Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats

Microglial regulation of satiety and cognition

(2020) Simone N. De Luca et al.   JOURNAL OF NEUROENDOCRINOLOGY

Glial remodeling enhances short-term memory performance in Wistar rats

(2020) Simone N. De Luca et al.   Journal of Neuroinflammation

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

The behavioral sequelae of social defeat require microglia and are driven by oxidative stress in mice

(2019) Michael L. Lehmann et al.   JOURNAL OF NEUROSCIENCE

Adolescent microglia play a role in executive function in male mice exposed to perinatal high fat diet

(2019) Brittany L. Smith et al.   BRAIN BEHAVIOR AND IMMUNITY

Heterogeneity of microglia and their differential roles in white matter pathology

(2019) Janice Lee et al.   CNS Neuroscience & Therapeutics

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery

(2018) Jillian C. Nissen et al.   EXPERIMENTAL NEUROLOGY

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

(2018) Xiaoxia Yang et al.   FASEB JOURNAL

Pharmacologic depletion of microglia increases viral load in the brain and enhances mortality in murine models of Flavivirus-induced encephalitis

(2018) Scott Seitz et al.   JOURNAL OF VIROLOGY

Microglia Are Critical in Host Defense against Prion Disease

(2018) James A. Carroll et al.   JOURNAL OF VIROLOGY

Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain

(2018) SeungHwan Lee et al.   Molecular Pain

Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion

(2018) Yubin Huang et al.   NATURE NEUROSCIENCE

Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase

(2018) Elisabeth G. Vichaya et al.   NEUROPSYCHOPHARMACOLOGY

Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage

(2018) Inken Waltl et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice

(2018) M. S. Unger et al.   Journal of Neuroinflammation

The Influence of Microglial Elimination and Repopulation on Stress Sensitization Induced by Repeated Social Defeat

(2018) Michael D. Weber et al.   BIOLOGICAL PSYCHIATRY

Conditional microglial depletion in rats leads to reversible anorexia and weight loss by disrupting gustatory circuitry

(2018) Simone N. De Luca et al.   BRAIN BEHAVIOR AND IMMUNITY

Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation

(2018) Kristina G. Witcher et al.   GLIA

Enforced microglial depletion and repopulation as a promising strategy for the treatment of neurological disorders

(2018) Jinming Han et al.   GLIA

Acute microglia ablation induces neurodegeneration in the somatosensory system

(2018) Stephen J. Rubino et al.   Nature Communications

Microglia ablation alleviates myelin-associated catatonic signs in mice

(2017) Hana Janova et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal

(2017) T. Jordan Walter et al.   Journal of Neuroinflammation

Microglia Are Irrelevant for Neuronal Degeneration and Axon Regeneration after Acute Injury

(2017) Alexander M. Hilla et al.   JOURNAL OF NEUROSCIENCE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

An updated assessment of microglia depletion: current concepts and future directions

(2017) Jinming Han et al.   Molecular Brain

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

(2016) Xi Feng et al.   Journal of Neuroinflammation

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke

(2016) Gergely Szalay et al.   Nature Communications

Elimination of microglia improves cognitive function following cranial irradiation

(2016) Munjal M. Acharya et al.   Scientific Reports

Neutralization of colony-stimulating factor 1 receptor prevents sickness behavior syndrome by reprogramming inflammatory monocytes to produce IL-10

(2015) Andreas Felix Müller et al.   BRAIN BEHAVIOR AND IMMUNITY

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System

(2015) Julia Bruttger et al.   IMMUNITY

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

(2014) Diana M. Norden et al.   GLIA

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Adjuvant effect of diphtheria toxin after mucosal administration in both wild type and diphtheria toxin receptor engineered mouse strains

(2013) Timothy J. Chapman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging

(2012) J. Vukovic et al.   JOURNAL OF NEUROSCIENCE

Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling

(2011) D. A. Hume et al.   BLOOD

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration

(2008) Caroline André et al.   JOURNAL OF NEUROIMMUNOLOGY

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Microglia—A Wrench in the Running Wheel?

(2008) Saul Villeda et al.   NEURON

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE