Article
Psychiatry
David P. Herzog, Stefanie Wagner, Jan Engelmann, Giulia Treccani, Nadine Dreimueller, Marianne B. Mueller, Andre Tadic, Harald Murck, Klaus Lieb
Summary: Major depressive disorder is a highly heterogeneous disorder, with onset of depression serving as a possible clinical marker for therapy response prediction. Patients with early onset depression have more severe symptoms and worse treatment outcomes, while patients with late onset respond faster to treatment. Early non-improvement in depression after 2 weeks of therapy is associated with a higher likelihood of non-remission in early onset patients. These findings suggest the need for individualized treatment approaches based on differences in autonomic regulation for different onset groups.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Elis Bartecku, Jana Horinkova, Pavel Krenek, Alena Damborska, Josef Tomandl, Marie Tomandlov, Jan Kucera, Jana Fialova Kucerova, Julie Bienertova-Vasku
Summary: This study aimed to assess the relationship between osteocalcin and depressive symptoms. The results showed that during the first 6 weeks of treatment, osteocalcin levels decreased significantly and were associated with a reduction in depressive symptom severity. This suggests that osteocalcin may be a potential biomarker of antidepressive treatment response.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
J. Lumikukka Socada, John J. Soderholm, Tom Rosenstrom, Jesper Ekelund, Erkki Isometsa
Summary: This study investigated the prevalence, severity, co-occurrence, and overlap of manic symptoms and borderline personality features in unipolar and bipolar major depressive episodes. The results showed that the presence of mixed and borderline features in MDEs is common, with differences in diagnosis-specific features among different subcohorts. The study highlighted the impact of hypomania on perceived BPD features and the correlation between manic symptoms and borderline features.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Cecile Rep, Hugo Peyre, Marina Sanchez-Rico, Carlos Blanco, Marie Dosquet, Jean-Pierre Schuster, Frederic Limosin, Nicolas Hoertel
Summary: This study found significant age differences in risk factors for the onset of major depression. Patients with first onset before 18 years were more strongly associated with childhood maltreatment and family history of psychiatric disorders, while those first onset at 60 years and older were more strongly associated with widowhood and a history of generalized anxiety disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Franziska Konvalin, Fabienne Grosse-Wentrup, Tabea Nenov-Matt, Kai Fischer, Barbara B. Barton, Stephan Goerigk, Eva-Lotta Brakemeier, Richard Musil, Andrea Jobst, Frank Padberg, Matthias A. Reinhard
Summary: This study investigated BPD features in PDD patients and their relevance for CBASP treatment outcomes. It found that BPD symptoms are common in PDD patients and closely related to depressive symptoms. Baseline BPD features did not limit clinical response to CBASP, but may be associated with post-treatment BDI-II scores.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Yanling Zhou, Zhipei Zhang, ChengYu Wang, Xiaofeng Lan, Weicheng Li, Muqin Zhang, Guohui Lao, Kai Wu, Jun Chen, Guixiang Li, Yuping Ning
Summary: This study aimed to identify predictors of acute antidepressant efficacy in patients with first-episode Major Depressive Disorder (MDD). The study found that besides baseline clinical symptoms, cognitive function and global functioning could also be predictors of treatment outcome in first episode MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Computer Science, Information Systems
Fatemeh Hasanzadeh, Maryam Mohebbi, Reza Rostami
Summary: The concept of single-channel EEG (SCEEG) was developed for the prediction of responders and nonresponders to repetitive transcranial magnetic stimulation treatment in major depressive disorder patients. Results showed that SCEEG could effectively predict the outcome of rTMS treatment, demonstrating its high potential as a predictive method in MDD patients.
Article
Clinical Neurology
Zhou Wu, Chun Wang, Yingliang Dai, Chaoyong Xiao, Ning Zhang, Yuan Zhong
Summary: The study found that cognitive behavioral therapy plays a significant role in the treatment of major depressive disorder by improving brain connectivity between the dorsolateral prefrontal cortex (dlPFC) and hippocampus. Further research on the pathophysiology of the dlPFC is needed to better understand these abnormalities in patients with depressive symptoms and the effect of early CBT treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Clinical Neurology
Alessandro Ceresa, Cecilia Maria Esposito, Massimiliano Buoli
Summary: When BPD coexists with MDD, treatment response is generally poorer, making clinical management challenging. The combination of SSRI and psychotherapy may be an effective treatment option, with further research needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Johannes Wolf, Frank Padberg, Tabea Nenov-Matt, Benedikt L. Amann, Barbara B. Barton, Jeni Tang, Gloria Glessner, Eva-Lotta Brakemeier, Andrea Jobst, Richard Musil, Matthias A. Reinhard
Summary: Suicidal ideation and behavior are common in persistent depressive disorder and may be related to interpersonal dysfunction. This study found that in PDD, suicidal behavior is associated with loneliness, but not in BPD. Cognitive behavioral analysis system of psychotherapy shows positive effects in reducing suicidal behavior in PDD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Baolin Wu, Ying Chen, Xipeng Long, Yuan Cao, Hongsheng Xie, Xiuli Wang, Neil Roberts, Qiyong Gong, Zhiyun Jia
Summary: This study found disrupted topological organization of gray matter structural networks in adolescents with major depressive disorder (MDD), with lower cluster coefficient and local efficiency compared to healthy controls. Abnormal nodal centralities were observed in various brain regions, including the prefrontal-subcortical-limbic areas and visual cortex regions. These findings suggest the importance of impaired local segregation and abnormal nodal centralities in understanding the neurobiology of adolescent-onset MDD.
PSYCHIATRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Caitlin C. Clements, Robert Karlsson, Yi Lu, Anders Jureus, Christian Ruck, Evelyn Andersson, Julia Boberg, Nancy L. Pedersen, Cynthia M. Bulik, Axel Nordenskjold, Erik Palsson, Patrick F. Sullivan, Mikael Landen
Summary: Analysis of severe cases of major depressive disorder (MDD) using genome-wide SNP genotyping revealed a higher burden of genetic risk loci, stronger genetic correlations with other psychiatric disorders, and weaker correlations with personality and stress-related traits, suggesting a different genetic architecture at the severe end of the MDD spectrum.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Le Li, Yun-Ai Su, Yan-Kun Wu, Francisco Xavier Castellanos, Ke Li, Ji-Tao Li, Tian-Mei Si, Chao-Gan Yan
Summary: This study found significant intrinsic functional connectivity decreases in extensive brain networks after antidepressant treatment, indicating considerable antidepressant effects. There were no significant differences in resting-state functional connectivity between treatment-naive MDD patients and healthy controls.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Hehua Li, Yuanyuan Huang, Xiaocui Zang, Zhimin Zhu, Mingzhe Yang, Xiao E. Lang, Kai Wu, Fengchun Wu, Xiang Yang Zhang
Summary: Differences in severity of depression, thyroid function, and blood pressure were found between major depressive disorder patients with different ages of onset, and thyroid stimulating hormone is associated with overweight in both groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Microbiology
Yaping Wang, Jingjing Zhou, Junbin Ye, Zuoli Sun, Yi He, Yingxin Zhao, Siyu Ren, Guofu Zhang, Min Liu, Peng Zheng, Gang Wang, Jian Yang
Summary: This study reveals that antidepressants can improve abnormal blood metabolism and have a weak inhibitory effect on the gut microbiota. The gut microbiota is associated with changes in plasma metabolites and clinical remission in patients with major depressive disorder (MDD). Furthermore, the presence of sporulation genes can predict the efficacy of antidepressant treatment.
Article
Psychology, Clinical
Kimie Stefanie Ormstrup Sletved, Simon Christoffer Ziersen, Per Kragh Andersen, Maj Vinberg, Lars Vedel Kessing
Summary: This study, based on Danish register data, found that patients with bipolar disorder and their relatives have poorer socio-economic functioning compared to the general population, and this does not improve over a long-term follow-up period.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Hanne Lie Kjaerstad, Julian Macoveanu, Gitte Moos Knudsen, Sophia Frangou, K. Luan Phan, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: This study compared the neural responses during voluntary down-regulation of negative emotions in bipolar disorder patients, their unaffected first-degree relatives, and healthy controls. The results showed hypo-activity in the prefrontal cortex and deficient connectivity between the prefrontal cortex and amygdala in patients and their relatives, indicating impaired emotion regulation. This study highlights the importance of understanding aberrant emotion regulation in bipolar disorder.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Immunology
Klara Coello, Julie Lyng Forman, Helle Holstad Pedersen, Maj Vinberg, Henrik Enghusen Poulsen, Lars V. Kessing
Summary: This study found that patients with bipolar disorder (BD) and their unaffected first-degree relatives have higher levels of oxidative stress generated RNA damage compared to healthy control individuals, while DNA damage showed less consistent elevation. This suggests that oxidative stress generated RNA damage may be related to the pathophysiology of BD.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Psychiatry
A. Ratheesh, D. Hett, J. Ramain, E. Wong, L. Berk, P. Conus, M. A. Fristad, T. Goldstein, M. Hillegers, S. Jauhar, L. Kessing, D. J. Miklowitz, G. Murray, J. Scott, M. Tohen, L. N. Yatham, A. H. Young, M. Berk, S. Marwaha
Summary: This systematic review examined the effectiveness of interventions in the early course of bipolar disorder (BD). The findings suggested that lithium use was associated with lower recurrence risk compared to other mood stabilizers, and mood stabilizers were associated with better global functioning compared to antipsychotics in the medium term. Psychological interventions, such as family-focused and cognitive-behavioral interventions, were associated with reduced recurrence risk or improved symptomatic outcomes. Pharmacological interventions were more efficacious when utilized in the earlier stages of illness.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Aske L. Ejdrup, Joel Wellbourne-Wood, Jakob K. Dreyer, Nina Guldhammer, Matthew D. Lycas, Ulrik Gether, Benjamin J. Hall, Gunnar Sorensen
Summary: A fundamental concept in neuroscience is the transmission of information between neurons via neurotransmitters, modulators, and peptides. The gold standard for measuring neurochemicals in awake animals has been microdialysis (MD), but genetically encoded fluorescence-based biosensors and in vivo optical techniques have introduced technologically distinct means of measuring neurotransmission. Comparing MD and fiber photometry (FP), the study found that although there were temporal differences, the readouts of extracellular dopamine (DA) correlated well within mice. Down-sampling of FP data showed temporal correlation to MD, with less variance observed using FP. The study also discovered periodic low levels of DA fluctuations and rapid predrug DA dynamics measured with FP that correlated to the subsequent pharmacodynamics of amphetamine as measured with MD and FP.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Hanne Lie Kjaerstad, Thea Haldorsen, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: This study found that impairments in both emotional and non-emotional cognition are associated with bipolar disorder (BD). There is a lack of research investigating cognitive predictors of prognosis in BD patients. The study showed that cognitive performance at baseline is associated with recurrence and duration of (hypo)manic and depressive episodes in patients with BD over a 16-month follow-up period. Therefore, early prophylactic strategies targeting cognitive impairments may improve the resilience and course of illness in recently diagnosed patients with BD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Kimie Stefanie Ormstrup Sletved, Niels Henrik Falck Villemoes, Klara Coello, Sharleny Stanislaus, Hanne Lie Kjaerstad, Maria Faurholt-Jepsen, Kamilla Miskowiak, Jens Drachmann Bukh, Maj Vinberg, Lars Vedel Kessing
Summary: This study investigated the prevalence of comorbid personality disorders in patients with newly diagnosed BD and their unaffected first-degree relatives compared with healthy control individuals. The results showed that 25.5% of patients with newly diagnosed BD and 6.4% of their relatives fulfilled the criteria for comorbid personality disorders. Subthreshold personality disorders were also more prevalent in BD patients and their relatives. Comorbid personality disorders were associated with impaired functioning in BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Talip E. Eroglu, Ruben Coronel, Andrim Halili, Lars Vedel Kessing, Anojhaan Arulmurugananthavadivel, Saaima Parveen, Fredrik Folke, Christian Torp-Pedersen, Gunnar H. Gislason
Summary: Long-term stress (post-traumatic stress disorder, adjustment disorder) or anxiety is associated with an increased risk of out-of-hospital cardiac arrest (OHCA). This association applies to both men and women, and is independent from the presence of cardiovascular disease. Awareness of this association is crucial when treating patients with stress-related disorders and anxiety.
