Dynamics of ABC Transporter P-glycoprotein in Three Conformational States

Conformational dynamics of the human serotonin transporter during substrate and drug binding

(2019) Ingvar R. Möller et al.   Nature Communications

Conformational dynamics of P-glycoprotein in lipid nanodiscs and detergent micelles reveal complex motions on a wide time scale

(2018) Mavis Jiarong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RelA-Containing NFκB Dimers Have Strikingly Different DNA-Binding Cavities in the Absence of DNA

(2018) Dominic Narang et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation

(2018) Youngjin Kim et al.   SCIENCE

The conformation and dynamics of P-glycoprotein in a lipid bilayer investigated by atomic force microscopy

(2018) K.P. Sigdel et al.   BIOCHEMICAL PHARMACOLOGY

Structural basis of MsbA-mediated lipopolysaccharide transport

(2017) Wei Mi et al.   NATURE

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

Blood-Brain Barrier ABC-transporter P-glycoprotein in Alzheimer's Disease: Still a Suspect?

(2016) Danielle Assema et al.   CURRENT PHARMACEUTICAL DESIGN

The diverse and expanding role of mass spectrometry in structural and molecular biology

(2016) Philip Lössl et al.   EMBO JOURNAL

Structural and dynamic perspectives on the promiscuous transport activity of P-glycoprotein

(2016) Nandhitha Subramanian et al.   NEUROCHEMISTRY INTERNATIONAL

Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure

(2016) S. C. T. Nicklisch et al.   Science Advances

The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein

(2015) Tip W. Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and mechanism of an active lipid-linked oligosaccharide flippase

(2015) Camilo Perez et al.   NATURE

Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014

(2014) Gregory F. Pirrone et al.   ANALYTICAL CHEMISTRY

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Binding Stabilizes a Pre-translocation Intermediate in the ATP-binding Cassette Transport Protein MsbA

(2013) Rupak Doshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

(2013) A. B. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using Hydrogen/Deuterium Exchange Mass Spectrometry to Define the Specific Interactions of the Phospholipase A2Superfamily with Lipid Substrates, Inhibitors, and Membranes

(2012) Jian Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

(2012) Mi Sun Jin et al.   NATURE

Dynamics of a bacterial multidrug ABC transporter in the inward- and outward-facing conformations

(2012) S. Mehmood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Ligand-induced Conformational Rearrangements in P-glycoprotein as Probed by Fluorescence Resonance Energy Transfer Spectroscopy

(2011) Brandy Verhalen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

(2010) Alena Siarheyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1

(2009) Daniel A.P. Gutmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular basis of multidrug transport by ABC transporters

(2008) Markus A. Seeger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS