MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium tuberculosis through Targeting LNX1 via NEK6 Accumulation to Promote Anti-Apoptotic STAT3 Signaling

STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia

(2019) Qinjie Weng et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-325-3p protects the heart after myocardial infarction by inhibiting RIPK3 and programmed necrosis in mice

(2019) Dong-Ying Zhang et al.   BMC MOLECULAR BIOLOGY

PLK 4 deubiquitination by Spata2‐CYLD suppresses NEK7‐mediated NLRP3 inflammasome activation at the centrosome

(2019) Xiao‐Dong Yang et al.   EMBO JOURNAL

miRNAs in immune responses to Mycobacterium tuberculosis infection

(2018) Tianshu Yang et al.   CANCER LETTERS

STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion

(2018) Daniel Kogan et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of LNX1:Ubc13 ~ Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1

(2018) Digant Nayak et al.   JOURNAL OF MOLECULAR BIOLOGY

Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells

(2018) Marilena P. Etna et al.   PLoS Pathogens

Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release

(2018) Manjeet Mukherjee et al.   Science Signaling

STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma

(2018) Jonathan S. Fletcher et al.   ONCOGENE

MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy

(2018) Feng Liu et al.   Nature Communications

Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease

(2018) Mazen Kurdi et al.   Frontiers in Immunology

Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages

(2017) C.J. Cambier et al.   IMMUNITY

Differential control of Toll-like receptor 4–induced interleukin-10 induction in macrophages and B cells reveals a role for p90 ribosomal S6 kinases

(2017) Ruhcha V. Sutavani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of Mycobacterial Lipids by Immune Receptors

(2017) Eri Ishikawa et al.   TRENDS IN IMMUNOLOGY

Immune regulation of miR-30 on the Mycobacterium tuberculosis-induced TLR/MyD88 signaling pathway in THP-1 cells

(2017) Yuqing Wu et al.   Experimental and Therapeutic Medicine

Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

(2017) Nacho Aguilo et al.   Nature Communications

Perturbed microRNA Expression by Mycobacterium tuberculosis Promotes Macrophage Polarization Leading to Pro-survival Foam Cell

(2017) Pankaj Kumar Ahluwalia et al.   Frontiers in Immunology

Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6

(2016) Atish D. Choudhury et al.   CANCER RESEARCH

Types of Ubiquitin Ligases

(2016) Francesca Ester Morreale et al.   CELL

miRNA profiling of human naive CD4 T cells links miR‐34c‐5p to cell activation and HIV replication

(2016) Andreia J Amaral et al.   EMBO JOURNAL

Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

(2016) Marios G Koliopoulos et al.   EMBO JOURNAL

MiR-155–regulated molecular network orchestrates cell fate in the innate and adaptive immune response toMycobacterium tuberculosis

(2016) Alissa C. Rothchild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-mediated immune activation and infiltration

(2016) Xuefeng Li et al.   Nature Microbiology

MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway

(2015) Manish Kumar et al.   Cell Host & Microbe

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression

(2015) Laura O’Regan et al.   JOURNAL OF CELL BIOLOGY

The balance between protective and pathogenic immune responses in the TB-infected lung

(2015) Ian M Orme et al.   NATURE IMMUNOLOGY

Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system

(2015) Jing Wang et al.   NATURE IMMUNOLOGY

TALE nickase-mediatedSP110knockin endows cattle with increased resistance to tuberculosis

(2015) Haibo Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Functions of MicroRNAs: mRNA Decay and Translational Repression

(2015) Hiro-oki Iwakawa et al.   TRENDS IN CELL BIOLOGY

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

(2014) Tara E Sutherland et al.   NATURE IMMUNOLOGY

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment

(2013) Hye Jin Jee et al.   CANCER LETTERS

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Role of NEK6 in Tumor Promoter-induced Transformation in JB6 C141 Mouse Skin Epidermal Cells

(2010) Young Jin Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cell (DC)-Specific Targeting Reveals Stat3 as a Negative Regulator of DC Function

(2010) Jessica A. Melillo et al.   JOURNAL OF IMMUNOLOGY