Exosomes in the Diseased Brain: First Insights from In vivo Studies

Evidence that the Amyloid-β Protein Precursor Intracellular Domain, AICD, Derives From β-Secretase-Generated C-Terminal Fragment

(2018) Brice Flammang et al.   JOURNAL OF ALZHEIMERS DISEASE

Sphingolipid-Enriched Extracellular Vesicles and Alzheimer’s Disease: A Decade of Research

(2017) Michael B. Dinkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease

(2016) Brian Spencer et al.   HUMAN MOLECULAR GENETICS

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice

(2016) Siân Baker et al.   JOURNAL OF ALZHEIMERS DISEASE

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

(2016) Michael B. Dinkins et al.   JOURNAL OF NEUROSCIENCE

Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR

(2016) Xavier Gallart-Palau et al.   Molecular Neurodegeneration

Traumatic brain injury increases levels of miR-21 in extracellular vesicles: implications for neuroinflammation

(2016) Emily B. Harrison et al.   FEBS Open Bio

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction

(2015) Pooja Joshi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysfunction of Platelet-derived Growth Factor Receptor α (PDGFRα) Represses the Production of Oligodendrocytes from Arylsulfatase A-deficient Multipotential Neural Precursor Cells

(2015) Katarzyna C. Pituch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass-Spectrometry-Based Molecular Characterization of Extracellular Vesicles: Lipidomics and Proteomics

(2015) Simion Kreimer et al.   JOURNAL OF PROTEOME RESEARCH

Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles

(2015) E. van der Pol et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural–glial networks

(2015) Dasiel O. Borroto-Escuela et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Correction: MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease

(2015) Sowmya V. Yelamanchili et al.   PLoS Pathogens

MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease

(2015) Sowmya V. Yelamanchili et al.   PLoS Pathogens

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Rab GTPase regulation of membrane identity

(2013) Suzanne R Pfeffer   CURRENT OPINION IN CELL BIOLOGY

More than Cell Dust: Microparticles Isolated from Cerebrospinal Fluid of Brain Injured Patients Are Messengers Carrying mRNAs, miRNAs, and Proteins

(2013) Silke Patz et al.   JOURNAL OF NEUROTRAUMA

Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients

(2013) Meredith G. Banigan et al.   PLoS One

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

Novel G S-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain

(2012) C. Deyts et al.   JOURNAL OF NEUROSCIENCE

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

(2012) Robert Tamayev et al.   Molecular Neurodegeneration

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities

(2011) JO Agola et al.   CLINICAL GENETICS

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

A filtration-based protocol to isolate human Plasma Membrane-derived Vesicles and exosomes from blood plasma

(2011) Ryan Grant et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline

(2010) May A. Beydoun et al.   NEUROBIOLOGY OF AGING

HIV and Mature Dendritic Cells: Trojan Exosomes Riding the Trojan Horse?

(2010) Nuria Izquierdo-Useros et al.   PLoS Pathogens

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Alzheimer's-related endosome dysfunction in Down syndrome is A -independent but requires APP and is reversed by BACE-1 inhibition

(2009) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme

(2008) Cristina Escrevente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Trafficking and function of the tetraspanin CD63

(2008) Maaike S. Pols et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Proteomic profiling of exosomes: Current perspectives

(2008) Richard J. Simpson et al.   PROTEOMICS

Itinerant exosomes: emerging roles in cell and tissue polarity

(2008) Aparna Lakkaraju et al.   TRENDS IN CELL BIOLOGY