Article
Clinical Neurology
Gernot Fugger, Lucie Bartova, Chiara Fabbri, Giuseppe Fanelli, Raffaella Zanardi, Markus Dold, Alexander Kautzky, Dan Rujescu, Daniel Souery, Julien Mendlewicz, Joseph Zohar, Stuart Montgomery, Alessandro Serretti, Siegfried Kasper
Summary: A study found that European patients who were prescribed NaSSAs as first-line antidepressant treatment had characteristics such as older age, male gender, unemployment, additional melancholic and catatonic features, inpatient treatment, lower dosages of antidepressants but higher rates of augmentation with low-potency antipsychotics, and greater reductions of depressive symptoms during their current major depressive episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
E. Loeb, K. El Asmar, S. Trabado, F. Gressier, R. Colle, A. Rigal, S. Martin, C. Verstuyft, B. Feve, P. Chanson, L. Becquemont, E. Corruble
Summary: This study found that depressed patients have decreased NOS activity compared to healthy controls, and it improves after antidepressant treatment. NOS activity may be a promising biomarker for major depressive episodes in the context of major depressive disorder.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Tiffany C. Ho, Boris Gutman, Elena Pozzi, Hans J. Grabe, Norbert Hosten, Katharina Wittfeld, Henry Voelzke, Bernhard Baune, Udo Dannlowski, Katharina Foerster, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Tilo Kircher, Axel Krug, Susanne Meinert, Igor Nenadic, Nils Opel, Richard Dinga, Dick J. Veltman, Knut Schnell, Ilya Veer, Henrik Walter, Ian H. Gotlib, Matthew D. Sacchet, Andre Aleman, Nynke A. Groenewold, Dan J. Stein, Meng Li, Martin Walter, Christopher R. K. Ching, Neda Jahanshad, Anjanibhargavi Ragothaman, Dmitry Isaev, Artemis Zavaliangos-Petropulu, Paul M. Thompson, Philipp G. Saemann, Lianne Schmaal
Summary: This study investigated the differences in subcortical shape between patients with major depressive disorder (MDD) and healthy controls. The results showed that both adolescent-onset MDD and recurrent MDD patients had lower thickness and surface area in certain subcortical regions compared to healthy controls.
HUMAN BRAIN MAPPING
(2022)
Review
Clinical Neurology
Xipeng Long, Lei Li, Xiuli Wang, Yuan Cao, Baolin Wu, Neil Roberts, Qiyong Gong, Graham J. Kemp, Zhiyun Jia
Summary: This study conducted a comprehensive meta-analysis of gray matter volume alterations in adolescents with major depressive disorder and bipolar disorder. The findings suggest that distinct patterns of GMV alterations in these two populations could aid in differentiation and provide potential diagnostic biomarkers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Mayron Piccolo, Emily L. Belleau, Laura M. Holsen, Madhukar H. Trivedi, Ramin V. Parsey, Patrick J. McGrath, Myrna M. Weissman, Diego A. Pizzagalli, Kristin N. Javaras
Summary: This study found that hyperphagic MDD may be associated with altered activity and connectivity between interoceptive and reward regions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Yang Yang, Qian Cui, Fengmei Lu, Yajing Pang, Yuyan Chen, Qin Tang, Di Li, Ting Lei, Zongling He, Shan Hu, Jiaxin Deng, Huafu Chen
Summary: The study revealed abnormal functional connectivity patterns of DMN subsystems in patients with bipolar disorder during major depressive episodes, and these abnormalities were associated with high levels of pessimism, highlighting the importance of pathological mechanisms in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Tomiki Sumiyoshi, Tatsuya Hoshino, Izumi Mishiro, Lene Hammer-Helmich, Holly Ge, Yoshiya Moriguchi, Keita Fujikawa, Jovelle L. Fernandez
Summary: Early improvement in depressive symptoms predicts better cognitive outcomes in patients with Major Depressive Disorder (MDD). Grouping patients by mood and cognition status in early stages of antidepressant treatments may help improve long-term functional outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neuroimaging
Congcong Liu, Jing Dai, Yuanshu Chen, Ziyu Qi, Fei Xin, Qian Zhuang, Xinqi Zhou, Feng Zhou, Lizhu Luo, Yulan Huang, Jinyu Wang, Zhili Zou, Huafu Chen, Keith M. Kendrick, Bo Zhou, Xiaolei Xu, Benjamin Becker
Summary: The study found specific inhibitory control dysregulations in major depressive disorder patients at both behavioral and neural levels, while generalized anxiety disorder patients exhibited different brain region activities during inhibitory control. These findings may contribute to a better understanding of the neuropathological and diagnostic markers specific to depression.
