Endothelial Progenitor Cell‐Derived Extracellular Vesicles: A Novel Candidate for Regenerative Medicine and Disease Treatment

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

MicroRNA-126 protects against vascular injury by promoting homing and maintaining stemness of late outgrowth endothelial progenitor cells

(2020) Chong Zhe Pei et al.   Stem Cell Research & Therapy

Exosomes secreted by endothelial progenitor cells accelerate bone regeneration during distraction osteogenesis by stimulating angiogenesis

(2019) Yachao Jia et al.   Stem Cell Research & Therapy

Putative endothelial progenitor cells do not promote vascular repair but attenuate pericyte–myofibroblast transition in UUO-induced renal fibrosis

(2019) Juan Yang et al.   Stem Cell Research & Therapy

Polyethylene glycol improves current methods for circulating extracellular vesicle-derived DNA isolation

(2019) N. García-Romero et al.   Journal of Translational Medicine

A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche

(2019) Lijian Shao et al.   HAEMATOLOGICA

Retinoic acid signaling in vascular development

(2019) Brad Pawlikowski et al.   GENESIS

Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction

(2019) Wenqi Sun et al.   DRUG DELIVERY

Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery

(2019) Sagar Rayamajhi et al.   Acta Biomaterialia

Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury

(2019) Yuan Gui et al.   CELL DEATH AND DIFFERENTIATION

Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus

(2019) Robert Spaull et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

EPC ‐derived exosomes promote osteoclastogenesis through Lnc RNA ‐ MALAT 1

(2019) Yigong Cui et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanisms associated with biogenesis of exosomes in cancer

(2019) Kathleen M. McAndrews et al.   Molecular Cancer

BMPR2‐expressing bone marrow‐derived endothelial‐like progenitor cells alleviate pulmonary arterial hypertension in vivo

(2019) Rebecca L. Harper et al.   RESPIROLOGY

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

(2019) Sangiliyandi Gurunathan et al.   Cells

Advances in exosome isolation methods and their applications in proteomic analysis of biological samples

(2019) Rui Hou et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Biocompatibility, in Vitro Antiproliferative, and in Silico EGFR/VEGFR2 Studies of Heteroleptic Metal(II) Complexes of Thiosemicarbazones and Naproxen

(2019) Sundaram Bharathi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Advances in exosomes technology

(2019) Bo-Yie Chen et al.   CLINICA CHIMICA ACTA

Endothelial progenitor cell-derived exosomes facilitate vascular endothelial cell repair through shuttling miR-21-5p to modulate Thrombospondin-1 expression

(2019) Hui Hu et al.   CLINICAL SCIENCE

Building Blood Vessels—One Rho GTPase at a Time

(2019) Haley Rose Barlow et al.   Cells

Exosomes secreted by endothelial progenitor cells improve the bioactivity of pulmonary microvascular endothelial cells exposed to hyperoxia in vitro

(2019) Xiaomei Zhang et al.   Annals of Translational Medicine

Exosomes derived from induced vascular progenitor cells promote angiogenesis in vitro and in an in vivo rat hindlimb ischemia model

(2019) Takerra K. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction: Implications for Statin Treatment in HIV Patients

(2019) Sarvesh Chelvanambi et al.   CIRCULATION RESEARCH

Extrarenal Immune-Mediated Disorders Linked with Acute Poststreptococcal Glomerulonephritis: a Systematic Review

(2019) Elena A. Bertola et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Effects of Sitagliptin on the Coronary Flow Reserve, Circulating Endothelial Progenitor Cells and Stromal Cell-derived Factor-1alpha

(2019) Tetsuji Morishita et al.   INTERNAL MEDICINE

Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: just What It Takes to Make a Blood Vessel

(2019) Moccia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of cardiac progenitor cell‐derived exosome‐mediated microRNA‐210 in cardiovascular disease

(2019) Lirong Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

miR-21 induces endothelial progenitor cells proliferation and angiogenesis via targeting FASLG and is a potential prognostic marker in deep venous thrombosis

(2019) Xiaolong Du et al.   Journal of Translational Medicine

YBX-1 mediated sorting of miR-133 into hypoxia/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT

(2019) Fengxia Lin et al.   Stem Cell Research & Therapy

High-Mobility Group Box 1 (HMGB1) Induces Migration of Endothelial Progenitor Cell via Receptor for Advanced Glycation End-Products (RAGE)-Dependent PI3K/Akt/eNOS Signaling Pathway

(2019) Yulong Zhang et al.   MEDICAL SCIENCE MONITOR

Ultrastructure of intestinal mucosa in diarrhea-predominant irritable bowel syndrome

(2019) D-Y Zhao et al.   Physiology International

Biomarkers of Acute Lung Injury The Individualized Approach: for Phenotyping, Risk Stratification and Treatment Surveillance

(2019) Daniel D. Murray et al.   Journal of Clinical Medicine

Enhancement of cardiac lymphangiogenesis by transplantation of CD34+VEGFR-3+ endothelial progenitor cells and sustained release of VEGF-C

(2019) Hai-feng Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

Exosome-delivered syndecan-1 rescues acute lung injury via a FAK/p190RhoGAP/RhoA/ROCK/NF-κB signaling axis and glycocalyx enhancement

(2019) Chuankai Zhang et al.   EXPERIMENTAL CELL RESEARCH

Vitamin D (1,25-(OH)2D3) regulates the gene expression through competing endogenous RNAs networks in high glucose-treated endothelial progenitor cells

(2019) Ping Yu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Isolation and Profiling of Circulating Tumor‐Associated Exosomes Using Extracellular Vesicular Lipid–Protein Binding Affinity Based Microfluidic Device

(2019) Yoon‐Tae Kang et al.   Small

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

(2019) Tuying Yong et al.   Nature Communications

Extracellular vesicles from endothelial progenitor cells prevent steroid-induced osteoporosis by suppressing the ferroptotic pathway in mouse osteoblasts based on bioinformatics evidence

(2019) Jinsen Lu et al.   Scientific Reports

MicroRNA-326-5p enhances therapeutic potential of endothelial progenitor cells for myocardial infarction

(2019) Xiaoting Li et al.   Stem Cell Research & Therapy

Interleukin-10 Deficiency Alters Endothelial Progenitor Cell–Derived Exosome Reparative Effect on Myocardial Repair via Integrin-Linked Kinase Enrichment

(2019) Yujia Yue et al.   CIRCULATION RESEARCH

Mesoderm specification and diversification: from single cells to emergent tissues

(2019) Elisabetta Ferretti et al.   CURRENT OPINION IN CELL BIOLOGY

Exosomal lncRNAs and cancer: connecting the missing links

(2018) Hojjat Naderi-Meshkin et al.   BIOINFORMATICS

Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction

(2018) Carol W Chen et al.   CARDIOVASCULAR RESEARCH

Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function

(2018) Xiaotang Ma et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Exosomes derived from endothelial progenitor cells ameliorate acute lung injury by transferring miR-126

(2018) Xu Wu et al.   EXPERIMENTAL CELL RESEARCH

Endothelial colony-forming cell-derived exosomes restore blood-brain barrier continuity in mice subjected to traumatic brain injury

(2018) Weiwei Gao et al.   EXPERIMENTAL NEUROLOGY

ACE2-EPC-EXs protect ageing ECs against hypoxia/reoxygenation-induced injury through the miR-18a/Nox2/ROS pathway

(2018) Cheng Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomes of endothelial progenitor cells inhibit neointima formation after carotid artery injury

(2018) Jie Kong et al.   JOURNAL OF SURGICAL RESEARCH

Endothelial progenitor cells improve the therapeutic effect of mesenchymal stem cell sheets on irradiated bone defect repair in a rat model

(2018) Huan Liu et al.   Journal of Translational Medicine

Endothelial Progenitor Cells and Kidney Diseases

(2018) Abdullah Ozkok et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Dexmedetomidine attenuates renal fibrosis via α2-adrenergic receptor-dependent inhibition of cellular senescence after renal ischemia/reperfusion

(2018) Qijian Li et al.   LIFE SCIENCES

Moderate Exercise Enhances Endothelial Progenitor Cell Exosomes Release and Function

(2018) Chunlian Ma et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The journey of islet cell transplantation and future development

(2018) Anissa Gamble et al.   Islets

Extracellular Vesicle Subtypes Released From Activated or Apoptotic T-Lymphocytes Carry a Specific and Stimulus-Dependent Protein Cargo

(2018) Christine Tucher et al.   Frontiers in Immunology

On the origin of the human germline

(2018) Toshihiro Kobayashi et al.   DEVELOPMENT

Induction of HIF-1α by HIV-1 Infection in CD4+ T Cells Promotes Viral Replication and Drives Extracellular Vesicle-Mediated Inflammation

(2018) Gabriel Duette et al.   mBio

Distinct Anti-Fibrotic Effects of Exosomes Derived from Endothelial Colony-Forming Cells Cultured Under Normoxia and Hypoxia

(2018) WenHao Liu et al.   MEDICAL SCIENCE MONITOR

Endothelial Progenitor Cells at the Interface of Chronic Kidney Disease: From Biology to Therapeutic Advancement

(2018) Giuseppe Coppolino et al.   CURRENT MEDICINAL CHEMISTRY

Bone marrow derived endothelial progenitor cells retain their phenotype and functions after a limited number of culture passages and cryopreservation

(2018) Xianghui Gong et al.   CYTOTECHNOLOGY

Comparison of exosomes purified via ultracentrifugation (UC) and Total Exosome Isolation (TEI) reagent from the serum of Marek’s disease virus (MDV)-vaccinated and tumor-bearing chickens

(2018) Sabari Nath Neerukonda et al.   JOURNAL OF VIROLOGICAL METHODS

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Intrinsic Vascular Repair by Endothelial Progenitor Cells in Acute Coronary Syndromes: an Update Overview

(2018) Vânia Leal et al.   Stem Cell Reviews and Reports

Exosome: a novel mediator in drug resistance of cancer cells

(2018) He-da Zhang et al.   Epigenomics

Receptor-Ligand Interaction Mediates Targeting of Endothelial Colony Forming Cell-derived Exosomes to the Kidney after Ischemic Injury

(2018) Jose L. Viñas et al.   Scientific Reports

Insights into Endothelial Progenitor Cells: Origin, Classification, Potentials, and Prospects

(2018) H. Chopra et al.   Stem Cells International

Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum

(2017) Yue-Ting Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MicroRNA-containing extracellular vesicles released from endothelial colony-forming cells modulate angiogenesis during ischaemic retinopathy

(2017) Margaret Dellett et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Human vascular progenitor cells derived from renal arteries are endothelial-like and assist in the repair of injured renal capillary networks

(2017) Paul Pang et al.   KIDNEY INTERNATIONAL

Endothelial progenitor cell-derived extracellular vesicle-meditated cell-to-cell communication regulates the proliferation and osteoblastic differentiation of bone mesenchymal stromal cells

(2017) Yunhao Qin et al.   Molecular Medicine Reports

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

(2017) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients

(2017) Ting-Yu Chang et al.   PLoS One

Endothelial Progenitor Cells’ Classification and Application in Neurological Diseases

(2017) Jing-jing Yuan et al.   Tissue Engineering and Regenerative Medicine

Interleukin-10 Deficiency Impairs Reparative Properties of Bone Marrow-Derived Endothelial Progenitor Cell Exosomes

(2017) Yujia Yue et al.   TISSUE ENGINEERING PART A

Human Periodontal Ligament- and Gingiva-derived Mesenchymal Stem Cells Promote Nerve Regeneration When Encapsulated in Alginate/Hyaluronic Acid 3D Scaffold

(2017) Sahar Ansari et al.   Advanced Healthcare Materials

Stem Cell-Derived Extracellular Vesicles as a Novel Potential Therapeutic Tool for Tissue Repair

(2017) Bi Chen et al.   Stem Cells Translational Medicine

Endothelial Progenitor Cells’ Classification and Application in Neurological Diseases

(2017) Jing-jing Yuan et al.   Tissue Engineering and Regenerative Medicine

Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research

(2017) Glenn Vergauwen et al.   Scientific Reports

Microvesicles derived from Alde-Low EPCs support the wound healing capacity of AT-MSCs

(2016) Tran Cam Tu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exosomes derived from endothelial progenitor cells attenuate vascular repair and accelerate reendothelialization by enhancing endothelial function

(2016) Xiaocong Li et al.   CYTOTHERAPY

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

(2016) Yu Bo Yang Sun et al.   DIFFERENTIATION

Exosomes Derived from Human Endothelial Progenitor Cells Accelerate Cutaneous Wound Healing by Promoting Angiogenesis Through Erk1/2 Signaling

