Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

Human Truncated Tau is Using a Different Mechanism from Amyloid-β to Damage the Blood-Brain Barrier

(2017) Andrej Kovac et al.   JOURNAL OF ALZHEIMERS DISEASE

IL-4-Induced Selective Clearance of Oligomeric  -Amyloid Peptide1-42 by Rat Primary Type 2 Microglia

(2014) E. Shimizu et al.   JOURNAL OF IMMUNOLOGY

Misfolded Truncated Protein   Induces Innate Immune Response via MAPK Pathway

(2011) A. Kovac et al.   JOURNAL OF IMMUNOLOGY

In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

(2011) K. Yamada et al.   JOURNAL OF NEUROSCIENCE

Corticosteroids, but not NSAIDs, are associated with less Alzheimer neuropathology

(2011) Michal Schnaider Beeri et al.   NEUROBIOLOGY OF AGING

First transgenic rat model developing progressive cortical neurofibrillary tangles

(2011) Peter Filipcik et al.   NEUROBIOLOGY OF AGING

Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

(2011) Cheng-Ning Yang et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's disease, a multifactorial disorder seeking multitherapies

(2010) Khalid Iqbal et al.   Alzheimers & Dementia

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease

(2010) Zuzana Stozicka et al.   Journal of Neuroinflammation

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

(2010) Daniel C Lee et al.   Journal of Neuroinflammation

Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques

(2010) J. A. Sonnen et al.   NEUROLOGY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

(2009) Wolfgang J. Streit et al.   ACTA NEUROPATHOLOGICA

Characteristics and consequences of muscarinic receptor activation by tau protein

(2009) Alberto Gómez-Ramos et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Accumulation of tau induced in neurites by microglial proinflammatory mediators

(2009) Philipp Gorlovoy et al.   FASEB JOURNAL

Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy

(2009) Norbert Zilka et al.   JOURNAL OF NEUROIMMUNOLOGY

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

(2008) Michelle C. Janelsins et al.   AMERICAN JOURNAL OF PATHOLOGY

Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTauP301L

(2008) Atsushi Sasaki et al.   BRAIN RESEARCH

Microglial phagocytosis is enhanced by monomeric α-synuclein, not aggregated α-synuclein: Implications for Parkinson's disease

(2008) Ji-Young Park et al.   GLIA

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

(2008) A. Gómez-Ramos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

No Effect of One-Year Treatment with Indomethacin on Alzheimer's Disease Progression: A Randomized Controlled Trial

(2008) Daniëlle de Jong et al.   PLoS One