The Integrative Management of Treatment-Resistant Depression: A Comprehensive Review and Perspectives

Aripiprazole Augmentation in Major Depressive Disorder: A Double-Blind, Placebo-Controlled Study in Patients with Inadequate Response to Antidepressants

(2016) Robert M. Berman et al.   CNS SPECTRUMS

Pharmacological management of unipolar depression

(2013) G. S. Malhi et al.   ACTA PSYCHIATRICA SCANDINAVICA

A Model of Placebo Response in Antidepressant Clinical Trials

(2013) Bret R. Rutherford et al.   AMERICAN JOURNAL OF PSYCHIATRY

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

(2013) Michael Berk et al.   BMC Medicine

Serotonergic Drugs for Depression and Beyond

(2013) Stephen M. Stahl et al.   CURRENT DRUG TARGETS

Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders

(2013) Kenji Hashimoto et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

A Randomized Controlled Trial of the Efficacy and Safety of Lisdexamfetamine Dimesylate as Augmentation Therapy in Adults With Residual Symptoms of Major Depressive Disorder After Treatment With Escitalopram

(2013) Madhukar H. Trivedi et al.   JOURNAL OF CLINICAL PSYCHIATRY

A Randomized, Double-Blind, Placebo-Controlled Trial of Pramipexole Augmentation in Treatment-Resistant Major Depressive Disorder

(2013) Cristina Cusin et al.   JOURNAL OF CLINICAL PSYCHIATRY

Increased Serotonin Receptor 1A Binding in Major Depressive Disorder after Psychotherapy, but Not after SSRI Pharmacotherapy, Is Related to Improved Social Functioning Capacity

(2013) Hasse Karlsson et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

The Risks and Benefits of Antidepressants to Treat Pediatric-Onset Depression and Anxiety Disorders: A Developmental Perspective

(2013) James F. Leckman   PSYCHOTHERAPY AND PSYCHOSOMATICS

Excessive Mood Elevation and Behavioral Activation with Antidepressant Treatment of Juvenile Depressive and Anxiety Disorders: A Systematic Review

(2013) Emanuela Offidani et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Adjunctive Atypical Antipsychotic Treatment for Major Depressive Disorder: A Meta-Analysis of Depression, Quality of Life, and Safety Outcomes

(2013) Glen I. Spielmans et al.   PLOS MEDICINE

l-Methylfolate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials

(2012) George I. Papakostas et al.   AMERICAN JOURNAL OF PSYCHIATRY

Novel therapeutic targets in depression: Minocycline as a candidate treatment

(2012) Joanna K. Soczynska et al.   BEHAVIOURAL BRAIN RESEARCH

A Randomized Trial of a Low-Trapping Nonselective N-Methyl-D-Aspartate Channel Blocker in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013

(2012) Lakshmi N Yatham et al.   BIPOLAR DISORDERS

Is diagnosis enough to guide interventions in mental health? Using case formulation in clinical practice

(2012) Craig A Macneil et al.   BMC Medicine

The impact of statins on psychological wellbeing: a systematic review and meta-analysis

(2012) Adrienne O'Neil et al.   BMC Medicine

Early vs. conventional switching of antidepressants in patients with MDD and moderate to severe pain: A double-blind randomized study

(2012) Irene Romera et al.   JOURNAL OF AFFECTIVE DISORDERS

Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: Randomized double-blind placebo-controlled study

(2012) Seyed-Hesameddin Abbasi et al.   JOURNAL OF AFFECTIVE DISORDERS

Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system

(2012) L.A. Carvalho et al.   JOURNAL OF AFFECTIVE DISORDERS

Oral Scopolamine Augmentation in Moderate to Severe Major Depressive Disorder

(2012) Danial Khajavi et al.   JOURNAL OF CLINICAL PSYCHIATRY

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Christopher J L Murray et al.   LANCET

Cognitive behavioural therapy as an adjunct to pharmacotherapy for primary care based patients with treatment resistant depression: results of the CoBalT randomised controlled trial

(2012) Nicola Wiles et al.   LANCET

Pioglitazone Adjunctive Therapy for Moderate-to-Severe Major Depressive Disorder: Randomized Double-Blind Placebo-Controlled Trial

(2012) Khatereh Sepanjnia et al.   NEUROPSYCHOPHARMACOLOGY

Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?

(2012) Patricia J. Allen   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Putative neuroprotective agents in neuropsychiatric disorders

(2012) Seetal Dodd et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Does pioglitazone improve depression through insulin-sensitization? Results of a randomized double-blind metformin-controlled trial in patients with polycystic ovarian syndrome and comorbid depression

(2012) Ladan Kashani et al.   PSYCHONEUROENDOCRINOLOGY

A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy among Depressed Outpatients with Inadequate Response to Prior Antidepressant Therapy (ADAPT-A Study)

(2012) Maurizio Fava et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Nowhere Patients

(2012) Elena Tomba   PSYCHOTHERAPY AND PSYCHOSOMATICS

The Efficacy of Pramipexole, a Dopamine Receptor Agonist, as an Adjunctive Treatment in Treatment-Resistant Depression: An Open-Label Trial

(2012) Hiroaki Hori et al.   TheScientificWorldJOURNAL

Opioid receptors: distinct roles in mood disorders

(2012) Pierre-Eric Lutz et al.   TRENDS IN NEUROSCIENCES

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

(2012) Michael Maes et al.   INFLAMMOPHARMACOLOGY

A Consensus Statement for Safety Monitoring Guidelines of Treatments for Major Depressive Disorder

(2011) Seetal Dodd et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

The Efficacy and Tolerability of Bupropion in the Treatment of Major Depressive Disorder

(2011) Ricardo Moreira   CLINICAL DRUG INVESTIGATION

Open-label adjunctive creatine for female adolescents with SSRI-resistant major depressive disorder: A 31-phosphorus magnetic resonance spectroscopy study

(2011) Douglas G. Kondo et al.   JOURNAL OF AFFECTIVE DISORDERS

Staging methods for treatment resistant depression. A systematic review

(2011) Henricus G. Ruhé et al.   JOURNAL OF AFFECTIVE DISORDERS

Efficacy of Dose Increase Among Nonresponders to Low-Dose Aripiprazole Augmentation in Patients With Inadequate Response to Antidepressant Treatment:

(2011) David Mischoulon et al.   JOURNAL OF CLINICAL PSYCHIATRY

A Double-Blind Placebo-Controlled Trial of Lamotrigine as an Antidepressant Augmentation Agent in Treatment-Refractory Unipolar Depression

(2011) James G. Barbee et al.   JOURNAL OF CLINICAL PSYCHIATRY

Towards a glutamate hypothesis of depression

(2011) Gerard Sanacora et al.   NEUROPHARMACOLOGY

Review of Pharmacological Treatment in Mood Disorders and Future Directions for Drug Development

(2011) Xiaohua Li et al.   NEUROPSYCHOPHARMACOLOGY

Citalopram versus desipramine in treatment resistant depression: Effect of continuation or switching strategies. A randomized open study

(2011) Daniel Souery et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

S-Adenosyl Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind, Randomized Clinical Trial

(2010) George I. Papakostas et al.   AMERICAN JOURNAL OF PSYCHIATRY

Replication of Scopolamine's Antidepressant Efficacy in Major Depressive Disorder: A Randomized, Placebo-Controlled Clinical Trial

(2010) Wayne C. Drevets et al.   BIOLOGICAL PSYCHIATRY

If at First You Donʼt Succeed

(2010) K. Ryan Connolly et al.   DRUGS

Extended-release quetiapine fumarate (quetiapine XR) as adjunctive therapy in major depressive disorder (MDD) in patients with an inadequate response to ongoing antidepressant treatment: a multicentre, randomized, double-blind, placebo-controlled study

(2010) Nizar El-Khalili et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Examination of the Utility of Psychotherapy for Patients with Treatment Resistant Depression: A Systematic Review

(2010) Ranak B. Trivedi et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Lithium’s Emerging Role in the Treatment of Refractory Major Depressive Episodes: Augmentation of Antidepressants

(2010) Michael Bauer et al.   NEUROPSYCHOBIOLOGY

Pramipexole for stage 2 treatment-resistant major depression: An open study

(2010) Takeshi Inoue et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Nicotinic acetylcholine receptors and depression: a review of the preclinical and clinical literature

(2010) Noah S. Philip et al.   PSYCHOPHARMACOLOGY

Clinical practice recommendations for depression

(2009) G. S. Malhi et al.   ACTA PSYCHIATRICA SCANDINAVICA

Atypical Antipsychotic Augmentation in Major Depressive Disorder: A Meta-Analysis of Placebo-Controlled Randomized Trials

(2009) J. Craig Nelson et al.   AMERICAN JOURNAL OF PSYCHIATRY

New-Generation Antidepressants, Suicide and Depressed Adolescents: How Should Clinicians Respond to Changing Evidence?

