MFG-E8 Selectively Inhibited Aβ-Induced Microglial M1 Polarization via NF-κB and PI3K-Akt Pathways

NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury

(2016) Alok Kumar et al.   BRAIN BEHAVIOR AND IMMUNITY

scAAV9-VEGF prolongs the survival of transgenic ALS mice by promoting activation of M2 microglia and the PI3K/Akt pathway

(2016) Ying Wang et al.   BRAIN RESEARCH

M2 Macrophage Transplantation Ameliorates Cognitive Dysfunction in Amyloid-β-Treated Rats Through Regulation of Microglial Polarization

(2016) Dan Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

(2016) Mousumi Ghosh et al.   Journal of Neuroinflammation

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dual polarization of microglia isolated from mixed glial cell cultures

(2015) Lili Ju et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Curcumin inhibits Aβ-induced microglial inflammatory responses in vitro: Involvement of ERK1/2 and p38 signaling pathways

(2015) Xiaolei Shi et al.   NEUROSCIENCE LETTERS

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

(2015) Douglas G. Walker et al.   Alzheimers Research & Therapy

Targeting microglia for the treatment of Alzheimer’s disease

(2014) Patrick L McGeer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Redox regulation of NF-κB p50 and M1 polarization in microglia

(2014) Thomas Taetzsch et al.   GLIA

Lactadherin/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid β

(2013) Urte Neniskyte et al.   JOURNAL OF NEUROCHEMISTRY

Essential Role of MFG-E8 for Phagocytic Properties of Microglial Cells

(2013) Yong Liu et al.   PLoS One

Comparison of polarization properties of human adult microglia and blood-derived macrophages

(2012) Bryce A. Durafourt et al.   GLIA

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice

(2012) K. Kawahara et al.   NEUROSCIENCE

MFG-E8 Released by Apoptotic Endothelial Cells Triggers Anti-Inflammatory Macrophage Reprogramming

(2012) Marie-Joëlle Brissette et al.   PLoS One

Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation

(2011) Monowar Aziz et al.   APOPTOSIS

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

“Tissue-repairing” blood-derived macrophages are essential for healing of the injured spinal cord: From skin-activated macrophages to infiltrating blood-derived cells?

(2010) Michal Schwartz   BRAIN BEHAVIOR AND IMMUNITY

A fibril-specific, conformation-dependent antibody recognizes a subset of Aβ plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain

(2009) Floyd Sarsoza et al.   ACTA NEUROPATHOLOGICA

SED1/MFG-E8: A Bi-Motif protein that orchestrates diverse cellular interactions

(2009) Adam Raymond et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

MFG-E8 Regulates Microglial Phagocytosis of Apoptotic Neurons

(2008) Abby D. Fuller et al.   Journal of Neuroimmune Pharmacology