Article
Environmental Sciences
Pratiksha Patnaik, Tabassum-Abbasi, Tasneem Abbasi, S. A. Abbasi
Summary: The study discovered a method for vermicomposting prosopis leaves, which was proven effective through a two-year experiment. This method not only utilizes the abundant prosopis leaves, but also prevents their harmful effects on the soil.
WASTE AND BIOMASS VALORIZATION
(2022)
Article
Materials Science, Multidisciplinary
S. Sowmya, K. Inbarajan, N. Ruba, Pooja Prakash, B. Janarthanan
Summary: Fresh and dried leaves of Prosopis juliflora were utilized to prepare natural dyes for use as sensitizers in Dye-Sensitized Solar Cells (DSSC). Four different dyes were studied, with the dye extracted from dried leaves using acetone as solvent showing the highest photo-conversion efficiency.
Article
Multidisciplinary Sciences
Nagaraj M. Naik, M. Krishnaveni, M. Mahadevswamy, M. Bheemanna, Udaykumar Nidoni, Vasant Kumar, K. Tejashri
Summary: This study aimed to screen bioactive compounds from Prosopis juliflora leaf supercritical fluid extract and evaluate its antimicrobial properties. Supercritical fluid extraction was more efficient than Soxhlet extraction in recovering phyto-components. Prosopis juliflora leaf supercritical fluid extract demonstrated strong antifungal and antibacterial activities.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Fahad Khan, Pratibha Pandey, Aashi Singh, Tarun Kumar Upadhyay, Shimaa Mohammed Hasnin AboElnaga, Mohammad A. A. Al-Najjar, Mohd Saeed, Danial Kahrizi
Summary: This research aimed to study the antioxidant, antiproliferative, and apoptosis-inducing properties of Prosopis juliflora methanolic leaves extract in human prostate cancer cells. The results revealed that the extract possessed significant antioxidant activity and could inhibit cancer cell proliferation and induce apoptosis. This suggests that Prosopis juliflora leaves could be a potential source of drugs for the treatment of prostate cancer.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Plant Sciences
Jasoda Choudhari, Ramakrishna Nimma, Snehal K. Nimal, Santosh Kumar Totakura Venkata, Gopal C. Kundu, Rajesh N. Gacche
Summary: The present study aimed to investigate the anti-melanoma potential of Prosopis Juliflora leaves methanol extract (PJLME) and its mechanisms of action. The results demonstrated that PJLME can inhibit the growth, migration, invasion, colony formation, and induce apoptosis in melanoma cancer cells. PJLME also exhibited anti-angiogenic potential and could suppress the Akt and Erk signaling pathways. Additionally, PJLME downregulated the expression of epithelial-mesenchymal transition (EMT) and stem cell markers. In vivo experiments further supported the inhibitory effect of PJLME on melanoma tumor growth.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Pahan
Summary: This study reveals the mechanism of interaction between tau fibrils and glia, showing that tau fibrils induce inflammation in microglia through the TLR2/MyD88 pathway. By inhibiting this pathway, inflammation and cognitive impairment can be reduced.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Integrative & Complementary Medicine
Bhimashankar Utage, Milind Patole, Punam Nagvenkar, Rajesh Gacche
Summary: This study aimed to evaluate the in vitro antileishmanial activity of Prosopis juliflora leaves extract (PJLME) against Leishmania donovani parasites, and to elucidate the mechanism of cell death. The results showed that PJLME exhibited antileishmanial activity at a low IC50 concentration and was non-toxic to mouse macrophage cells. These findings provide a reference for the development of novel drugs for the effective management of leishmaniasis.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Monaj Kumar Sarkar, Amrita Kar, Adithyan Jayaraman, Santanu Kar Mahapatra, Vellingiri Vadivel
Summary: This study investigated the anti-leukemic mechanism of phytochemical vitexin isolated from ethno-medicine used by traditional healers of West Bengal, India. Vitexin exhibited cytotoxicity by reducing mitochondrial membrane potential and causing DNA fragmentation. It was also found to inhibit cell survival proteins and promote the expression of apoptotic proteins in leukemia cells. The results suggest that vitexin could be a potential candidate for developing safe and natural drugs to treat leukemia after further preclinical and clinical trials.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Neurosciences
Liping Zhao, Shijiang Liu, Xiaobao Zhang, Juan Yang, Mao Mao, Susu Zhang, Shiqin Xu, Shanwu Feng, Xian Wang
