Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry

A Conformational Investigation of Propeptide Binding to the Integral Membrane Protein γ-Glutamyl Carboxylase Using Nanodisc Hydrogen Exchange Mass Spectrometry

(2014) Christine H. Parker et al.   BIOCHEMISTRY

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

The Structural Basis of G-Protein-Coupled Receptor Signaling (Nobel Lecture)

(2013) Brian Kobilka   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiscale modelling to understand the self-assembly mechanism of human β2-adrenergic receptor in lipid bilayer

(2013) Anirban Ghosh et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Detergent-free mass spectrometry of membrane protein complexes

(2013) Jonathan T S Hopper et al.   NATURE METHODS

When detergent meets bilayer: Birth and coming of age of lipid bicelles

(2013) Ulrich H.N. Dürr et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Ice breaking in GPCR structural biology

(2012) Qiang Zhao et al.   ACTA PHARMACOLOGICA SINICA

Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review

(2012) Andrew J. Percy et al.   ANALYTICA CHIMICA ACTA

The Magic of Bicelles Lights Up Membrane Protein Structure

(2012) Ulrich H. N. Dürr et al.   CHEMICAL REVIEWS

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

High-resolution crystal structure of human protease-activated receptor 1

(2012) Cheng Zhang et al.   NATURE

A new era of GPCR structural and chemical biology

(2012) Sébastien Granier et al.   Nature Chemical Biology

Conformational Dynamics of Activation for the Pentameric Complex of Dimeric G Protein-Coupled Receptor and Heterotrimeric G Protein

(2012) Tivadar Orban et al.   STRUCTURE

Kinetic Folding Mechanism of an Integral Membrane Protein Examined by Pulsed Oxidative Labeling and Mass Spectrometry

(2011) Yan Pan et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystallizing membrane proteins using lipidic bicelles

(2011) Rachna Ujwal et al.   METHODS

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

(2011) Ka Young Chung et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Multiple ligand-specific conformations of the β2-adrenergic receptor

(2011) Alem W Kahsai et al.   Nature Chemical Biology

Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function

(2011) Beata Jastrzebska et al.   PROGRESS IN LIPID RESEARCH

Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX

(2011) Graham M. West et al.   STRUCTURE

Hydrogen exchange mass spectrometry: what is it and what can it tell us?

(2010) Sean R. Marcsisin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Dynamics of the β2-Adrenergic G-Protein Coupled Receptor Revealed by Hydrogen−Deuterium Exchange

(2010) Xi Zhang et al.   ANALYTICAL CHEMISTRY

Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry

(2010) Christine M. Hebling et al.   ANALYTICAL CHEMISTRY

Membrane proteins and proteomics: Love is possible, but so difficult

(2010) Thierry Rabilloud   ELECTROPHORESIS

Mass Spectrometry-Based GPCR Proteomics: Comprehensive Characterization of the Human Cannabinoid 1 Receptor

(2010) Nikolai Zvonok et al.   JOURNAL OF PROTEOME RESEARCH

Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins

(2010) Pil Seok Chae et al.   NATURE METHODS

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer

(2009) Juan José Fung et al.   EMBO JOURNAL

Bicellar systems for in vitro percutaneous absorption of diclofenac

(2009) L. Rubio et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structural waters define a functional channel mediating activation of the GPCR, rhodopsin

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches

(2008) Lars Konermann et al.   JOURNAL OF MASS SPECTROMETRY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY