010) Jihuan Chen et al.   BEHAVIOURAL BRAIN RESEARCH

Commentary on effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-Year analysis of the EORTC-NCIC trial (Lancet Oncol. 2009;10:459-466)

(2010) Ute Linz   CANCER

Metabolomic Patterns in Glioblastoma and Changes during Radiotherapy: A Clinical Microdialysis Study

(2010) Carl Wibom et al.   JOURNAL OF PROTEOME RESEARCH

Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury

(2010) D. Citrin et al.   ONCOLOGIST

Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide

(2010) Giuseppe Minniti et al.   RADIOTHERAPY AND ONCOLOGY

FiehnLib: Mass Spectral and Retention Index Libraries for Metabolomics Based on Quadrupole and Time-of-Flight Gas Chromatography/Mass Spectrometry

(2009) Tobias Kind et al.   ANALYTICAL CHEMISTRY

Role of microglial redox balance in modulation of neuroinflammation

(2009) Nadia G Innamorato et al.   CURRENT OPINION IN NEUROLOGY

Metabolic alterations: A biomarker for radiation-induced normal brain injury-an MR spectroscopy study

(2009) P.C. Sundgren et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

MRI of late microstructural and metabolic alterations in radiation-induced brain injuries

(2009) Kevin C. Chan et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Purinergic systems in microglia

(2008) K. Inoue   CELLULAR AND MOLECULAR LIFE SCIENCES

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurotrophic Effects of Extracellular Guanosine

(2008) Michel Rathbone et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA