Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses

Pyk2 Signaling through Graf1 and RhoA GTPase is Required for Amyloid-β Oligomer Triggered Synapse Loss

(2019) Suho Lee et al.   JOURNAL OF NEUROSCIENCE

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

(2019) Jean-Christophe Delpech et al.   TRENDS IN NEUROSCIENCES

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Neuroinflammation in frontotemporal dementia

(2019) Fiona Bright et al.   Nature Reviews Neurology

Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age

(2019) Aliza P. Wingo et al.   Nature Communications

Targeting the Synapse in Alzheimer’s Disease

(2019) Johanna Jackson et al.   Frontiers in Neuroscience

Emerging roles of extracellular vesicles in neurodegenerative disorders

(2019) Yang You et al.   NEUROBIOLOGY OF DISEASE

Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy

(2019) Satoshi Muraoka et al.   Frontiers in Neuroscience

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

(2018) Yuetiva Deming et al.   ACTA NEUROPATHOLOGICA

De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy

(2018) Anna Fassio et al.   BRAIN

Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD

(2018) Alexander Starr et al.   BRAIN RESEARCH

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers

(2018) James P. Quinn et al.   JOURNAL OF ALZHEIMERS DISEASE

Dynamic Scaling of Exosome Sizes

(2018) Michael Paulaitis et al.   LANGMUIR

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aldehyde dehydrogenase 2 in the spotlight: The link between mitochondria and neurodegeneration

(2018) Romina Deza-Ponzio et al.   NEUROTOXICOLOGY

The Way of Tau: Secretion and Synaptic Dysfunction

(2018) Dena B. Dubal   TRENDS IN MOLECULAR MEDICINE

Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions

(2018) Shuo-Chien Ling   NEURAL PLASTICITY

Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy

(2018) Taeko Kimura et al.   Frontiers in Neuroscience

Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

(2018) Mirta Borin et al.   Acta Neuropathologica Communications

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Plasma Fetuin-A is Associated with the Severity of Cognitive Impairment in Mild-to-Moderate Alzheimer's Disease

(2018) Edward R. Smith et al.   JOURNAL OF ALZHEIMERS DISEASE

Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration

(2018) Jian-Zhi Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

ASCT1 (Slc1a4) transporter is a physiologic regulator of brain d-serine and neurodevelopment

(2018) Eitan Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain

(2018) Shin Koike et al.   BRAIN RESEARCH BULLETIN

Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo

(2018) Charisse N. Winston et al.   JOURNAL OF ALZHEIMERS DISEASE

Do inflammatory profiles explain ALS–FTD spectrum?

(2018) Ian Fyfe   Nature Reviews Neurology

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression

(2018) Hsu-Hsin Chen et al.   Scientific Reports

Different tau species lead to heterogeneous tau pathology propagation and misfolding

(2018) Simon Dujardin et al.   Acta Neuropathologica Communications

SPARCL1 Accelerates Symptom Onset in Alzheimer’s Disease and Influences Brain Structure and Function During Aging

(2017) Sahba Seddighi et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

(2017) Ravi Rajmohan et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia

(2017) Deepti Lall et al.   JOURNAL OF CLINICAL INVESTIGATION

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

(2017) Gao-Shang Chai et al.   Molecular Neurodegeneration

Genetic risk for schizophrenia and psychosis in Alzheimer disease

(2017) M A A DeMichele-Sweet et al.   MOLECULAR PSYCHIATRY

Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation

(2017) Patrick Reilly et al.   NEUROBIOLOGY OF DISEASE

Frontotemporal dementia with the V337M MAPT mutation

(2017) Salvatore Spina et al.   NEUROLOGY

Plasma Membrane Protein Profiling in Beta-Amyloid-Treated Microglia Cell Line

(2017) Virginia Correani et al.   PROTEOMICS

Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony

(2017) Stefania Forner et al.   TRENDS IN NEUROSCIENCES

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

(2017) Maria B. Bagh et al.   Nature Communications

Tau association with synaptic vesicles causes presynaptic dysfunction

(2017) Lujia Zhou et al.   Nature Communications

Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging

(2017) Michelle M. Mielke et al.   JAMA Neurology

Exosomes in the Diseased Brain: First Insights from In vivo Studies

(2017) Efrat Levy   Frontiers in Neuroscience

Altered Distribution of RhoA in Alzheimer's Disease and AβPP Overexpressing Mice

(2017) Gema Huesa et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased Mitochondrial Aldehydedehydrogenase in the putamen of individuals with Alzheimer's disease

(2017) Tanja Maria Michel et al.   JOURNAL OF ALZHEIMERS DISEASE

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

Genetics of Frontotemporal Dementia

(2016) Diana A. Olszewska et al.   Current Neurology and Neuroscience Reports

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis

(2016) Raffaele Ferrari et al.   Molecular Neurodegeneration

Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling

(2016) Yaling Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

Study of microRNAs (miRNAs) that are predicted to target the autoantigens Ro/SSA and La/SSB in primary Sjögren's Syndrome

(2015) V. C. Gourzi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma

(2015) Hirayuki Enomoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analysis of Exosome Release as a Cellular Response to MAPK Pathway Inhibition

(2015) K. Agarwal et al.   LANGMUIR

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

One-hour proteome analysis in yeast

(2015) Alicia L Richards et al.   Nature Protocols

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer’s disease patients

(2015) Tomoko Kato et al.   NEUROSCIENCE LETTERS

Loss of tau rescues inflammation-mediated neurodegeneration

(2015) Nicole Maphis et al.   Frontiers in Neuroscience

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

(2014) Susana Boluda et al.   ACTA NEUROPATHOLOGICA

Review and Research Analysis of Computational Target Methods Using BioRuby and In silico Screening of Herbal Lead Compounds Against Pancreatic Cancer Using R Programming

(2014) Jayadeepa R.M et al.   CURRENT DRUG METABOLISM

Deficiency of GDNF Receptor GFR 1 in Alzheimer's Neurons Results in Neuronal Death

(2014) Y. Konishi et al.   JOURNAL OF NEUROSCIENCE

Normalyzer: A Tool for Rapid Evaluation of Normalization Methods for Omics Data Sets

(2014) Aakash Chawade et al.   JOURNAL OF PROTEOME RESEARCH

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Protein phosphatase 2A dysfunction in Alzheimer’s disease

(2014) Jean-Marie Sontag et al.   Frontiers in Molecular Neuroscience

Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages

(2013) Masato Mitsuhashi et al.   FASEB JOURNAL

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer’s disease

(2013) Elena Marcello et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetics of dementia

(2013) Clement T Loy et al.   LANCET

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Silencing PP2A Inhibitor by Lenti-shRNA Interference Ameliorates Neuropathologies and Memory Deficits in tg2576 Mice

(2013) Gong-Ping Liu et al.   MOLECULAR THERAPY

ADAM10 in Synaptic Physiology and Pathology

(2013) Stefano Musardo et al.   Neurodegenerative Diseases

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity

(2013) Xinxin Li et al.   NEUROSCIENCE LETTERS

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Olfactomedin 1 Interacts with the Nogo A Receptor Complex to Regulate Axon Growth

(2012) Naoki Nakaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

(2012) Andrea Franceschini et al.   NUCLEIC ACIDS RESEARCH

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury

(2011) Chun Geun Lee et al.   Annual Review of Physiology

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs

(2011) Parvathi Rudrabhatla et al.   FASEB JOURNAL

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus

(2011) Luis A. Martinez et al.   NEUROPHARMACOLOGY

Cell-Surface Marker Signatures for the Isolation of Neural Stem Cells, Glia and Neurons Derived from Human Pluripotent Stem Cells

(2011) Shauna H. Yuan et al.   PLoS One

Expression of Nestin by Neural Cells in the Adult Rat and Human Brain

(2011) Michael L. Hendrickson et al.   PLoS One

Gelsolin as therapeutic target in Alzheimer's disease

(2010) Eva Carro   EXPERT OPINION ON THERAPEUTIC TARGETS

Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

(2010) Maria Jose Metcalfe et al.   MOUNT SINAI JOURNAL OF MEDICINE

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury

(2009) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy

(2009) Mei Yue et al.   NEUROBIOLOGY OF AGING

Numb Endocytic Adapter Proteins Regulate the Transport and Processing of the Amyloid Precursor Protein in an Isoform-dependent Manner

(2008) George A. Kyriazis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Mutations in Neurodegenerative Diseases

(2008) Michael S. Wolfe   JOURNAL OF BIOLOGICAL CHEMISTRY

Gamma-Secretase-Dependent and -Independent Effects of Presenilin1 on β-Catenin·Tcf-4 Transcriptional Activity

(2008) Imma Raurell et al.   PLoS One