Neuroimmunomodulatory and Neuroprotective Effects of the Flavonoid Apigenin in in vitro Models of Neuroinflammation Associated With Alzheimer’s Disease

Apigenin from Croton betulaster Müll restores the immune profile of microglia against glioma cells

(2019) Paulo L.C. Coelho et al.   PHYTOTHERAPY RESEARCH

MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology

(2019) Javier H. Jara et al.   Journal of Neuroinflammation

Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity

(2018) Cleide dos Santos Souza et al.   NEUROTOXICOLOGY

RNA Interference-Mediated Knockdown of Long-Form Phosphodiesterase-4D (PDE4D) Enzyme Reverses Amyloid-β42-Induced Memory Deficits in Mice

(2018) Cong Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammation in ALS/FTD pathogenesis

(2018) Madelyn E. McCauley et al.   ACTA NEUROPATHOLOGICA

Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism

(2018) Fawaz Alasmari et al.   Biomed Research International

In vitro models of axon regeneration

(2017) Hassan Al-Ali et al.   EXPERIMENTAL NEUROLOGY

Microglial activation in Parkinson’s disease using [18F]-FEPPA

(2017) Christine Ghadery et al.   Journal of Neuroinflammation

Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides

(2017) Li Jin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration

(2017) Ricardo Taipa et al.   Neurodegenerative Diseases

Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

(2017) Jack van Horssen et al.   NEUROSCIENCE LETTERS

Role of metabolism in neurodegenerative disorders

(2016) Claudio Procaccini et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

MFG-E8 Selectively Inhibited Aβ-Induced Microglial M1 Polarization via NF-κB and PI3K-Akt Pathways

(2016) Xiaolei Shi et al.   MOLECULAR NEUROBIOLOGY

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

(2016) Michael J. D. Daniels et al.   Nature Communications

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

(2016) Rachelle Balez et al.   Scientific Reports

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

(2015) Kevin R. Doty et al.   BRAIN RESEARCH

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Exploring the association between interleukin-1β and its interacting proteins in Alzheimer’s disease

(2015) LUSHUANG XIE et al.   Molecular Medicine Reports

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp

(2015) Andressa C. Gazola et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects – A review

(2015) Fereidoon Shahidi et al.   Journal of Functional Foods

Resveratrol as a Bioenhancer to Improve Anti-Inflammatory Activities of Apigenin

(2015) Jin-Ah Lee et al.   Nutrients

Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp

(2015) Andressa C. Gazola et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Protection of Apigenin against Kainate-Induced Excitotoxicity by Anti-oxidative Effects

(2015) Jin-Yi Han et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Activated Microglia-Induced Deficits in Excitatory Synapses Through IL-1β: Implications for Cognitive Impairment in Sepsis

(2014) Carolina A. Moraes et al.   MOLECULAR NEUROBIOLOGY

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages

(2014) Xiaoxuan Zhang et al.   PLoS One

Inflammatory components in human Alzheimer’s disease and after active amyloid-β42 immunization

(2013) Elina Zotova et al.   BRAIN

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Juliprosopine and Juliprosine from Prosopis juliflora Leaves Induce Mitochondrial Damage and Cytoplasmic Vacuolation on Cocultured Glial Cells and Neurons

(2013) Victor Diogenes A. Silva et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity

(2013) KASTHURI BAI MAGALINGAM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The flavonoid apigenin delays forgetting of passive avoidance conditioning in rats

(2013) Miroljub Popović et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Neuroprotective, Anti-Amyloidogenic and Neurotrophic Effects of Apigenin in an Alzheimer’s Disease Mouse Model

(2013) Le Zhao et al.   MOLECULES

Neuroprotective effect of apigenin in rats after contusive spinal cord injury

(2013) Feng Zhang et al.   NEUROLOGICAL SCIENCES

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis

(2012) Gholamreza Azizi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

(2012) Jonathan Vinet et al.   Journal of Neuroinflammation

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice

(2012) J H Ledo et al.   MOLECULAR PSYCHIATRY

Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke

(2012) S.S. Raza et al.   NEUROSCIENCE

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells

(2011) Kai Zhang et al.   NEUROPHARMACOLOGY

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

(2011) Andrew D. Kraft et al.   International Journal of Environmental Research and Public Health

Antioxidant properties of polyphenol-rich cocoa products industrially processed

(2010) Guillermo Schinella et al.   FOOD RESEARCH INTERNATIONAL

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

(2010) Konstantin Dirscherl et al.   Journal of Neuroinflammation

The biosynthesis of flavonoids is enhanced similarly by UV radiation and root zone salinity in L. vulgare leaves

(2010) Giovanni Agati et al.   JOURNAL OF PLANT PHYSIOLOGY

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Flavonoid intake and disability-adjusted life years due to Alzheimer’s and related dementias: a population-based study involving twenty-three developed countries

(2010) Kristopher Beking et al.   PUBLIC HEALTH NUTRITION

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING

Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction

(2007) Liqi Tong et al.   NEUROBIOLOGY OF AGING