Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease

CD1d-dependent natural killer T cells attenuate angiotensin II-induced cardiac remodelling via IL-10 signalling in mice

(2018) Hong-Xia Wang et al.   CARDIOVASCULAR RESEARCH

IL-10-STAT3-Galectin-3 Axis is Essential for Osteopontin-Producing Reparative Macrophage Polarization After Myocardial Infarction

(2018) Kohsuke Shirakawa et al.   CIRCULATION

Sympathetic nerve blocks promote anti-inflammatory response by activating the JAK2-STAT3–mediated signaling cascade in rat myocarditis models: A novel mechanism with clinical implications

(2018) Hyelim Park et al.   HEART RHYTHM

Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway

(2018) Lingyan Yuan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy

(2018) Luping Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

(2018) Yonggang Ma et al.   Translational Research

Regulatory Role of CD4+ T Cells in Myocarditis

(2018) Daria Vdovenko et al.   Journal of Immunology Research

βIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload

(2018) Sathya D. Unudurthi et al.   JOURNAL OF CLINICAL INVESTIGATION

Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts

(2017) Tsung-Ming Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice

(2017) Jing Ye et al.   MEDIATORS OF INFLAMMATION

Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3

(2017) Hengxun Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Interleukin 22 Promotes Blood Pressure Elevation and Endothelial Dysfunction in Angiotensin II–Treated Mice

(2017) Jing Ye et al.   Journal of the American Heart Association

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

(2017) Jeremy A. Meier et al.   Science Signaling

Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6

(2017) Sei-ichiro Ohkura et al.   PLoS One

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice

(2016) Ameh Omede et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway

(2016) Sheng-an Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Deletion of Interleukin-6 Attenuates Pressure Overload-Induced Left Ventricular Hypertrophy and DysfunctionNovelty and Significance

(2016) Lin Zhao et al.   CIRCULATION RESEARCH

Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy

(2016) Britta Stapel et al.   EUROPEAN HEART JOURNAL

Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy

(2016) Ritwik Datta et al.   MOLECULAR AND CELLULAR BIOLOGY

Cardiac STAT3 Deficiency Impairs Contractility and Metabolic Homeostasis in Hypertension

(2016) Raffaele Altara et al.   Frontiers in Pharmacology

Cardiac-specific ablation of the STAT3 gene in the subacute phase of myocardial infarction exacerbated cardiac remodeling

(2015) Daichi Enomoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Critical Roles of STAT3 in β-Adrenergic Functions in the HeartCLINICAL PERSPECTIVE

(2015) Wenjun Zhang et al.   CIRCULATION

Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine

(2015) Raffaele Altara et al.   HEART FAILURE REVIEWS

Deletion of interleukin-6 prevents cardiac inflammation, fibrosis and dysfunction without affecting blood pressure in angiotensin II-high salt-induced hypertension

(2015) Germán E. González et al.   JOURNAL OF HYPERTENSION

Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation

(2015) Carlos A. Báez-Pagán et al.   Journal of Neuroimmune Pharmacology

Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart

(2015) Holger Lörchner et al.   NATURE MEDICINE

Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules

(2015) Takanobu Nagata et al.   PLoS One

Opposing roles of Akt and STAT3 in the protection of the maternal heart from peripartum stress

(2014) Melanie Ricke-Hoch et al.   CARDIOVASCULAR RESEARCH

Critical Role for Lysine 685 in Gene Expression Mediated by Transcription Factor Unphosphorylated STAT3

(2014) Maupali Dasgupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac fibroblasts mediate IL-17A–driven inflammatory dilated cardiomyopathy

(2014) Lei Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

(2014) Mirko C Sobotta et al.   Nature Chemical Biology

Protective Role of the Cholinergic Anti-Inflammatory Pathway in a Mouse Model of Viral Myocarditis

(2014) Zheng Cheng et al.   PLoS One

Cytokine-Induced Slowing of STAT3 Nuclear Import; Faster Basal Trafficking of the STAT3β Isoform

(2014) Ivan H. W. Ng et al.   TRAFFIC

Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling

(2014) Na Xu et al.   Epigenetics & Chromatin

STAT1/3 and ERK1/2 Synergistically Regulate Cardiac Fibrosis Induced by High Glucose

(2013) Bin Dai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy

(2013) Annalisa Camporeale et al.   EMBO Molecular Medicine

Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation

(2013) Fouad A Zouein et al.   HYPERTENSION RESEARCH

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

(2013) Julie Halkein et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vivo Delivery of Adenoviral Vector Containing Interleukin-17 Receptor A Reduces Cardiac Remodeling and Improves Myocardial Function in Viral Myocarditis Leading to Dilated Cardiomyopathy

(2013) Yuquan Xie et al.   PLoS One

Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration

(2013) Y. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-10 Treatment Attenuates Pressure Overload–Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3–Dependent Inhibition of Nuclear Factor-κB

(2012) Suresh Kumar Verma et al.   CIRCULATION

Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA

(2012) Olga A. Timofeeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction

(2012) Toyoharu Oba et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice

(2012) N Chin Lai et al.   LABORATORY INVESTIGATION

Acyloxy Nitroso Compounds Inhibit LIF Signaling in Endothelial Cells and Cardiac Myocytes: Evidence That STAT3 Signaling Is Redox-Sensitive

(2012) Carlos Zgheib et al.   PLoS One

Protective Function of STAT3 in CVB3-Induced Myocarditis

(2012) Diana Lindner et al.   Cardiology Research and Practice

Lentivirus mediated IL-17R blockade improves diastolic cardiac function in spontaneously hypertensive rats

(2011) Wei Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) Attenuates Interleukin-6 (IL-6)-induced Collagen Synthesis and Resultant Hypertrophy in Rat Heart

(2011) Saiful Anam Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning

(2011) Roberto Bolli et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

(2010) Kerstin Boengler et al.   BASIC RESEARCH IN CARDIOLOGY

Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction

(2010) Denise Hilfiker-Kleiner et al.   CIRCULATION

Unphosphorylated STAT and heterochromatin protect genome stability

(2010) Shian-Jang Yan et al.   FASEB JOURNAL

Th17 Cells Contribute to Viral Replication in Coxsackievirus B3-Induced Acute Viral Myocarditis

(2010) J. Yuan et al.   JOURNAL OF IMMUNOLOGY

The Functions of Signal Transducers and Activators of Transcriptions 1 and 3 as Cytokine-Inducible Proteins

(2010) HyeonJoo Cheon et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

IL-17 and IL-22: siblings, not twins

(2010) Stefanie Eyerich et al.   TRENDS IN IMMUNOLOGY

JAK redux: a second look at the regulation and role of JAKs in the heart

(2009) Mazen Kurdi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy

(2009) Hong Yue et al.   CARDIOVASCULAR RESEARCH

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Angiotensin II Activates Signal Transducer and Activators of Transcription 3 via Rac1 in Atrial Myocytes and Fibroblasts

(2008) Chia-Ti Tsai et al.   CIRCULATION

Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability

(2008) Song Shi et al.   NATURE CELL BIOLOGY