Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii -Mediated Inflammation

(2018) Elise Burger et al.   Cell Host & Microbe

Bilirubin in the Liver–Gut Signaling Axis

(2018) Abdul-Rizaq Hamoud et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genetic Factors Interact With Tobacco Smoke to Modify Risk for Inflammatory Bowel Disease in Humans and Mice

(2017) Pankaj Yadav et al.   GASTROENTEROLOGY

Paneth Cell Alterations in the Development and Phenotype of Crohn’s Disease

(2017) Thaddeus S. Stappenbeck et al.   GASTROENTEROLOGY

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Erratum: Selective deletion of adipocytes, but not preadipocytes, by TNF-α through C/EBP- and PPARγ-mediated suppression of NF-κB

(2017) Minori Tamai et al.   LABORATORY INVESTIGATION

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

(2017) James C Lee et al.   NATURE GENETICS

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

(2017) Stefan Stender et al.   NATURE GENETICS

Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma

(2017) Mikaela A. Miller et al.   PLoS One

Temporal and Spatial Expression of Transforming Growth Factor-β after Airway Remodeling to Tobacco Smoke in Rats

(2016) Laura L. Hoang et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Genetics and Pathogenesis of Inflammatory Bowel Disease

(2016) Ta-Chiang Liu et al.   Annual Review of Pathology-Mechanisms of Disease

Environment and Genes: What Is the Interaction?

(2016) Richard S. Blumberg   DIGESTIVE DISEASES

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF

(2016) Ling-Shiang Chuang et al.   GASTROENTEROLOGY

Gut Microbial Diversity Is Reduced in Smokers with Crohnʼs Disease

(2016) Jorrit L. Opstelten et al.   INFLAMMATORY BOWEL DISEASES

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

(2016) Isabelle Cleynen et al.   LANCET

Accounting for reciprocal host–microbiome interactions in experimental science

(2016) Thaddeus S. Stappenbeck et al.   NATURE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine

(2016) Julie Tomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection

(2016) Anshu P. Gounder et al.   PLoS Pathogens

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

(2015) Monika Schaubeck et al.   GUT

Metagenomic Analysis of Crohnʼs Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers

(2015) Vicente Pérez-Brocal et al.   INFLAMMATORY BOWEL DISEASES

The Influence of Smoking on the Peri-Implant Microbiome

(2015) A.A. Tsigarida et al.   JOURNAL OF DENTAL RESEARCH

Host and microbiota interactions are critical for development of murine Crohn’s-like ileitis

(2015) M Roulis et al.   Mucosal Immunology

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

(2015) Clara Moon et al.   NATURE

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Smoking induces transcription of the heat shock protein system in the joints

(2014) Caroline Ospelt et al.   ANNALS OF THE RHEUMATIC DISEASES

Early life environment and natural history of inflammatory bowel diseases

(2014) Abra Y Guo et al.   BMC GASTROENTEROLOGY

Environmental Risk Factors for Inflammatory Bowel Diseases: A Review

(2014) Ashwin N. Ananthakrishnan   DIGESTIVE DISEASES AND SCIENCES

Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease

(2014) Tim Raine et al.   GUT

Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

(2014) Eriks Smagris et al.   HEPATOLOGY

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Spatial and Temporal Stability of Paneth Cell Phenotypes in Crohnʼs Disease

(2014) Ta-Chiang Liu et al.   INFLAMMATORY BOWEL DISEASES

Agonistic induction of PPARγ reverses cigarette smoke–induced emphysema

(2014) Ming Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide

(2014) B O Schroeder et al.   Mucosal Immunology

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation

(2013) Bo Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway

(2013) James C. Lee et al.   CELL

Genetic Variants Synthesize to Produce Paneth Cell Phenotypes That Define Subtypes of Crohn's Disease

(2013) Kelli L. VanDussen et al.   GASTROENTEROLOGY

Many Inflammatory Bowel Disease Risk Loci Include Regions That Regulate Gene Expression in Immune Cells and the Intestinal Epithelium

(2013) Michal Mokry et al.   GASTROENTEROLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

A Prospective Study of Cigarette Smoking and the Risk of Inflammatory Bowel Disease in Women

(2012) Leslie M Higuchi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Tracking Cell Lineage to Rediscover (again) the Switch from Ciliated to Mucous Cells

(2011) Anand C. Patel et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Postoperative recurrent luminal Crohnʼs Disease: A systematic review

(2011) Peter De Cruz et al.   INFLAMMATORY BOWEL DISEASES

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

(2009) Tirumalai Rangasamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette Smoke Induces Nucleic-Acid Oxidation in Lung Fibroblasts

(2009) Gaetan Deslee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Rosiglitazone for Active Ulcerative Colitis: A Randomized Placebo-Controlled Trial

(2008) James D. Lewis et al.   GASTROENTEROLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE