Alveolar wars: The rise of in vitro models to understand human lung alveolar maintenance, regeneration, and disease

Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips

(2020) Kambez H. Benam et al.   Nature Protocols

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Advancements and Obstacles of CRISPR-Cas9 technology in Translational Research

(2019) Liting You et al.   Molecular Therapy-Methods & Clinical Development

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids

(2019) Yohei Korogi et al.   Stem Cell Reports

Engineering Microfluidic Organoid-on-a-Chip Platforms

(2019) Fang Yu et al.   Micromachines

Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour

(2019) Khondoker M. Akram et al.   Nature Communications

Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

(2019) Qiaozhen Liu et al.   NATURE GENETICS

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease

(2019) Herbert B Schiller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo

(2019) Isabelle Salwig et al.   EMBO JOURNAL

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

(2019) Alexandros Strikoudis et al.   Cell Reports

Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells

(2019) Anjali Jacob et al.   Nature Protocols

Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

(2019) Sandra Lawrynowicz Leibel et al.   Scientific Reports

The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells

(2018) Jiao Li et al.   DEVELOPMENTAL CELL

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate

(2018) Yanjie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

Regeneration of functional alveoli by adult human SOX9+ airway basal cell transplantation

(2018) Qiwang Ma et al.   Protein & Cell

In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells

(2018) Alyssa J. Miller et al.   Stem Cell Reports

Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype

(2018) Chaoqun Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis

(2018) Shin-Ichi Nureki et al.   JOURNAL OF CLINICAL INVESTIGATION

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

(2018) William J. Zacharias et al.   NATURE

Erratum: Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

Medium throughput breathing human primary cell alveolus-on-chip model

(2018) Janick D. Stucki et al.   Scientific Reports

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lung bioengineering

(2018) Juan J. Uriarte et al.   Current Opinion in Organ Transplantation

Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture

(2018) Ana Luisa Rodrigues Toste de Carvalho et al.   DEVELOPMENT

Pirfenidone improves survival in IPF: results from a real-life study

(2018) George A. Margaritopoulos et al.   BMC Pulmonary Medicine

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

(2017) Yuki Yamamoto et al.   NATURE METHODS

Mesenchymal Stromal Cell Therapy for Chronic Lung Allograft Dysfunction: Results of a First-in-Man Study

(2017) Daniel C. Chambers et al.   Stem Cells Translational Medicine

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

(2017) Marko Z Nikolić et al.   eLife

Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality

(2017) Vanessa Neuhaus et al.   Journal of Occupational Medicine and Toxicology

Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications

(2017) Peter W. Andrews et al.   Stem Cell Reports

Bronchopulmonary Dysplasia: Chronic Lung Disease of Infancy and Long-Term Pulmonary Outcomes

(2017) Lauren Davidson et al.   Journal of Clinical Medicine

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

(2017) Aleksander Skardal et al.   Scientific Reports

A three-dimensional human model of the fibroblast activation that accompanies bronchopulmonary dysplasia identifies Notch-mediated pathophysiology

(2016) Jennifer M. S. Sucre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Confronting stem cell hype

(2016) T. Caulfield et al.   SCIENCE

Concise Review: The Bystander Effect: Mesenchymal Stem Cell-Mediated Lung Repair

(2016) Ulrika Blank Savukinas et al.   STEM CELLS

MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration

(2016) Zhe Liu et al.   Cell Reports

Evaluation of inflammatory and immune responses in long-term cultured human precision-cut lung slices

(2016) Angela Temann et al.   Human Vaccines & Immunotherapeutics

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids

(2016) Briana R Dye et al.   eLife

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD

(2016) Helen Kennelly et al.   Scientific Reports

Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses

(2015) Rui Liu et al.   ANTIVIRAL RESEARCH

Mesenchymal stem cells for therapeutic applications in pulmonary medicine

(2015) Collin T. Stabler et al.   BRITISH MEDICAL BULLETIN

How common is the lipid body-containing interstitial cell in the mammalian lung?

(2014) Daniel Tahedl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Airway Contractility in the Precision-Cut Lung Slice after Cryopreservation

(2014) Sonia R. Rosner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

p63+Krt5+ distal airway stem cells are essential for lung regeneration

(2014) Wei Zuo et al.   NATURE

Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS)

(2014) L. Lauenstein et al.   TOXICOLOGY IN VITRO

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

(2014) Shimpei Gotoh et al.   Stem Cell Reports

Role of alveolar macrophages in chronic obstructive pulmonary disease

(2014) Ross Vlahos   Frontiers in Immunology

Evidence for Scgb1a1+Cells in the Generation of p63+Cells in the Damaged Lung Parenchyma

(2013) Dahai Zheng et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Placebo-Controlled, Randomized Trial of Mesenchymal Stem Cells in COPD

(2013) Daniel J. Weiss et al.   CHEST

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small but Significant: Inter- and Intrapatient Variations in iPS Cell–based Disease Modeling

(2013) Malte Sgodda et al.   MOLECULAR THERAPY

Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

(2013) Vitor H Teixeira et al.   eLife

Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury

(2012) Tamás Dolinay et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Uses of Remnant Human Lung Tissue for Mechanical Stretch Studies

(2012) N. Davidovich et al.   Cellular and Molecular Bioengineering

The alveolar macrophages in asthma: a double-edged sword

(2012) J Balhara et al.   Mucosal Immunology

Influenza A(H1N1)pdm09 Virus Suppresses RIG-I Initiated Innate Antiviral Responses in the Human Lung

(2012) Wenxin Wu et al.   PLoS One

Genomic Differences Distinguish the Myofibroblast Phenotype of Distal Lung Fibroblasts from Airway Fibroblasts

(2011) Xiuxia Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection

(2011) Pooja A. Kumar et al.   CELL

Exploring lung physiology in health and disease with lung slices

(2011) Michael J. Sanderson   PULMONARY PHARMACOLOGY & THERAPEUTICS

Concise Review: Induced Pluripotent Stem Cells Versus Embryonic Stem Cells: Close Enough or Yet Too Far Apart?

(2011) Josipa Bilic et al.   STEM CELLS

Human Lung Parenchyma but Not Proximal Bronchi Produces Fibroblasts with Enhanced TGF-β Signaling and α-SMA Expression

(2010) Dmitri V. Pechkovsky et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HTII-280, a Biomarker Specific to the Apical Plasma Membrane of Human Lung Alveolar Type II Cells

(2010) Robert F. Gonzalez et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Epigenetic memory in induced pluripotent stem cells

(2010) K. Kim et al.   NATURE

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices

(2010) S. Switalla et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeted Injury of Type II Alveolar Epithelial Cells Induces Pulmonary Fibrosis

(2009) Thomas H. Sisson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model

(2009) Wenxin Wu et al.   VIROLOGY

Injury and Inflammation from Resuscitation of the Preterm Infant

(2008) Alan H. Jobe et al.   Neonatology