HIV-Nef Protein Transfer to Endothelial Cells Requires Rac1 Activation and Leads to Endothelial Dysfunction: Implications for Statin Treatment in HIV Patients

Association of Human Immunodeficiency Virus Infection and Risk of Peripheral Artery Disease

(2018) Joshua A. Beckman et al.   CIRCULATION

Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA

(2018) Jana Ferdin et al.   PLoS One

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses

(2018) Ryan P. McNamara et al.   mBio

HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles

(2018) J.-H. Lee et al.   EBioMedicine

Vascular endothelial dysfunction in the wake of HIV and ART

(2018) Clara Marincowitz et al.   FEBS Journal

HIV-1 Nef Disrupts CD4+ T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface

(2018) Miguel Lamas-Murua et al.   JOURNAL OF IMMUNOLOGY

Endothelial Colony Forming Cell Function Is Reduced in HIV

(2018) Samir K Gupta et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-Nef Protein Persists in the Lungs of Aviremic HIV Patients and Induces Endothelial Cell Death

(2018) Sarvesh Chelvanambi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy

(2017) Manish K. Gupta et al.   Scientific Reports

Pitavastatin versus pravastatin in adults with HIV-1 infection and dyslipidaemia (INTREPID): 12 week and 52 week results of a phase 4, multicentre, randomised, double-blind, superiority trial

(2017) Judith A Aberg et al.   Lancet HIV

Effect of Advanced HIV Infection on the Respiratory Microbiome

(2016) Homer L. Twigg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Endogenous Transmembrane TNF-Alpha Protects Against Premature Senescence in Endothelial Colony Forming CellsNovelty and Significance

(2016) Linden A. Green et al.   CIRCULATION RESEARCH

Role of T‐Cell Dysfunction, Inflammation, and Coagulation in Microvascular Disease in HIV

(2016) Arjun Sinha et al.   Journal of the American Heart Association

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection

(2016) Jung-Hyun Lee et al.   EBioMedicine

Atorvastatin treatment improves endothelial function through endothelial progenitor cells mobilization in ischemic heart failure patients

(2015) Evangelos Oikonomou et al.   ATHEROSCLEROSIS

Pharmacokinetic Drug–Drug Interaction Study Between Raltegravir and Atorvastatin 20 mg in Healthy Volunteers

(2015) Maren Blonk et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HIV Infection, Cardiovascular Disease Risk Factor Profile, and Risk for Acute Myocardial Infarction

(2015) Anne-Lise Paisible et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Krüppel-like Factor 2 and Endothelial Dysfunction

(2015) Soumya Panigrahi et al.   JOURNAL OF INFECTIOUS DISEASES

Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial

(2015) Janet Lo et al.   Lancet HIV

Lack of Pharmacokinetic Interactions Between Pitavastatin and Efavirenz or Darunavir/Ritonavir

(2014) Carlos D. Malvestutto et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4+ T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism

(2014) C. Arenaccio et al.   JOURNAL OF VIROLOGY

DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway

(2014) H-H Chen et al.   ONCOGENE

Transfer of Intracellular HIV Nef to Endothelium Causes Endothelial Dysfunction

(2014) Ting Wang et al.   PLoS One

Inhibition of Rho and Rac Geranylgeranylation by Atorvastatin Is Critical for Preservation of Endothelial Junction Integrity

(2013) Hongbing Xiao et al.   PLoS One

Mortality in well controlled HIV in the continuous antiretroviral therapy arms of the SMART and ESPRIT trials compared with the general population

(2012) Alison J. Rodger et al.   AIDS

Endothelial Dysfunction, Arterial Stiffening, and Intima-Media Thickening in Large Arteries from HIV-1 Transgenic Mice

(2012) Laura Hansen et al.   ANNALS OF BIOMEDICAL ENGINEERING

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Role of ERK1/2 Signaling Pathway in Nef Protein Upregulation of the Expression of the Intercellular Adhesion Molecule 1 in Endothelial Cells

(2010) Yang Fan et al.   ANGIOLOGY

HIV type 1 infection, and not short-term HAART, induces endothelial dysfunction

(2009) Daniela Francisci et al.   AIDS

HIV-1 Nef induces p47phoxphosphorylation leading to a rapid superoxide anion release from the U937 human monoblastic cell line

(2009) Eleonora Olivetta et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HIV Nef Protein Causes Endothelial Dysfunction in Porcine Pulmonary Arteries and Human Pulmonary Artery Endothelial Cells

(2009) Patrick Duffy et al.   JOURNAL OF SURGICAL RESEARCH

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Epidemiological Evidence for Cardiovascular Disease in HIV-Infected Patients and Relationship to Highly Active Antiretroviral Therapy

(2008) Judith S. Currier et al.   CIRCULATION

Aortic Stiffness in Untreated Adult Patients With Human Immunodeficiency Virus Infection

(2008) Giuseppe Schillaci et al.   HYPERTENSION

Biphasic decay kinetics suggest progressive slowing in turnover of latently HIV-1 infected cells during antiretroviral therapy

(2008) Marek Fischer et al.   Retrovirology