RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection

Core transcriptional regulatory circuits in prion diseases

(2020) Taek-Kyun Kim et al.   Molecular Brain

Astrocytes usurp neurons as a disease focus

(2019) Shane A. Liddelow et al.   NATURE NEUROSCIENCE

Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

(2019) Kristin Hartmann et al.   Acta Neuropathologica Communications

Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis

(2019) Jing Jin et al.   Acta Neuropathologica Communications

Microglia Are Critical in Host Defense against Prion Disease

(2018) James A. Carroll et al.   JOURNAL OF VIROLOGY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Microglia in prion diseases

(2017) Adriano Aguzzi et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Non-identical twins: Different faces of CR3 and CR4 in myeloid and lymphoid cells of mice and men

(2017) Anna Erdei et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Activation of microglia by retroviral infection correlates with transient clearance of prions from the brain but does not change incubation time

(2016) Christiane Muth et al.   BRAIN PATHOLOGY

Mechanisms of prion-induced neurodegeneration

(2016) Paula Saá et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Heatmapper: web-enabled heat mapping for all

(2016) Sasha Babicki et al.   NUCLEIC ACIDS RESEARCH

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Prion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion Strains

(2016) James A. Carroll et al.   PLoS Pathogens

Neurodegenerative Diseases: Expanding the Prion Concept

(2015) Lary C. Walker et al.   Annual Review of Neuroscience

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Defining the Microglia Response during the Time Course of Chronic Neurodegeneration

(2015) James E. Vincenti et al.   JOURNAL OF VIROLOGY

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

Ballgown bridges the gap between transcriptome assembly and expression analysis

(2015) Alyssa C Frazee et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains

(2015) Caihong Zhu et al.   NEUROBIOLOGY OF AGING

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

Age-related differences in neuroinflammatory responses associated with a distinct profile of regulatory markers on neonatal microglia

(2014) Leah B Christensen et al.   Journal of Neuroinflammation

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Astrocyte activation is suppressed in both normal and injured brain by FGF signaling

(2014) W. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prions and the Potential Transmissibility of Protein Misfolding Diseases

(2013) Allison Kraus et al.   Annual Review of Microbiology

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction

(2011) S Thellung et al.   Cell Death & Disease

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies

(2009) Norbert Zilka et al.   ACTA NEUROPATHOLOGICA

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Olfactomedin Domain-Containing Proteins: Possible Mechanisms of Action and Functions in Normal Development and Pathology

(2009) Stanislav I. Tomarev et al.   MOLECULAR NEUROBIOLOGY

A systems approach to prion disease

(2009) Daehee Hwang et al.   Molecular Systems Biology