NEUROIMAGE-CLINICAL
(2021)
Article
Psychiatry
Qi Zhou, Xiaozhen Lv, Shuzhe Zhou, Qi Liu, Hongjun Tian, Kerang Zhang, Jing Wei, Gang Wang, Qiaoling Chen, Gang Zhu, Xueyi Wang, Cuixia An, Nan Zhang, Yu Huang, Tianmei Si, Xin Yu, Chuan Shi
Summary: Inflammation and cognition are related to major depressive disorder (MDD). Treatment response in MDD patients is associated with different cognitive defects, especially in speed of processing and executive function. Factors such as smoking, alcohol drinking, baseline cognitive performance, and cytokine levels may influence treatment response.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Huifeng Zhang, Zhiguo Wu, Lan Cao, Yousong Su, Fan Wang, Wu Hong, Yiyun Cai, Daihui Peng, Yiru Fang
Summary: Despite numerous treatment options for major depressive disorder (MDD), the efficacy of treatment remains uncertain. Algorithm-guided treatments (AGTs) are proposed to address this issue. This study evaluated the clinical benefit of AGTs for MDD and identified specific moderators that influence treatment outcomes. AGTs were found to have advantages in quality of life and relapse rates compared to treatment-as-usual (TAU), with disease episode types and somatic symptoms playing a significant role in treatment outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Engineering, Biomedical
Yueheng Peng, Yang Huang, Baodan Chen, Mengling He, Lin Jiang, Yuqin Li, Xunan Huang, Changfu Pei, Shu Zhang, Cunbo Li, Xiabing Zhang, Tao Zhang, Yutong Zheng, Dezhong Yao, Fali Li, Peng Xu
Summary: This study analyzed resting-state electroencephalogram (EEG) data from patients with major depressive disorder (MDD) and found that the corresponding EEG networks weakened significantly after short-term antidepressant treatment. This change in network properties within one week of medication reliably predicted the eventual medication efficacy. Additionally, the baseline EEG networks accurately distinguished responders from non-responders with a high accuracy.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Article
Clinical Neurology
Hyeyoung Kim, Kyu-Man Han, Kwan Woo Choi, Woo-Suk Tae, Wooyoung Kang, Youbin Kang, Aram Kim, Byung-Joo Ham
Summary: The study examined the volume differences in each amygdala subregion in adults with and without MDD, using automatic segmentation of the nine nuclei of the amygdala. Patients with MDD showed significantly lower volumes in the entire amygdala and subregions compared to healthy volunteers, with no significant associations with antidepressant use, illness duration, or depression severity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Nutrition & Dietetics
Ping Lin, Dan Li, Yun Shi, Qingtian Li, Xiaokui Guo, Ke Dong, Qing Chen, Xiaoyan Lou, Zhenhua Li, Ping Li, Weifeng Jin, Shuzi Chen, Yang Sun, Jing Sun, Xunjia Cheng
Summary: Studies have shown that the gut microbiota is associated with neurological and psychiatric diseases. However, the changes in gut microbiota in patients with major depressive disorder (MDD) and their association with disease mechanisms are still unclear. This study recruited MDD patients and healthy controls, analyzed the compositional characteristics of the gut microbiota in MDD patients, and detected specific markers in their plasma. The results showed significant changes in the diversity and relative abundance of the gut microbiota in MDD patients, suggesting that these changes may potentially serve as biomarkers for MDD.
Article
Clinical Neurology
Lei Wang, Qing Ma, Xiaoyi Sun, Zhilei Xu, Jiaying Zhang, Xuhong Liao, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia, Yihe Zhang
Summary: This study conducted frequency-resolved connectome analysis on a large sample of MDD patients and healthy controls, revealing significant frequency-dependent connectome alterations in MDD. These alterations mainly occur in the left parietal, temporal, precentral, and fusiform cortices, as well as bilateral precuneus. Additionally, the connectome alteration in the high frequency band (0.16-0.24 Hz) is significantly associated with illness duration.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Hannah Lemke, Lina Romankiewicz, Katharina Foerster, Susanne Meinert, Lena Waltemate, Stella M. Fingas, Dominik Grotegerd, Ronny Redlich, Katharina Dohm, Elisabeth J. Leehr, Katharina Thiel, Verena Enneking, Katharina Brosch, Tina Meller, Kai Ringwald, Simon Schmitt, Frederike Stein, Olaf Steinstraeter, Jochen Bauer, Walter Heindel, Andreas Jansen, Axel Krug, Igor Nenadic, Tilo Kircher, Udo Dannlowski
Summary: This study investigates the association between disease course in Major Depressive Disorder (MDD) and brain structural alterations. The results suggest that a more severe and chronic disease course in MDD is associated with reduced volume in brain regions relevant for executive and cognitive functions and emotion regulation.
DEPRESSION AND ANXIETY
(2022)
Editorial Material
Psychiatry
Victor I. Reus, Laura J. Fochtmann, Oscar Bukstein, A. Evan Eyler, Donald M. Hilty, Marcela Horvitz-Lennon, Jane Mahoney, Jagoda Pasic, Michael Weaver, Cheryl D. Wills, Jack McIntyre, Jeremy Kidd, Joel Yager, Seung-Hee Hong
AMERICAN JOURNAL OF PSYCHIATRY
(2018)
Meeting Abstract
Neurosciences
Daniel Lindqvist, Owen Wolkowitz, Martin Picard, Lars Ohlsson, Francesco Saverio Bersani, Johan Fernstrom, Asa Westrin, Christina Hough, Jue Lin, Cecile Grudet, Lennart Ljunggren, Lil Traskman-Bendz, Victor Reus, Elissa Epel, Synthia H. Mellon
BIOLOGICAL PSYCHIATRY
(2018)
Article
Clinical Neurology
Olga Tymofiyeva, Eva Henje Blom, Tiffany C. Ho, Colm G. Connolly, Daniel Lindqvist, Owen M. Wolkowitz, Jue Lin, Kaja Z. LeWinn, Matthew D. Sacchet, Laura K. M. Han, Justin P. Yuan, Sarina P. Bhandari, Duan Xu, Tony T. Yang
JOURNAL OF AFFECTIVE DISORDERS
(2018)
Article
Surgery
Shipra Arya, Sujin Lee, Greg J. Zahner, Beth E. Cohen, Jade Hiramoto, Owen M. Wolkowitz, Anjali Khakharia, Zachary O. Binney, S. Marlene Grenon
JOURNAL OF VASCULAR SURGERY
(2018)
Article
Neurosciences
Daniel Lindqvist, Owen M. Wolkowitz, Martin Picard, Lars Ohlsson, Francesco S. Bersani, Johan Fernstrom, Asa Westrin, Christina M. Hough, Jue Lin, Victor I. Reus, Elissa S. Epel, Synthia H. Mellon
NEUROPSYCHOPHARMACOLOGY
(2018)
Editorial Material
Psychiatry
Owen M. Wolkowitz
Article
Peripheral Vascular Disease
Natalie V. M. Hernandez, Joel L. Ramirez, Sukaynah A. Khetani, Kimberly A. Spaulding, Warren J. Gasper, Jade Hiramoto, Daniel Lindqvist, Owen M. Wolkowitz, Nancy K. Hills, S. Marlene Grenon, Greg J. Zahner
Article
Psychiatry
Maryam S. Khan, Gwyneth W. Y. Wu, Victor I. Reus, Christina M. Hough, Daniel Lindqvist, Asa Westrin, Brenton M. Nier, Owen M. Wolkowitz, Synthia H. Mellon
PSYCHIATRY RESEARCH
(2019)
Article
Clinical Neurology
Amanda Holck, Owen M. Wolkowitz, Sindy H. Mellon, Victor Reus, J. Craig Nelson, Asa Westrina, Daniel Lindqvist
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Endocrinology & Metabolism
Laura K. M. Han, Josine E. Verhoeven, Audrey R. Tyrka, Brenda W. J. H. Penninx, Owen M. Wolkowitz, Kristoffer N. T. Mansson, Daniel Lindqvist, Marco P. Boks, Dora Revesz, Synthia H. Mellon, Martin Picard
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Felipe A. Jain, Coim G. Connolly, Victor I. Reus, Dieter J. Meyerhoff, Tony T. Yang, Synthia H. Mellon, Scott Mackin, Christina M. Hough, Alexandra Morford, Owen M. Wolkowitz
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Edward J. Goetzl, Owen M. Wolkowitz, Vinod H. Srihari, Victor Reus, Laura Goetzl, Dimitrios Kapogiannis, George R. Heninger, Synthia H. Mellon
Summary: Neuronal mitochondrial abnormalities were characterized in major depressive disorder by quantifying functional mitochondrial proteins extracted from enriched plasma neuron-derived extracellular vesicles. Baseline levels of various mitochondrial proteins were found to be significantly different in MDD participants compared to controls, with some showing normalization in participants who responded to SSRI therapy. These findings suggest potential biomarkers for MDD and new drug targets.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Johan Fernstrom, Synthia H. Mellon, Marlon A. McGill, Martin Picard, Victor Reus, Christina M. Hough, Jue Lin, Elissa S. Epel, Owen M. Wolkowitz, Daniel Lindqvist
Summary: The study found that mitochondrial markers did not differentiate between individuals with major depressive disorder and healthy controls, but could distinguish between SSRI responders and nonresponders. Mitochondrial dysfunction may be implicated in treatment response to SSRI in MDD.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Psychiatry
Ekaterina Protsenko, Owen M. Wolkowitz, Kristine Yaffe
Summary: Psychiatry has shown increasing interest in the concept of biological aging, and research has explored the relationship between stress, psychiatric illness, and accelerated biological aging. Epigenetic clocks, specifically the GrimAge clock, have been used to estimate biological age based on DNA methylation data. Several studies have examined the associations between stress, PTSD, MDD, and GrimAge acceleration, but the results are mixed, possibly due to variations in analytic methods and covariate selection. To address this issue, a systematic framework for covariate selection and an approach to results reporting are proposed to improve analytic consensus.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neuroimaging
Kirstin Aschbacher, Synthia H. Mellon, Owen M. Wolkowitz, Clare Henn-Haase, Rachel Yehuda, Janine D. Flory, Linda M. Bierer, Duna Abu-Amara, Charles R. Marmar, Susanne G. Mueller
BRAIN IMAGING AND BEHAVIOR
(2018)