Targeting Inflammatory-Mitochondrial Response in Major Depression: Current Evidence and Further Challenges

‘That’s the Esketamine, Baby, there’s Nothing You Can Do about It!’ An Update on Glutamatergic System in Suicidal Depression

(2020) Domenico De Berardis et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Curcumin amends Ca2+ dysregulation in microglia by suppressing the activation of P2X7 receptor

(2020) Zhen Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A preliminary study of resting brain metabolism in treatment-resistant depression before and after treatment with olanzapine-fluoxetine combination

(2020) José V. Pardo et al.   PLoS One

Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms

(2019) Gloria Castellano-Gonzalez et al.   NEUROTOXICITY RESEARCH

Mitochondria, Microglia, and the Immune System—How Are They Linked in Affective Disorders?

(2019) Carsten Culmsee et al.   Frontiers in Psychiatry

Quinolinic Acid and Nuclear Factor Erythroid 2-Related Factor 2 in Depression: Role in Neuroprogression

(2019) Yashika Bansal et al.   Frontiers in Pharmacology

Influence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episode

(2019) Leila Jahangard et al.   MOLECULAR BIOLOGY REPORTS

Neuroprotective effects of the second generation antipsychotics

(2019) Alexander T. Chen et al.   SCHIZOPHRENIA RESEARCH

Novel Neuroimmunologic Therapeutics in Depression: A Clinical Perspective on What We Know So Far

(2019) Michael Roman et al.   BRAIN BEHAVIOR AND IMMUNITY

N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes

(2019) Suwarna Chakraborty et al.   NEUROCHEMISTRY INTERNATIONAL

Oxidative stress markers imbalance in late-life depression

(2018) Breno S. Diniz et al.   JOURNAL OF PSYCHIATRIC RESEARCH

N-Acetylcysteine Reverses Anxiety and Oxidative Damage Induced by Unpredictable Chronic Stress in Zebrafish

(2018) Ricieri Mocelin et al.   MOLECULAR NEUROBIOLOGY

Are there differences in lipid peroxidation and immune biomarkers between major depression and bipolar disorder: Effects of melancholia, atypical depression, severity of illness, episode number, suicidal ideation and prior suicide attempts

(2018) Magdalena Sowa-Kućma et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Affective problems and decline in cognitive state in older adults: a systematic review and meta-analysis

(2018) A. John et al.   PSYCHOLOGICAL MEDICINE

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

Circadian rhythm and melatonin in the treatment of depression

(2018) Senthil Kumaran Satyanarayanan et al.   CURRENT PHARMACEUTICAL DESIGN

Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms

(2018) Alyssa Moore et al.   MOLECULES

Increased inflammation and brain glutamate define a subtype of depression with decreased regional homogeneity, impaired network integrity, and anhedonia

(2018) Ebrahim Haroon et al.   Translational Psychiatry

Resveratrol exerts a protective effect in chronic unpredictable mild stress–induced depressive-like behavior: involvement of the AKT/GSK3β signaling pathway in hippocampus

(2018) Jun Shen et al.   PSYCHOPHARMACOLOGY

Chronobiological theories of mood disorder

(2017) Nevin F. W. Zaki et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Mitochondrial SIRT3 and neurodegenerative brain disorders

(2017) Anamika et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Effects of ketamine administration on mTOR and reticulum stress signaling pathways in the brain after the infusion of rapamycin into prefrontal cortex

(2017) Helena M. Abelaira et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism

(2017) Lily R. Aleksandrova et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Clinical Use of Curcumin in Depression: A Meta-Analysis

(2017) Qin Xiang Ng et al.   Journal of the American Medical Directors Association

Molecular Mechanisms Underlying the Anti-depressant Effects of Resveratrol: a Review

(2017) Marcos Roberto de Oliveira et al.   MOLECULAR NEUROBIOLOGY

Mechanism of synergistic action on behavior, oxidative stress and inflammation following co-treatment with ketamine and different antidepressant classes

(2017) Gislaine Z. Réus et al.   Pharmacological Reports

A pilot study of cortical glutathione in youth with depression

(2017) Rachel D. Freed et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Oxidative stress, inflammation and treatment response in major depression

(2017) Daniel Lindqvist et al.   PSYCHONEUROENDOCRINOLOGY

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Ketamine use in current clinical practice

(2016) Mei Gao et al.   ACTA PHARMACOLOGICA SINICA

Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain

(2016) Takamasa Ishii et al.   AGING CELL

Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology

(2016) Chadi G. Abdallah et al.   BEHAVIORAL AND BRAIN SCIENCES

Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors

(2016) Karol Ramirez et al.   BRAIN BEHAVIOR AND IMMUNITY

Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine

(2016) Eric Wohleb et al.   Current Neuropharmacology

Beneficial Effects of Ramelteon on Rapid Eye Movement Sleep Behavior Disorder Associated with Parkinson's Disease - Results of a Multicenter Open Trial

(2016) Kenichi Kashihara et al.   INTERNAL MEDICINE

The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases

(2016) Jamie L. Harden et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting Oxidative Stress, Cytokines and Serotonin Interactions Via Indoleamine 2, 3 Dioxygenase by Coenzyme Q10: Role in Suppressing Depressive Like Behavior in Rats

(2016) Sally A. Abuelezz et al.   Journal of Neuroimmune Pharmacology

Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression

(2016) E Bouvier et al.   MOLECULAR PSYCHIATRY

Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions

(2016) N Kappelmann et al.   MOLECULAR PSYCHIATRY

The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder

(2016) Pawan Kumar Maurya et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression

(2016) Yong-Ku Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Evaluation of malondialdehyde, superoxide dismutase and catalase activity and their diagnostic value in drug naïve, first episode, non-smoker major depression patients and healthy controls

(2016) Mehmet Akif Camkurt et al.   PSYCHIATRY RESEARCH

Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder

(2016) Meng-Chang Tsai et al.   PSYCHIATRY RESEARCH

Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort

(2016) C. N. Black et al.   PSYCHOLOGICAL MEDICINE

Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment

(2016) S H Mellon et al.   Translational Psychiatry

Chronic selective serotonin reuptake inhibition modulates endothelial dysfunction and oxidative state in rat chronic mild stress model of depression

(2015) Vladimir V. Matchkov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Neuroimmune and neuroendocrine abnormalities in depression: two sides of the same coin

(2015) Mark A. Horowitz et al.   Annals of the New York Academy of Sciences

Cognitive psychotherapy treatment decreases peripheral oxidative stress parameters associated with major depression disorder

(2015) Fernanda N. Kaufmann et al.   BIOLOGICAL PSYCHOLOGY

Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review

(2015) Joshua D. Rosenblat et al.   Current Neuropharmacology

Glutathione redox imbalance in brain disorders

(2015) Feng Gu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Inflammation and clinical response to treatment in depression: A meta-analysis

(2015) R. Strawbridge et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Inflammatory Biomarkers as Differential Predictors of Antidepressant Response

(2015) Kenji Hashimoto   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

(2015) M. D. Weber et al.   JOURNAL OF NEUROSCIENCE

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

The Effects of Escitalopram Treatment on Oxidative/ Antioxidative Parameters in Patients with Depression

(2015) Behzat Cimen et al.   KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY

Effects of antidepressant treatment on total antioxidant capacity and free radical levels in patients with major depressive disorder

(2015) Cheng-Chen Chang et al.   PSYCHIATRY RESEARCH

Is depression associated with increased oxidative stress? A systematic review and meta-analysis

(2015) Catherine N. Black et al.   PSYCHONEUROENDOCRINOLOGY

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells

(2015) J R Yaron et al.   Cell Death & Disease

Role of Translocator Protein Density, a Marker of Neuroinflammation, in the Brain During Major Depressive Episodes

(2015) Elaine Setiawan et al.   JAMA Psychiatry

Poor Vitamin C Status is Associated with Increased Depression Symptoms Following Acute Illness in Older People

(2015) Salah Gariballa   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

BDNF Release Is Required for the Behavioral Actions of Ketamine

(2015) A. E. Lepack et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A Meta-Analysis of Oxidative Stress Markers in Depression

(2015) Tao Liu et al.   PLoS One

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

(2014) Ying Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment

(2014) Ying Xu et al.   Current Neuropharmacology

Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications

(2014) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

Do the dissociative side effects of ketamine mediate its antidepressant effects?

