Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1869, Issue 2, Pages 175-188Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2018.01.004
Keywords
Glioblastoma; Tumor initiating cell; Cancer stem cell; Metabolism; Therapeutic resistance; Novel therapeutics
Categories
Funding
- National Institutes of Health [R21NS096531]
- University of Alabama at Birmingham
- Department of Cell, Developmental and Integrative Biology
- Comprehensive Cancer Center
- Civitan International Research Center for Glial Biology in Medicine
- Center for Free Radical Biology
- Neuro-Oncology Brain SPORE
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De-regulated cellular energetics is an emerging hallmark of cancer with alterations to glycolysis, oxidative phosphorylation, the pentose phosphate pathway, lipid oxidation and synthesis and amino acid metabolism. Understanding and targeting of metabolic reprogramming in cancers may yield new treatment options, but metabolic heterogeneity and plasticity complicate this strategy. One highly heterogeneous cancer for which current treatments ultimately fail is the deadly brain tumor glioblastoma. Therapeutic resistance, within glioblastoma and other solid tumors, is thought to be linked to subsets of tumor initiating cells, also known as cancer stem cells. Recent profiling of glioblastoma and brain tumor initiating cells reveals changes in metabolism, as compiled here, that may be more broadly applicable. We will summarize the profound role for metabolism in tumor progression and therapeutic resistance and discuss current approaches to target glioma metabolism to improve standard of care.
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