Article
Clinical Neurology
Maria Faurholt-Jepsen, Jonas Busk, Jakob Eyvind Bardram, Sharleny Stanislaus, Mads Frost, Ellen Margrethe Christensen, Maj Vinberg, Lars Vedel Kessing
Summary: This study found a positive association between mood instability and activity/energy instability in patients with bipolar disorder. These instabilities were also associated with stress, quality of life, and functioning. The findings highlight the importance of monitoring and identifying inter-episodic fluctuations in symptoms for clinical management.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Kamilla W. Miskowiak, Anja H. Simonsen, Morten Meyer, Henrik Enghusen Poulsen, Mira Wilkan, Julie Forman, Steen G. Hasselbalch, Lars V. Kessing, Ulla Knorr
Summary: This study aimed to investigate the association of brain erythropoietin (EPO) and oxidative stress with cognitive functions in bipolar disorder (BD) patients, as well as the changes in brain EPO during and after affective episodes. The results showed that verbal memory decreased with increasing concentrations of EPO and oxidative stress, but these associations were not significant after adjusting for multiple testing.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
K. W. Miskowiak, H. L. Kjaestad, C. K. Lemvigh, K. S. Ambrosen, M. S. Thorvald, L. V. Kessing, B. Y. Glenthoj, B. H. Ebdrup, B. Fagerlund
Summary: This study aimed to investigate whether there are common neurocognitive subgroups in patients with schizophrenia and bipolar disorder during early stages of illness. The results showed that patients could be classified into three subgroups, including a cognitively intact subgroup, a subgroup with selective deficits, and a subgroup with global impairments. These subgroups were not related to clinical symptoms or medications, suggesting potential neurodevelopmental origins.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Anne Sofie Aggestrup, Signe Dunker Svendsen, Anne Praestegaard, Philip Loventoft, Lasse Norregaard, Ulla Knorr, Henrik Dam, Erik Frokjaer, Konstantin Danilenko, Ida Hageman, Maria Faurholt-Jepsen, Lars Vedel Kessing, Klaus Martiny
Summary: CRT intervention with electronic self-monitoring system can effectively prevent worsening of depression after discharge, improve sleep quality, and stabilize mood for patients with major depression.
JMIR MENTAL HEALTH
(2023)
Article
Medicine, General & Internal
Helle Ostergaard Madsen, Ida Hageman, Klaus Martiny, Maria Faurholt-Jepsen, Miriam Kolko, Tone E. G. Henriksen, Lars Vedel Kessing
Summary: This study aims to evaluate the acute and long-term stabilizing effects of blue blocking glasses in the outpatient treatment of bipolar disorder. Patients will be randomly assigned to wear glasses with high or low filtration of short wavelength light, and the treatment effects will be observed through continuous assessments and self-monitoring.
ANNALS OF MEDICINE
(2023)
Article
Psychiatry
Anders Jorgensen, Emma Neble Larsen, Mathilde Marie Bruennich Sloth, Lars Vedel Kessing, Merete Osler
Summary: This study investigates the prescription patterns of antidepressant medications in a large cohort of patients with unipolar depression. The findings reveal the potential for improving clinical care for these patients through optimization of the use of marketed antidepressants. However, the prescribing patterns often do not align with guidelines and treatment strategies frequently change regardless of depression severity.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Psychiatry
Lars Vedel Kessing, Simon Christoffer Ziersen, Avshalom Caspi, Terrie E. Moffitt, Per Kragh Andersen
Summary: This study investigates the lifetime incidence of mental health disorders and the association with long-term socioeconomic difficulties in the Danish population. The findings show that the majority of individuals either received a diagnosis of a mental health disorder or were prescribed psychotropic medication during their lifetime, which was associated with subsequent socioeconomic difficulties.