(2014) David A. Luckenbaugh et al.   JOURNAL OF AFFECTIVE DISORDERS

The Efficacy of AdjunctiveN-Acetylcysteine in Major Depressive Disorder

(2014) Michael Berk et al.   JOURNAL OF CLINICAL PSYCHIATRY

Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment

(2014) Piotr Gałecki et al.   Pharmacological Reports

Increased IL-6 trans-signaling in depression: focus on the tryptophan catabolite pathway, melatonin and neuroprogression

(2014) George Anderson et al.   Pharmacological Reports

Inflamed moods: A review of the interactions between inflammation and mood disorders

(2014) Joshua D. Rosenblat et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls–preliminary findings

(2014) Daniel Lindqvist et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes

(2014) A. McGirr et al.   PSYCHOLOGICAL MEDICINE

The Integrative Management of Treatment-Resistant Depression: A Comprehensive Review and Perspectives

(2014) Andre F. Carvalho et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

(2014) Y Chen et al.   Cell Death & Disease

Treatment Course With Antidepressant Therapy in Late-Life Depression

(2013) Yvette I. Sheline et al.   AMERICAN JOURNAL OF PSYCHIATRY

Metabolite profiles in the anterior cingulate cortex of depressed patients differentiate those taking N-acetyl-cysteine versus placebo

(2013) Pritha Das et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

(2013) Michael Berk et al.   BMC Medicine

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

(2013) Elísabet Alcocer-Gómez et al.   BRAIN BEHAVIOR AND IMMUNITY

Ketamine as a Fast Acting Antidepressant: Current Knowledge and Open Questions

(2013) Giacomo Salvadore et al.   CNS Neuroscience & Therapeutics

COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS

(2013) Roger S. McIntyre et al.   DEPRESSION AND ANXIETY

Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle Through Reversible Enzymatic Deacetylation

(2013) E. Jing et al.   DIABETES

Gender-based differences in oxidative stress parameters do not underlie the differences in mood disorders susceptibility between sexes

(2013) C. Wiener et al.   EUROPEAN PSYCHIATRY

Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

(2013) Joanna Rybka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Connecting inflammation with glutamate agonism in suicidality

(2013) Sophie Erhardt et al.   NEUROPSYCHOPHARMACOLOGY

Glucocorticoid-Related Molecular Signaling Pathways Regulating Hippocampal Neurogenesis

(2013) Christoph Anacker et al.   NEUROPSYCHOPHARMACOLOGY

NMDA Receptor Blockade by Ketamine Abrogates Lipopolysaccharide-Induced Depressive-Like Behavior in C57BL/6J Mice

(2013) Adam K Walker et al.   NEUROPSYCHOPHARMACOLOGY

Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications

(2013) J.C. Felger et al.   NEUROSCIENCE

Potential roles of zinc in the pathophysiology and treatment of major depressive disorder

(2013) Walter Swardfager et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis

(2013) C. Anacker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

(2013) Adrian L. Lopresti et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The promise of N-acetylcysteine in neuropsychiatry

(2013) Michael Berk et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Sirtuins: from metabolic regulation to brain aging

(2013) Wenzhen Duan   Frontiers in Aging Neuroscience

Mechanisms of antidepressant resistance

(2013) Wissam El-Hage et al.   Frontiers in Pharmacology

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia

(2012) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Prediction of longer-term outcome of treatment-resistant depression in tertiary care

(2012) Abebaw Fekadu et al.   BRITISH JOURNAL OF PSYCHIATRY

The Role of Oxidative Stress in Depressive Disorders

(2012) Tanja Maria Michel et al.   CURRENT PHARMACEUTICAL DESIGN

The clinical implications of cognitive impairment and allostatic load in bipolar disorder

(2012) E. Vieta et al.   EUROPEAN PSYCHIATRY

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Dangerous Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome

(2012) Fabio Martinon   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Targeting cyclooxygenase-2 in depression is not a viable therapeutic approach and may even aggravate the pathophysiology underpinning depression

(2012) Michael Maes   METABOLIC BRAIN DISEASE

Nitric oxide plasma concentration associated with cognitive impairment in patients with recurrent depressive disorder

(2012) Monika Talarowska et al.   NEUROSCIENCE LETTERS

Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity

(2012) Suzhen Dong et al.   PLoS One

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

(2012) S. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment-resistant depression: therapeutic trends, challenges, and future directions

(2012) Al-harbi   Patient Preference and Adherence

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Microglial Activation – Tuning and Pruning Adult Neurogenesis

(2012) Christine T. Ekdahl   Frontiers in Pharmacology

Effects of Fluoxetine on the Oxidative Status of Peripheral Blood Leucocytes of Restraint-Stressed Mice

(2011) Silvia Novío et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Developing risk prediction models for type 2 diabetes: a systematic review of methodology and reporting

(2011) Gary S Collins et al.   BMC Medicine

Peripheral oxidative damage in early-stage mood disorders: a nested population-based case-control study

(2011) Pedro V. S. Magalhães et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Malondialdehyde plasma concentration correlates with declarative and working memory in patients with recurrent depressive disorder

(2011) Monika Talarowska et al.   MOLECULAR BIOLOGY REPORTS

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

(2011) C Anacker et al.   MOLECULAR PSYCHIATRY

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus

(2011) Gislaine Z. Réus et al.   Oxidative Medicine and Cellular Longevity

Venlafaxine protects against stress-induced oxidative DNA damage in hippocampus during antidepressant testing in mice

(2011) Basel A. Abdel-Wahab et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Rapid decrease in depressive symptoms with an N-methyl-d-aspartate antagonist in ECT-resistant major depression

(2011) Lobna Ibrahim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

(2011) Vahap Ozan Kotan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

(2010) Nancy Diazgranados et al.   ARCHIVES OF GENERAL PSYCHIATRY

Immune suppression and immune activation in depression

(2010) Joshua Blume et al.   BRAIN BEHAVIOR AND IMMUNITY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Role of the mTOR signaling pathway in the rapid antidepressant action of ketamine

(2010) Kenji Hashimoto   Expert Review of Neurotherapeutics

Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder

(2010) Nancy DiazGranados et al.   JOURNAL OF CLINICAL PSYCHIATRY

Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression

(2010) R C Shelton et al.   MOLECULAR PSYCHIATRY

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Beyond the serotonin hypothesis: Mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders

(2010) Ann Gardner et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

(2010) Michael Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Influence of Comorbid Personality Disorder and Neuroticism on Treatment Outcome in First Episode Depression

(2010) Camilla Bock et al.   PSYCHOPATHOLOGY

Inflammation Bares a Dark Side

(2010) J. Couzin-Frankel   SCIENCE

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Stuck in a rut: rethinking depression and its treatment

(2010) Paul E. Holtzheimer et al.   TRENDS IN NEUROSCIENCES

Biomarkers to Predict Antidepressant Response

(2010) Andrew F. Leuchter et al.   Current Psychiatry Reports

Atypical Antipsychotic Augmentation in Major Depressive Disorder: A Meta-Analysis of Placebo-Controlled Randomized Trials

(2009) J. Craig Nelson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mitochondrial calcium function and dysfunction in the central nervous system

(2009) David G. Nicholls   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression

(2009) Rebecca B. Price et al.   BIOLOGICAL PSYCHIATRY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Emerging role of glutamate in the pathophysiology of major depressive disorder

(2009) Kenji Hashimoto   BRAIN RESEARCH REVIEWS

Antioxidative enzymes and increased oxidative stress in depressive women

(2009) Jana Kodydková et al.   CLINICAL BIOCHEMISTRY

Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain

(2009) Jian-You Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Clinical issues in considering vagus nerve stimulation for treatment-resistant depression

(2009) A. John Rush et al.   EXPERIMENTAL NEUROLOGY

Zinc supplementation augments efficacy of imipramine in treatment resistant patients: A double blind, placebo-controlled study

(2009) Marcin Siwek et al.   JOURNAL OF AFFECTIVE DISORDERS

Neurocircuitry of Mood Disorders

(2009) Joseph L Price et al.   NEUROPSYCHOPHARMACOLOGY

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders

(2009) Rodrigo Machado-Vieira et al.   NEUROSCIENTIST

Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats

(2009) Yu-Cheng Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins

(2009) Ivy K. M. Law et al.   PROTEOMICS

Association Between Type D Personality, Depression, and Oxidative Stress in Patients With Chronic Heart Failure

(2009) Nina Kupper et al.   PSYCHOSOMATIC MEDICINE

Antioxidant and radical scavenging properties of curcumin

(2008) Tuba Ak et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

What happens to patients with treatment-resistant depression? A systematic review of medium to long term outcome studies

(2008) Abebaw Fekadu et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2

(2008) Saba Aid et al.   Journal of Neuroinflammation

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants

(2008) Jaegyu Hwang et al.   NEUROPHARMACOLOGY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of antidepressants on mRNA levels of antioxidant enzymes in human monocytic U-937 cells

(2008) Andreas Johannes Schmidt et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

In vivo antioxidant status: A putative target of antidepressant action

(2008) Ayesha Zafir et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The HPA axis in major depression: classical theories and new developments

(2008) Carmine M. Pariante et al.   TRENDS IN NEUROSCIENCES

A detailed examination of cytokine abnormalities in Major Depressive Disorder

(2007) N.M. Simon et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex

(2007) Jason J. Radley et al.   JOURNAL OF COMPARATIVE NEUROLOGY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

Pro-inflammatory cytokines and treatment response to escitaloprsam in major depressive disorder

(2007) Triin Eller et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH