Astrocytes and Microglia as Major Players of Myelin Production in Normal and Pathological Conditions

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

(2020) Khalil S. Rawji et al.   ACTA NEUROPATHOLOGICA

Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

(2020) Jason R. Plemel et al.   Science Advances

Astrocyte ablation induced by La-aminoadipate (L-AAA) potentiates remyelination in a cuprizone demyelinating mouse model

(2019) Soheila Madadi et al.   METABOLIC BRAIN DISEASE

CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE

(2019) Agnieszka Wlodarczyk et al.   Frontiers in Cellular Neuroscience

Galectin-3 (MAC-2) Controls Microglia Phenotype Whether Amoeboid and Phagocytic or Branched and Non-phagocytic by Regulating the Cytoskeleton

(2019) Fanny Reichert et al.   Frontiers in Cellular Neuroscience

Aligned Brain Extracellular Matrix Promotes Differentiation and Myelination of Human-Induced Pluripotent Stem Cell-Derived Oligodendrocytes

(2019) Ann-Na Cho et al.   ACS Applied Materials & Interfaces

The Shh receptor Boc is important for myelin formation and repair

(2019) Mary Zakaria et al.   DEVELOPMENT

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

(2019) Marta Lombardi et al.   ACTA NEUROPATHOLOGICA

Central nervous system regeneration is driven by microglia necroptosis and repopulation

(2019) Amy F. Lloyd et al.   NATURE NEUROSCIENCE

Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination

(2019) Jureepon Roboon et al.   Frontiers in Cellular Neuroscience

Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity

(2019) Alwin Kamermans et al.   Frontiers in Immunology

Activin receptors regulate the oligodendrocyte lineage in health and disease

(2018) Alessandra Dillenburg et al.   ACTA NEUROPATHOLOGICA

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis

(2018) Alazne Zabala et al.   EMBO Molecular Medicine

The extracellular matrix: Focus on oligodendrocyte biology and targeting CSPGs for remyelination therapies

(2018) Annie Pu et al.   GLIA

Astrocyte disruption of neurovascular communication is linked to cortical damage in an animal model of multiple sclerosis

(2018) Raya Eilam et al.   GLIA

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain

(2018) Jin A. Shin et al.   NEUROPHARMACOLOGY

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

mCSF-Induced Microglial Activation Prevents Myelin Loss and Promotes Its Repair in a Mouse Model of Multiple Sclerosis

(2018) Nathalie Laflamme et al.   Frontiers in Cellular Neuroscience

Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia

(2018) Yana Zorina et al.   Scientific Reports

Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination

(2018) Kimberley D. Bruce et al.   Frontiers in Molecular Neuroscience

Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

(2018) Nicolau Beckmann et al.   Acta Neuropathologica Communications

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model

(2018) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia

(2018) M. Mecha et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial modulation through colony-stimulating factor-1 receptor inhibition attenuates demyelination

(2018) Victoria Sofía Berenice Wies Mancini et al.   GLIA

The formation of a glial scar does not prohibit remyelination in an animal model of multiple sclerosis

(2018) Michaela Tanja Haindl et al.   GLIA

miR‐223 promotes regenerative myeloid cell phenotype and function in the demyelinated central nervous system

(2018) Dylan A. Galloway et al.   GLIA

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity

(2018) Ari Waisman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of myelin structure and conduction velocity by perinodal astrocytes

(2018) Dipankar J. Dutta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia and early brain development: An intimate journey

(2018) Morgane S. Thion et al.   SCIENCE

CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously

(2017) Tsuyoshi Hattori et al.   GLIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60

(2017) Yunhong Li et al.   Molecular Medicine Reports

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Intrathecal insulin-like growth factor 1 but not insulin enhances myelin repair in young and aged rats

(2017) Martin Hlavica et al.   NEUROSCIENCE LETTERS

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Oligodendroglial myelination requires astrocyte-derived lipids

(2017) Nutabi Camargo et al.   PLOS BIOLOGY

Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology

(2016) Gerald Ponath et al.   BRAIN

Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

(2016) Caroline Guglielmetti et al.   GLIA

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

(2016) Luke M. Healy et al.   JOURNAL OF IMMUNOLOGY

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin

(2016) Bartosz Bielecki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

(2016) Michael B. Keough et al.   Nature Communications

Human iPSC-Derived Immature Astroglia Promote Oligodendrogenesis by Increasing TIMP-1 Secretion

(2016) Peng Jiang et al.   Cell Reports

Cholesterol in myelin biogenesis and hypomyelinating disorders

(2015) Gesine Saher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

(2015) Muktha S. Natrajan et al.   BRAIN

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9

(2015) Maren Lindner et al.   BRAIN

Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury

(2015) Shan-Feng Ma et al.   BRAIN BEHAVIOR AND IMMUNITY

Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness

(2015) Verónica Murcia-Belmonte et al.   Brain Structure & Function

Astrocyte development: A Guide for the Perplexed

(2015) Anna Victoria Molofsky et al.   GLIA

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Silencing IFN-γ Binding/Signaling in Astrocytes versus Microglia Leads to Opposite Effects on Central Nervous System Autoimmunity

(2015) Xiaoli Ding et al.   JOURNAL OF IMMUNOLOGY

Laminin promotes metalloproteinase-mediated dystroglycan processing to regulate oligodendrocyte progenitor cell proliferation

(2015) Cindy V. Leiton et al.   JOURNAL OF NEUROCHEMISTRY

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

(2015) S. Moyon et al.   JOURNAL OF NEUROSCIENCE

MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination

(2015) Z. Yu et al.   JOURNAL OF NEUROSCIENCE

Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor

(2015) N. Miyamoto et al.   JOURNAL OF NEUROSCIENCE

Stimulation of Monocytes, Macrophages, and Microglia by Amphotericin B and Macrophage Colony-Stimulating Factor Promotes Remyelination

(2015) A. Doring et al.   JOURNAL OF NEUROSCIENCE

Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases

(2015) Chen Chen et al.   TRENDS IN MOLECULAR MEDICINE

Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination

(2015) Hanzhi Wang et al.   Frontiers in Cellular Neuroscience

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

(2015) Stefanie Giera et al.   Nature Communications

Macrophages in spinal cord injury: Phenotypic and functional change from exposure to myelin debris

(2014) Xi Wang et al.   GLIA

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis

(2014) Roy Y. Kim et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex

(2014) G. S. Tomassy et al.   SCIENCE

Phagocytic receptors activate and immune inhibitory receptor SIRPα inhibits phagocytosis through paxillin and cofilin

(2014) Miri Gitik et al.   Frontiers in Cellular Neuroscience

Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions

(2013) Claudia Wrzos et al.   ACTA NEUROPATHOLOGICA

Fibronectin aggregation in multiple sclerosis lesions impairs remyelination

(2013) Josephine M. J. Stoffels et al.   BRAIN

Regulation of oligodendrocyte precursor migration during development, in adulthood and in pathology

(2013) Fernando de Castro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Astrocyte-specific activation of TNFR2 promotes oligodendrocyte maturation by secretion of leukemia inhibitory factor

(2013) Roman Fischer et al.   GLIA

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

The effect of glia-glia interactions on oligodendrocyte precursor cell biology during development and in demyelinating diseases

(2013) Diego Clemente et al.   Frontiers in Cellular Neuroscience

hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury

(2013) Peng Jiang et al.   Nature Communications

Differential roles of astrocyte and microglia in supporting oligodendrocyte development and myelination in vitro

(2013) Yi Pang et al.   Brain and Behavior

Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development

(2012) María Cristina Ortega et al.   GLIA

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin

(2012) Smadar Hadas et al.   Journal of Neuroinflammation

Ferritin Stimulates Oligodendrocyte Genesis in the Adult Spinal Cord and Can Be Transferred from Macrophages to NG2 Cells In Vivo

(2012) D. L. Schonberg et al.   JOURNAL OF NEUROSCIENCE

Panglial Gap Junctional Communication is Essential for Maintenance of Myelin in the CNS

(2012) O. Tress et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Distinct Spatio-Temporal Extracellular Matrix Accumulation within Demyelinated Spinal Cord Lesions in Theiler's Murine Encephalomyelitis

(2011) Verena Haist et al.   BRAIN PATHOLOGY

Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function

(2011) L A Pasquini et al.   CELL DEATH AND DIFFERENTIATION

Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation

(2011) F. Haroon et al.   JOURNAL OF IMMUNOLOGY

The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes

(2011) Justin R. Siebert et al.   JOURNAL OF NEUROCHEMISTRY

Functional Duality of Astrocytes in Myelination

(2011) B. Nash et al.   JOURNAL OF NEUROSCIENCE

FGF-2 and Anosmin-1 Are Selectively Expressed in Different Types of Multiple Sclerosis Lesions

(2011) D. Clemente et al.   JOURNAL OF NEUROSCIENCE

Dorsally and Ventrally Derived Oligodendrocytes Have Similar Electrical Properties but Myelinate Preferred Tracts

(2011) R. B. Tripathi et al.   JOURNAL OF NEUROSCIENCE

Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate

(2011) J. E. Rinholm et al.   JOURNAL OF NEUROSCIENCE

Demyelination versus remyelination in progressive multiple sclerosis

(2010) Stephan Bramow et al.   BRAIN

Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors

(2010) SunJa Kim et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective

(2010) Nicolas Froger et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Fibronectin attenuates process outgrowth in oligodendrocytes by mislocalizing MMP-9 activity

(2009) Zuzana Šišková et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Myelin repair strategies: a cellular view

(2008) Vittorio Gallo et al.   CURRENT OPINION IN NEUROLOGY

A novel role for anosmin-1 in the adhesion and migration of oligodendrocyte precursors

(2008) Ana Bribián et al.   Developmental Neurobiology

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Interferon-γ-dependent cytotoxic activation of human astrocytes and astrocytoma cells

(2008) Sadayuki Hashioka et al.   NEUROBIOLOGY OF AGING

Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System

(2008) Trent A. Watkins et al.   NEURON