Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis

Novel approaches to tuberculosis vaccine development

(2017) Stefan H.E. Kaufmann et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

(2017) Matthias I. Gröschel et al.   Cell Reports

Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study

(2017) Jason R Andrews et al.   Lancet Respiratory Medicine

EspC forms a filamentous structure in the cell envelope ofMycobacterium tuberculosisand impacts ESX-1 secretion

(2016) Ye Lou et al.   MOLECULAR MICROBIOLOGY

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

(2016) David Stucki et al.   NATURE GENETICS

MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice

(2016) Nacho Aguilo et al.   TUBERCULOSIS

Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype

(2016) Clare M. Smith et al.   mBio

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans

(2016) Cecilia S. Lindestam Arlehamn et al.   PLoS Pathogens

Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial

(2015) François Spertini et al.   Lancet Respiratory Medicine

A Specific Polymorphism in Mycobacterium tuberculosis H37Rv Causes Differential ESAT-6 Expression and Identifies WhiB6 as a Novel ESX-1 Component

(2014) Luis Solans et al.   INFECTION AND IMMUNITY

Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator

(2014) J. Gonzalo-Asensio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG)

(2014) Richard Copin et al.   VACCINE

Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice

(2014) Luis Solans et al.   VACCINE

The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis

(2014) Luis Solans et al.   PLoS Pathogens

Systems infection biology: a compartmentalized immune network of pig spleen challenged with Haemophilus parasuis

(2013) Ming Zhao et al.   BMC GENOMICS

Recent developments in tuberculosis vaccines

(2013) Dessislava Marinova et al.   Expert Review of Vaccines

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

(2013) Philip Supply et al.   NATURE GENETICS

Genome Sequencing and Analysis of BCG Vaccine Strains

(2013) Wen Zhang et al.   PLoS One

Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials

(2013) Ainhoa Arbues et al.   VACCINE

Risk of Progression to Active Tuberculosis Following Reinfection With Mycobacterium tuberculosis

(2012) Jason R. Andrews et al.   CLINICAL INFECTIOUS DISEASES

MprAB Regulates the espA Operon in Mycobacterium tuberculosis and Modulates ESX-1 Function and Host Cytokine Response

(2012) X. Pang et al.   JOURNAL OF BACTERIOLOGY

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

A multistage tuberculosis vaccine that confers efficient protection before and after exposure

(2011) Claus Aagaard et al.   NATURE MEDICINE

Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection

(2011) K. A. Millington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suboptimal Activation of Antigen-Specific CD4+ Effector Cells Enables Persistence of M. tuberculosis In Vivo

(2011) Tyler D. Bold et al.   PLoS Pathogens

Secreted Immunodominant Mycobacterium tuberculosis Antigens Are Processed by the Cytosolic Pathway

(2010) J. E. Grotzke et al.   JOURNAL OF IMMUNOLOGY

MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

(2009) Frank A. W. Verreck et al.   PLoS One

Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

(2008) Wafa Frigui et al.   PLoS Pathogens