A glimpse into the molecular mechanism of integral membrane proteins through hydrogen–deuterium exchange mass spectrometry

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

(2019) Jonathan J. Ruprecht et al.   CELL

ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

(2019) Robin A Corey et al.   eLife

Assembly of a GPCR-G Protein Complex

(2019) Yang Du et al.   CELL

Hydrogen-deuterium exchange mass spectrometry of membrane proteins in lipid nanodiscs

(2019) Michelle Redhair et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors

(2019) Reza Dastvan et al.   SCIENCE

Conformational dynamics of the human serotonin transporter during substrate and drug binding

(2019) Ingvar R. Möller et al.   Nature Communications

Improving the sequence coverage of integral membrane proteins during hydrogen/deuterium exchange mass spectrometry experiments.

(2019) Ingvar R. Möller et al.   ANALYTICAL CHEMISTRY

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

(2019) Glenn R. Masson et al.   NATURE METHODS

Substrate-induced conformational dynamics of the dopamine transporter

(2019) Anne Kathrine Nielsen et al.   Nature Communications

HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

(2019) Zainab Ahdash et al.   eLife

Integrating hydrogen–deuterium exchange mass spectrometry with molecular dynamics simulations to probe lipid-modulated conformational changes in membrane proteins

(2019) Chloe Martens et al.   Nature Protocols

Bridging protein structure, dynamics, and function using hydrogen/deuterium‐exchange mass spectrometry

(2019) Edgar A. Hodge et al.   PROTEIN SCIENCE

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

(2019) Sarah V. Faull et al.   Nature Communications

Dynamics of ABC Transporter P-glycoprotein in Three Conformational States

(2019) Noah Kopcho et al.   Scientific Reports

Comparison of mechanistic transport cycle models of ABC exporters

(2018) Dániel Szöllősi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Conformational dynamics of P-glycoprotein in lipid nanodiscs and detergent micelles reveal complex motions on a wide time scale

(2018) Mavis Jiarong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Xenobiotic Extrusion Mechanism of the MATE Transporter NorM_PS from Pseudomonas stutzeri

(2018) Martin Lorenz Eisinger et al.   JOURNAL OF MOLECULAR BIOLOGY

Native State Organization of Outer Membrane Porins Unraveled by HDx-MS

(2018) Danilo Donnarumma et al.   JOURNAL OF PROTEOME RESEARCH

Contemporary hydrogen deuterium exchange mass spectrometry

(2018) Irina Oganesyan et al.   METHODS

Orthosteric and allosteric action of the C5a receptor antagonists

(2018) Heng Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational analysis of complex protein states by hydrogen/deuterium exchange mass spectrometry (HDX-MS): Challenges and emerging solutions

(2018) Esben Trabjerg et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Orthosteric and allosteric action of the C5a receptor antagonists

(2018) Heng Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT

(2018) Patrick S. Merkle et al.   Science Advances

Biophysical and functional characterization of Norrin signaling through Frizzled4

(2018) Injin Bang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comment on Houde, D.; Berkowitz, S. A.; Engen, J. R., The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies. J. Pharm. Sci. 2011, 100, 2071-2086.

(2018) David D. Weis   JOURNAL OF PHARMACEUTICAL SCIENCES

Quantitative Evaluation of Native Protein Folds and Assemblies by Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS)

(2018) Matthew J. Harris et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Direct protein-lipid interactions shape the conformational landscape of secondary transporters

(2018) Chloe Martens et al.   Nature Communications

An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery

(2017) Glenn R. Masson et al.   Expert Opinion on Drug Discovery

Dynamic distinctions in the Na+/Ca2+exchanger adopting the inward- and outward-facing conformational states

(2017) Moshe Giladi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and allosteric inhibition of excitatory amino acid transporter 1

(2017) Juan C. Canul-Tec et al.   NATURE

Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer

(2017) Suraj Adhikary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced conformational dynamics of theEscherichia coliNa+/H+antiporter NhaA revealed by hydrogen/deuterium exchange mass spectrometry

(2017) Martin Lorenz Eisinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

(2016) Zhaolin Chen et al.   CANCER LETTERS

The Evolving Contribution of Mass Spectrometry to Integrative Structural Biology

(2016) Marco Faini et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

X-ray structures and mechanism of the human serotonin transporter

(2016) Jonathan A. Coleman et al.   NATURE

A method for detergent-free isolation of membrane proteins in their local lipid environment

(2016) Sarah C Lee et al.   Nature Protocols

Elevating the alternating-access model

(2016) Renae M Ryan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Load-dependent destabilization of the γ-rotor shaft in FOF1ATP synthase revealed by hydrogen/deuterium-exchange mass spectrometry

(2016) Siavash Vahidi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevating the alternating-access model

(2016) Renae M Ryan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Challenges in the Interpretation of Protein H/D Exchange Data: A Molecular Dynamics Simulation Perspective

(2015) Robert G. McAllister et al.   BIOCHEMISTRY

Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry

(2015) Nguyen Minh Duc et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

A Conformational Investigation of Propeptide Binding to the Integral Membrane Protein γ-Glutamyl Carboxylase Using Nanodisc Hydrogen Exchange Mass Spectrometry

(2014) Christine H. Parker et al.   BIOCHEMISTRY

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Sodium recognition by the Na+/Ca2+exchanger in the outward-facing conformation

(2014) Fabrizio Marinelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

(2013) Aravind Penmatsa et al.   JOURNAL OF PHYSIOLOGY-LONDON

X-ray structure of dopamine transporter elucidates antidepressant mechanism

(2013) Aravind Penmatsa et al.   NATURE

Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics

(2013) Ute Distler et al.   NATURE METHODS

Structural and mechanistic insights into prokaryotic energy-coupling factor transporters

(2013) Dirk J. Slotboom   NATURE REVIEWS MICROBIOLOGY

Conformational Dynamics of a Membrane Transport Protein Probed by H/D Exchange and Covalent Labeling: The Glycerol Facilitator

(2012) Yan Pan et al.   JOURNAL OF MOLECULAR BIOLOGY

Nepenthesin from Monkey Cups for Hydrogen/Deuterium Exchange Mass Spectrometry

(2012) Martial Rey et al.   MOLECULAR & CELLULAR PROTEOMICS

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

(2012) Harini Krishnamurthy et al.   NATURE

Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations

(2012) S. Mehmood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insight into the Ion-Exchange Mechanism of the Sodium/Calcium Exchanger

(2012) J. Liao et al.   SCIENCE

Yeast ADP/ATP Carrier Isoform 2

(2011) Benjamin Clémençon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX

(2011) Graham M. West et al.   STRUCTURE

Dynamics of the β2-Adrenergic G-Protein Coupled Receptor Revealed by Hydrogen−Deuterium Exchange

(2010) Xi Zhang et al.   ANALYTICAL CHEMISTRY

Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry

(2010) Christine M. Hebling et al.   ANALYTICAL CHEMISTRY

False EX1 signatures caused by sample carryover during HX MS analyses

(2010) Jing Fang et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Conformational Dynamics of the Bovine Mitochondrial ADP/ATP Carrier Isoform 1 Revealed by Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry

(2010) Martial Rey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease

(2010) Xin Ye et al.   TRENDS IN MOLECULAR MEDICINE

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

The impact of GPCR structures on pharmacology and structure-based drug design

(2009) Miles Congreve et al.   BRITISH JOURNAL OF PHARMACOLOGY

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

Membrane Proteins Solubilized Intact in Lipid Containing Nanoparticles Bounded by Styrene Maleic Acid Copolymer

(2009) Timothy J. Knowles et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recombinant immobilized rhizopuspepsin as a new tool for protein digestion in hydrogen/deuterium exchange mass spectrometry

(2009) Martial Rey et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Sodium-Coupled Neurotransmitter Transporters

(2008) Baruch I. Kanner et al.   CHEMICAL REVIEWS

Structural Elements Involved in Proton Translocation by CytochromecOxidase as Revealed by Backbone Amide Hydrogen−Deuterium Exchange of the E286H Mutant†

(2007) Laura S. Busenlehner et al.   BIOCHEMISTRY