Summary: This study investigates the role of satellite glial cell (SGC)-secreted exosomes in the communication between glia and neurons in chemotherapy-induced neuropathic pain (CINP). The results show that SGC-secreted exosomes after oxaliplatin treatment can induce mechanical hypersensitivity in DRG neurons and naive mice, possibly through miRNA cargo.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Monique Marylin Alves de Almeida, Francesca Pieropan, Tim Footz, Jorge Mauricio David, Juceni Pereira David, Victor Diogenes Amaral da Silva, Cleide dos Santos Souza, Anastassia Voronova, Arthur Morgan Butt, Silvia Lima Costa
Summary: The study showed that FAB significantly increased the proportion of MBP + / NF + axons, without affecting the overall number of oligodendroglia or axons, or the expression of oligodendroglial proteins CNPase and MBP. Additionally, FAB was found to modulate microglial responses, leading to decreased activation and increased Iba1 protein expression.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Cell Biology
Fillipe Mendes De Araujo, Annyta Fernandes Frota, Livia Bacelar de Jesus, Ticiane Caribe Macedo, Lorena Cuenca-Bermejo, Consuelo Sanchez-Rodrigo, Kariny Maria Silva Ferreira, Juciele Valeria Ribeiro de Oliveira, Maria de Fatima Dias Costa, Juan Segura-Aguilar, Silvia Lima Costa, Maria Trinidad Herrero, Victor Diogenes Amaral Silva
Summary: This study observed that aminochrome induced neuroinflammation, including microgliosis, astrogliosis, and dopaminergic neuronal loss, in an in vivo model. The findings reinforce the potential of aminochrome as a useful preclinical model for finding anti-inflammatory and neuroprotective drugs for Parkinson's disease.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Sai Zhang, Johnathan Cooper-Knock, Annika K. Weimer, Minyi Shi, Tobias Moll, Jack N. G. Marshall, Calum Harvey, Helia Ghahremani Nezhad, John Franklin, Cleide dos Santos Souza, Ke Ning, Cheng Wang, Jingjing Li, Allison A. Dilliott, Sali Farhan, Eran Elhaik, Iris Pasniceanu, Matthew R. Livesey, Chen Eitan, Eran Hornstein, Kevin P. Kenna, Jan H. Veldink, Laura Ferraiuolo, Pamela J. Shaw, Michael P. Snyder
Summary: This study developed a machine learning approach called RefMap that successfully identified 690 ALS-associated genes by integrating functional genomics with GWAS summary statistics, resulting in a 5-fold increase in recovered heritability. The study also discovered KANK1 as a new ALS gene and confirmed its role through experiments on human neurons.
Article
Neurosciences
Deivison Silva Argolo, Julita Maria Pereira Borges, Luciana dos Santos Freitas, Gizelle Alves Pina, Maria Socorro Grangeiro, Victor Diogenes Amaral da Silva, Alexandre Moraes Pinheiro, Rodrigo Souza Conceicao, Alexsandro Branco, Gilles Guillemin, Silvia Lima Costa, Maria de Fatima Dias Costa
Summary: This study evaluated the infection of rat glial cells by N. caninum and found that infection caused morphological and functional changes, increased expression of inflammatory mediators, and activation of the tryptophan catabolism pathway. The secretome from infected glial cells showed neuroprotective effects on neurons.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ravena P. do Nascimento, Livia B. de Jesus, Markley S. Oliveira-Junior, Aurea M. Almeida, Eduardo L. T. Moreira, Bruno D. Paredes, Jorge M. David, Bruno S. F. Souza, Maria de Fatima D. Costa, Arthur M. Butt, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The study found that Agathisflavone can protect injured spinal cord tissue and exhibit therapeutic effects in a rat model of acute spinal cord injury. It also promotes neurogenesis and increases the expression of neurotrophins while reducing inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Julita Maria Pereira Borges, Livia Bacelar de Jesus, Cleide dos Santos Souza, Victor Diogenes Amaral da Silva, Silvia Lima Costa, Maria de Fatima Dias Costa, Ramon Santos El-Bacha
Summary: Astrocytes play a crucial role in protecting other brain cells, particularly neurons, from damage. Microglia, a type of glial cell, can modulate astrocyte functions through the secretion of various molecules. This study found that prolonged contact with microglia before obtaining astrocyte-enriched cultures can alter the functions and morphology of astrocytes, providing protection against the cytotoxic effects of catechol.
NEUROTOXICITY RESEARCH
(2022)
Article
Neurosciences
Adriana L. Silva, Joana L. Oliveira, Ravena P. do Nascimento, Leticia O. Santos, Fillipe M. de Aranjo, Balbino L. dos Santos, Rejane C. Santana, Eduardo Luiz T. Moreira, Maria Jose M. Batatinha, Iura M. Alves, Eudes S. Velozo, Mauricio M. Victor, Adriano M. Assis, Roberto F. Almeida, Diogo O. G. de Souza, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The ingestion of MCT induces cerebrovascular lesions and toxicity to neurons in rats, accompanied by astroglial cell response and neuroinflammation in the cortex and hippocampus.
Review
Chemistry, Medicinal
Juliana Helena Castro e Silva, Jessica Teles Souza, Clarissa Schitine, Anibal de Freitas Santos Junior, Eduardo Muniz Santana Bastos, Silvia Lima Costa
Summary: This study investigates the pharmacological potential of flavonoids against neurotropic viruses. The analysis of 205 articles shows that flavonoids have a wide range of antiviral activities against viruses affecting the CNS, including influenza, hepatitis C, coronavirus, enterovirus, and arbovirus. The use of flavonoids with both neuroprotective and antiviral effects could be an alternative therapy for CNS infections.
Article
Neurosciences
Fillipe Mendes De Araujo, Annyta F. Frota, Livia B. de Jesus, Lorena Cuenca-Bermejo, Kariny Maria S. Ferreira, Cleonice Creusa Santos, Erica N. Soares, Jessica T. Souza, Flavia S. Sanches, Ana Carla S. Costa, Alana A. Farias, Maria de Fatima Dias Costa, Patricia Munoz, Jose A. Menezes-Filho, Juan Segura-Aguilar, Silvia Lima Costa, Maria Trinidad Herrero, Victor Diogenes Amaral Silva
Summary: The causes of dopaminergic neuronal loss in Parkinson's disease (PD) are not fully understood, but research suggests that a compound called Aminochrome is one of the main contributors. This study found that rutin, a naturally-occurring flavonoid, can protect against Aminochrome-induced cell death and prevent the loss of dopaminergic neurons in animal models of PD.
NEUROTOXICITY RESEARCH
(2023)
Article
Chemistry, Medicinal
Raquel B. M. de Almeida, Deyse B. B. Barbosa, Mayra R. R. do Bomfim, Jessika A. O. Amparo, Bruno S. S. Andrade, Silvia L. L. Costa, Joaquin M. Campos, Jorddy N. Cruz, Cleydson B. R. Santos, Franco H. A. Leite, Mariana B. B. Botura
Summary: The compound ZINC390718 was found to exhibit inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and showed low cytotoxicity in vitro. Molecular dynamics (MD) simulation revealed that ZINC390718 interacted with the catalytic residue sites of both enzymes. These findings suggest that ZINC390718 could be a potential chemotype for the development of new dual cholinesterase inhibitors.
Review
Neurosciences
Lucas Matheus Goncalves de Oliveira, Rodrigo Barreto Carreira, Juciele Valeria Ribeiro de Oliveira, Ravena Pereira do Nascimento, Cleide dos Santos Souza, Emiliano Trias, Victor Diogenes Amaral da Silva, Silvia Lima Costa
Summary: Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motor neuron degeneration. Current treatments are symptom-based and do not cure the disease. Glia, neuroinflammation, oxidative stress, and glutamate excitotoxicity have been implicated in the molecular mechanisms of ALS. Plant-derived compounds with neuroprotective effects and glial cell response have shown promise as potential therapeutic strategies for ALS.
NEUROTOXICITY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Balbino Lino dos Santos, Cleonice Creusa dos Santos, Janaina R. P. Soares, Karina C. C. da Silva, Juciele Valeria R. de Oliveira, Gabriele S. S. Pereira, Fillipe M. M. de Araujo, Maria de Fatima D. Costa, Jorge Mauricio David, Victor Diogenes A. da Silva, Arthur Morgan Butt, Silvia Lima Costa
Summary: Agathisflavone from Cenostigma pyramidale has shown neuroprotective effects in in vitro models of glutamate-induced excitotoxicity and inflammatory damage. This study investigated the potential role of agathisflavone in regulating microglia and its neuroprotective effects. The results demonstrated that agathisflavone can inhibit inflammation in microglia and reduce the expression of inflammatory factors, thereby exerting anti-inflammatory and neuroprotective effects.
Article
Integrative & Complementary Medicine
Rafael Short Ferreira, Paulo Roberto Ribeiro, Juliana Helena Castro e Silva, Juliana Bender Hoppe, Monique Marylin Alves de Almeida, Beatriz Correia de Lima Ferreira, Gustavo Borges Andrade, Suzana Braga de Souza, Luzimar Gonzaga Ferdandez, Maria de Fatima Dias Costa, Christianne Gazzana Salbego, Andrea Domenico Rivera, Aline Longoni, Adriano Martimbianco de Assis, Francesca Pieropan, Jose Claudio Fonseca Moreira, Silvia Lima Costa, Arthur Morgan Butt, Victor Diogenes Amaral da Silva
Summary: This study demonstrates that the compound EDAC extracted from Amburana cearensis seeds exhibits cytoprotective activity against ischemia and glutamate excitotoxicity in hippocampal brain slices. EDAC increases the expression of glutamate transporters and glutamine synthetase, modulating astrocyte responses and their glutamate homeostatic mechanisms.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)