(2016) Jieyuan Zhang et al.   International Journal of Biological Sciences

Purification of HIV-1 gag virus-like particles and separation of other extracellular particles

(2016) Petra Steppert et al.   JOURNAL OF CHROMATOGRAPHY A

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Human endothelial progenitor cells-derived exosomes accelerate cutaneous wound healing in diabetic rats by promoting endothelial function

(2016) Xiaocong Li et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

(2016) Debayon Paul et al.   Journal of Neuroinflammation

Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers

(2016) Sean W. Harshman et al.   Journal of Proteomics

Transfer of microRNA-486-5p from human endothelial colony forming cell–derived exosomes reduces ischemic kidney injury

(2016) Jose L. Viñas et al.   KIDNEY INTERNATIONAL

Exosomes from Cardiomyocyte Progenitor Cells and Mesenchymal Stem Cells Stimulate Angiogenesis Via EMMPRIN

(2016) Krijn R. Vrijsen et al.   Advanced Healthcare Materials

Human Endothelial Colony-Forming Cells Protect against Acute Kidney Injury

(2015) Dylan Burger et al.   AMERICAN JOURNAL OF PATHOLOGY

Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation

(2015) Xiaomei Teng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

Mechanisms of RNA loading into exosomes

(2015) Teresa Janas et al.   FEBS LETTERS

Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

(2015) Yingjie Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

(2015) Natasa Zarovni et al.   METHODS

Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct

(2015) Rong Xu et al.   METHODS

Engineering Stem Cells for Biomedical Applications

(2015) Perry T. Yin et al.   Advanced Healthcare Materials

MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma

(2015) Maria Eldh et al.   BMC CANCER

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Endothelial progenitor cell-derived extracellular vesicles protect from complement-mediated mesangial injury in experimental anti-Thy1.1 glomerulonephritis

(2014) Vincenzo Cantaluppi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

EPC-Derived Microvesicles Protect Cardiomyocytes from Ang II-Induced Hypertrophy and Apoptosis

(2014) Shenhong Gu et al.   PLoS One

CD34/CD133 enriched bone marrow progenitor cells promote neovascularization of tissue engineered constructs in vivo

(2014) Marietta Herrmann et al.   Stem Cell Research

PPAR-γ agonist pioglitazone prevents apoptosis of endothelial progenitor cells from rat bone marrow

(2013) Hui-Feng Zhang et al.   CELL BIOLOGY INTERNATIONAL

Therapeutics targeting angiogenesis: Genetics and epigenetics, extracellular miRNAs and signaling networks (Review)

(2013) MASARU KATOH   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

(2013) Marina Colombo et al.   JOURNAL OF CELL SCIENCE

Exosomes derived from Rab27a-overexpressing tumor cells elicit efficient induction of antitumor immunity

(2013) WENHAI LI et al.   Molecular Medicine Reports

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Endothelial Progenitor Cells in Postnatal Vasculogenesis: Implications for Therapeutic Neovascularization and Wound Healing

(2013) Swathi Balaji et al.   Advances in Wound Care

Microvesicles Derived from Endothelial Progenitor Cells Enhance Neoangiogenesis of Human Pancreatic Islets

(2012) Vincenzo Cantaluppi et al.   CELL TRANSPLANTATION

Endothelial progenitor cells: the promise of cell-based therapies for acute lung injury

(2012) Mei Mao et al.   INFLAMMATION RESEARCH

Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia–reperfusion injury by microRNA-dependent reprogramming of resident renal cells

(2012) Vincenzo Cantaluppi et al.   KIDNEY INTERNATIONAL

Paracrine Proangiopoietic Effects of Human Umbilical Cord Blood-Derived Purified CD133+ Cells—Implications for Stem Cell Therapies in Regenerative Medicine

(2012) Janina Ratajczak et al.   STEM CELLS AND DEVELOPMENT

Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage

(2011) Ji Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Haemogenic endothelium in infantile haemangioma

(2010) T. Itinteang et al.   JOURNAL OF CLINICAL PATHOLOGY

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man

(2009) Dong Yeon Lee et al.   BONE

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP

Circulating endothelial cells in oncology: pitfalls and promises

(2008) M H Strijbos et al.   BRITISH JOURNAL OF CANCER

Endothelial cells from cord blood CD133+CD34+progenitors share phenotypic, functional and gene expression profile similarities with lymphatics

(2008) Van Anh Nguyen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE