Silencing IFN-γ Binding/Signaling in Astrocytes versus Microglia Leads to Opposite Effects on Central Nervous System Autoimmunity

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Astrocyte-derived lactosylceramide implicated in multiple sclerosis

(2014) Abdolmohamad Rostami et al.   NATURE MEDICINE

Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines and lymphocyte trafficking

(2013) Iain Comerford et al.   BRITISH JOURNAL OF HAEMATOLOGY

Microglial Activation Milieu Controls Regulatory T Cell Responses

(2013) F. Ebner et al.   JOURNAL OF IMMUNOLOGY

White matter astrocytes in health and disease

(2013) I. Lundgaard et al.   NEUROSCIENCE

Review ofThe Biology of Multiple Sclerosis

(2013) Bardia Nourbakhsh   JAMA Neurology

The Control of the Specificity of CD4 T Cell Responses: Thresholds, Breakpoints, and Ceilings

(2013) Andrea J. Sant et al.   Frontiers in Immunology

IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci

(2012) Eunyoung Lee et al.   Journal of Neuroinflammation

CNS-specific Therapy for Ongoing EAE by Silencing IL-17 Pathway in Astrocytes

(2012) Yaping Yan et al.   MOLECULAR THERAPY

IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability

(2012) Claudia Hindinger et al.   PLoS One

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis?

(2010) Amy E. Lovett-Racke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

IL-23 modulated myelin-specific T cells induce EAE via an IFNγ driven, IL-17 independent pathway

(2010) Mark A. Kroenke et al.   BRAIN BEHAVIOR AND IMMUNITY

EAE mediated by a non-IFN-γ/non-IL-17 pathway

(2010) Mark A. Kroenke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

(2009) Jingxian Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute in vivo exposure to interferon-  enables resident brain dendritic cells to become effective antigen presenting cells

(2009) A. Gottfried-Blackmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFN-  receptor signaling mediates spinal microglia activation driving neuropathic pain

(2009) M. Tsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes in multiple sclerosis: A product of their environment

(2008) A. Nair et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis

(2008) Jason R. Lees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-γ-dependent cytotoxic activation of human astrocytes and astrocytoma cells

(2008) Sadayuki Hashioka et al.   NEUROBIOLOGY OF AGING

How interferon-γ keeps autoimmune diseases in check

(2008) Hilde Kelchtermans et al.   TRENDS IN IMMUNOLOGY