(2009) Michael Dudley et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

The effect of venlafaxine compared with other antidepressants and placebo in the treatment of major depression

(2009) Michael Bauer et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients

(2009) Piotr Gałecki et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Venlafaxine extended release versus citalopram in patients with depression unresponsive to a selective serotonin reuptake inhibitor

(2009) Alan J. Lenox-Smith et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial

(2009) Sanjay J. Mathew et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Effects of aripiprazole adjunctive to standard antidepressant treatment on the core symptoms of depression: A post-hoc, pooled analysis of two large, placebo-controlled studies

(2009) J. Craig Nelson et al.   JOURNAL OF AFFECTIVE DISORDERS

Adjunctive Aripiprazole in Major Depressive Disorder

(2009) Madhukar H. Trivedi et al.   JOURNAL OF CLINICAL PSYCHIATRY

Efficacy of Risperidone Augmentation to Antidepressants in the Management of Suicidality in Major Depressive Disorder

(2009) Hollis Reeves et al.   JOURNAL OF CLINICAL PSYCHIATRY

Osmotic-Release Oral System Methylphenidate Augmentation of Antidepressant Monotherapy in Major Depressive Disorder

(2009) Arun V. Ravindran et al.   JOURNAL OF CLINICAL PSYCHIATRY

Extended-Release Quetiapine as Adjunct to an Antidepressant in Patients With Major Depressive Disorder

(2009) Michael Bauer et al.   JOURNAL OF CLINICAL PSYCHIATRY

An Integrated Analysis of Olanzapine/Fluoxetine Combination in Clinical Trials of Treatment-Resistant Depression

(2009) Madhukar H. Trivedi et al.   JOURNAL OF CLINICAL PSYCHIATRY

The Efficacy and Safety of Aripiprazole as Adjunctive Therapy in Major Depressive Disorder

(2009) Ronald N. Marcus et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Adaptation of Dialectical Behavior Therapy Skills Training Group for Treatment-Resistant Depression

(2009) Rebecca Harley et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders

(2009) Rodrigo Machado-Vieira et al.   NEUROSCIENTIST

What Did STAR*D Teach Us? Results From a Large-Scale, Practical, Clinical Trial for Patients With Depression

(2009) Bradley Gaynes et al.   PSYCHIATRIC SERVICES

Difference in Treatment Outcome in Outpatients With Anxious Versus Nonanxious Depression: A STAR*D Report

(2008) Maurizio Fava et al.   AMERICAN JOURNAL OF PSYCHIATRY

Brain Bioenergetics and Response to Triiodothyronine Augmentation in Major Depressive Disorder

(2008) Dan V. Iosifescu et al.   BIOLOGICAL PSYCHIATRY

Augmentation strategies for treatment-resistant depression

(2008) André F Carvalho et al.   CURRENT OPINION IN PSYCHIATRY

Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD

(2008) George I. Papakostas et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Nicotinic Antagonist Augmentation of Selective Serotonin Reuptake Inhibitor-Refractory Major Depressive Disorder

(2008) Tony P. George et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

An Open Pilot Study of the Combination of Escitalopram and Bupropion-SR for Outpatients with Major Depressive Disorder

(2008) ANDREW F. LEUCHTER et al.   Journal of Psychiatric Practice

A randomized, placebo-controlled trial of risperidone augmentation for patients with difficult-to-treat unipolar, non-psychotic major depression

(2008) Gabor I. Keitner et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The pharmacokinetics of standard antidepressants with aripiprazole as adjunctive therapy: studies in healthy subjects and in patients with major depressive disorder

(2008) DW Boulton et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Pindolol augmentation of serotonin reuptake inhibitors for the treatment of depressive disorder: a systematic review

(2008) R. Whale et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Treatment of SSRI-Resistant Depression: A Meta-Analysis Comparing Within- Versus Across-Class Switches

(2007) George I. Papakostas et al.   BIOLOGICAL PSYCHIATRY

Paroxetine with pindolol augmentation: A double-blind, randomized, placebo-controlled study in depressed in-patients

(2007) Christian Geretsegger et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY