Article
Neurosciences
Kristina G. Witcher, Chelsea E. Bray, Titikorn Chunchai, Fangli Zhao, Shane M. O'Neil, Alan J. Gordillo, Warren A. Campbell, Daniel B. McKim, Xiaoyu Liu, Julia E. Dziabis, Ning Quan, Daniel S. Eiferman, Andy J. Fischer, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury can lead to significant neuropsychiatric problems and neurodegenerative pathologies that last for years. This study showed that microglia play a crucial role in acute and chronic stages of TBI, influencing inflammation and neuropathology development, which in turn affect neuronal homeostasis and behavioral outcomes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Gundega Stelfa, Edijs Vavers, Baiba Svalbe, Rinalds Serzants, Anna Miteniece, Lasma Lauberte, Solveiga Grinberga, Baiba Gukalova, Maija Dambrova, Liga Zvejniece
Summary: S1R deficiency reduces TBI-induced motor coordination impairments by reducing GFAP expression in Bergmann glial cells in the cerebellum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yibin Jia, Guanyi Wang, Yuqing Ye, Enming Kang, Huijun Chen, Zishuo Guo, Xiaosheng He
Summary: TBI is a disease with high morbidity and disability worldwide, despite ongoing neural protection efforts. Due to patient heterogeneity, it is difficult to achieve satisfying results in clinic. Neuroinflammation appears since primary injury occurs, and recent studies suggest NSCs play a central role in neural regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Jianqin Xue, Yu Zhang, Junhua Zhang, Zhujun Zhu, Qi Lv, Jianhua Su
Summary: This study revealed the important role of astrocyte-derived CCL7 in promoting microglia-mediated inflammation after TBI, suggesting CCL7 could serve as a potential therapeutic strategy for attenuating TBI by inhibiting microglial activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ana Belen Lopez-Rodriguez, Celine Decouty-Perez, Victor Farre-Alins, Alejandra Palomino-Antolin, Paloma Narros-Fernandez, Javier Egea
Summary: Despite numerous studies, many mechanisms underlying traumatic brain injury (TBI) remain unknown. This study investigates the role of NLRP3 inflammasome in neuroinflammation and glial response in TBI. The results highlight the importance of time-dependent activation of NLRP3 and its regulation in fine-tuning the glial response.
Article
Neurosciences
Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouvina, Mollie Witzel, Jonathan P. Godbout
Summary: The neurobiological mechanisms underlying worsened functional outcomes after traumatic brain injury (TBI) in the elderly remain unclear. This study found that aged mice showed more severe cognitive impairment, gliosis, and neuroinflammation after TBI compared to adult mice. Age was associated with enhanced expression of cytokine/chemokine, complement, innate immune, and interferon-associated inflammatory genes in the cortex. Type I interferon (IFN) signaling was significantly enhanced in the aged brain after TBI. Overall, TBI promoted amplified IFN signaling in aged mice, resulting in extended inflammation and gliosis.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Macarena Lorena Herrera, Sandra Bandin, Leandro Gabriel Champarini, Claudia Beatriz Herenu, Maria Jose Bellini
Summary: Intramuscular IGF-1 gene therapy following TBI increased serum IGF1 levels, improved working memory, and reduced the number of reactive glial cells. This approach may represent a new strategy to prevent outcomes of traumatic brain injury in rats.
BRAIN RESEARCH BULLETIN
(2021)
Article
Immunology
James P. Barrett, Susan M. Knoblach, Surajit Bhattacharya, Heather Gordish-Dressman, Bogdan A. Stoica, David J. Loane
Summary: Aging negatively affects brain inflammatory processes, especially in the context of traumatic brain injury (TBI), where aged mice show exacerbated neuroinflammation and IFN-I signaling compared to their younger counterparts. The activation of cGAS and IFN-I pathways in the aged TBI brain may serve as a mechanistic link between neuroinflammation and neurodegeneration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Karen Krukowski, Amber Nolan, McKenna Becker, Katherine Picard, Nathalie Vernoux, Elma S. Frias, Xi Feng, Marie-Eve Tremblay, Susanna Rosi
Summary: The study revealed that one week after brain injury, microglia exhibit increased phagocytic activity, synaptic engulfment, and neuronal contact, which may contribute to cognitive deficits. By utilizing state-of-the-art techniques, novel microglia-mediated mechanisms that impact neuronal function after TBI were uncovered.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Marine Tessier, Marta Saez Garcia, Emmanuelle Goubert, Edith Blasco, Amandine Consumi, Benoit Dehapiot, Li Tian, Florence Molinari, Jerome Laurin, Francois Guillemot, Christian A. Huebner, Christophe Pellegrino, Claudio Rivera
Summary: The study reveals a novel mechanism of action for the Na-K-Cl cotransporter (NKCC1) inhibitor bumetanide in neurological disorders. It shows that bumetanide accelerates microglial activation dynamics, resulting in an increase in parvalbumin interneuron survival through increased microglial BDNF expression and contact with interneurons.
Article
Immunology
Brittany P. Todd, Michael S. Chimenti, Zili Luo, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
Summary: The study revealed sustained, lineage-specific transcriptional changes in both microglia and astrocytes following severe TBI, with microglia showing a greater transcriptional response than astrocytes at a subacute time point. Both microglia and astrocytes were enriched for genes related to type I interferon signaling and MHC class I antigen presentation. The transcriptional response of microglia and astrocytes to severe TBI was distinct from prior reports in mild TBI and other neurodegenerative and neuroinflammatory diseases.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Neurosciences
Mengqi Yuan, Haitao Wu
Summary: Astrocytes play a crucial role in controlling processes in the nervous system after brain injury, producing neuroprotective factors while also potentially hindering CNS repair. Understanding the dual role of astrocytes may improve post-brain injury recovery and lead to the development of novel therapeutic strategies for TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Physiology
Rodrigo G. Mira, Matias Lira, Waldo Cerpa
Summary: Traumatic brain injury (TBI) is a heterogeneous disorder that causes brain damage due to external forces, leading to CNS damage under various mechanisms. Glial cells such as astrocytes, microglia, and oligodendrocytes play crucial roles in response to TBI, affecting neuronal damage and pathophysiology.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Immunology
Yu Chen, Fu Peng, Ziwei Xing, Junren Chen, Cheng Peng, Dan Li
Summary: Neuroinflammation is an immune response in the central nervous system that is involved in various brain diseases. Flavonoids can alleviate neuroinflammation by inhibiting inflammatory mediators, promoting anti-inflammatory factors, and modulating glial cell polarization. They have therapeutic potential for brain disorders associated with neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qian Jiang, Ding Wei, Xuejun He, Chao Gan, Xiaobing Long, Huaqiu Zhang
Summary: Phillyrin (Phi) prevents BBB damage by inhibiting neuroinflammation of microglia through the PPAR gamma/NF-kappa B pathway, providing a potential therapeutic drug against TBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Katherine R. Giordano, Charlotte R. Denman, Hannah K. Dollish, Fabian Fernandez, Jonathan Lifshitz, Murtaza Akhter, Rachel K. Rowe
EXPERIMENTAL NEUROLOGY
(2020)
Article
Critical Care Medicine
Zoe M. Tapp, Julia E. Kumar, Kristina G. Witcher, Ravitej R. Atluri, John A. Velasquez, Shane M. O'Neil, Julia E. Dziabis, Chelsea E. Bray, John F. Sheridan, Jonathan P. Godbout, Olga N. Kokiko-Cochran
JOURNAL OF NEUROTRAUMA
(2020)
Article
Multidisciplinary Sciences
Chelsea D. Pernici, Rachel K. Rowe, P. Timothy Doughty, Mahboubeh Madadi, Jonathan Lifshitz, Teresa A. Murray
SCIENTIFIC REPORTS
(2020)
Article
Critical Care Medicine
Maha Saber, Amanda D. Rice, Immaculate Christie, Rebecca G. Roberts, Kenneth S. Knox, Peter Nakaji, Rachel K. Rowe, Ting Wang, Jonathan Lifshitz
Summary: Traumatic brain injury can lead to acute lung injury, and remote ischemic conditioning may mitigate the detrimental outcomes. This study showed that RIC reduced lung damage in TBI mice by regulating the S1P-dependent pathway, indicating its potential as an intervention for TBI-induced ALI.
Article
Multidisciplinary Sciences
Maha Saber, Khyati V. Pathak, Marissa McGilvrey, Krystine Garcia-Mansfield, Jordan L. Harrison, Rachel K. Rowe, Jonathan Lifshitz, Patrick Pirrotte
SCIENTIFIC REPORTS
(2020)
Article
Pediatrics
David M. Notrica, Lisa Kirsch, Shivani Misra, Cara Kelly, Jodie Greenberg, J. Bryce Ortiz, Rachel K. Rowe, Jonathan Lifshitz, P. David Adelson, Rachael L. Stottlemyre, Aaron Cohen, Lois W. Sayrs
Summary: The study evaluated the clinical and social risks associated with fatal and non-fatal Abusive Head Trauma (AHT) in children. Clinical factors such as multiple fractures, bruising, seizures, and social factors like prior police involvement, substance abuse were found to increase the risk of AHT. Unknown number of adults in the home and intimate partner violence were also associated with a higher risk of AHT.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Neurosciences
Tabitha R. F. Green, J. Bryce Ortiz, Sue Wonnacott, Robert J. Williams, Rachel K. Rowe
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Neurosciences
Kristina G. Witcher, Chelsea E. Bray, Titikorn Chunchai, Fangli Zhao, Shane M. O'Neil, Alan J. Gordillo, Warren A. Campbell, Daniel B. McKim, Xiaoyu Liu, Julia E. Dziabis, Ning Quan, Daniel S. Eiferman, Andy J. Fischer, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury can lead to significant neuropsychiatric problems and neurodegenerative pathologies that last for years. This study showed that microglia play a crucial role in acute and chronic stages of TBI, influencing inflammation and neuropathology development, which in turn affect neuronal homeostasis and behavioral outcomes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Maha Saber, Sean M. Murphy, Yerin Cho, Jonathan Lifshitz, Rachel K. Rowe
Summary: The study found that in elderly individuals, TBI induces more profound sleep alterations than AD, although both diseases likely include cognitive impairments. Unique pathological sleep pathways may exist in elderly individuals with TBI compared to those with AD, potentially requiring disease-specific treatments in clinical settings.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Critical Care Medicine
Rachel K. Rowe, Sean M. Murphy, Hirsch Handmaker, Jonathan Lifshitz
Summary: This study revealed a strong association between TBI and domestic violence in Arizona, with males predominantly being child abuse victims and whites/Hispanics making up the majority of victims. Native Americans and Blacks had higher rates of diagnosis compared to state demographics. Half of the cases involved intimate partners, highlighting the importance of TBI screening in suspected DV patients.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Biology
Brittany Gerald, J. Bryce Ortiz, Tabitha R. F. Green, S. Danielle Brown, P. David Adelson, Sean M. Murphy, Rachel K. Rowe
Summary: Pediatric traumatic brain injury (TBI) is a major cause of death and disabilities in children and adolescents. Sleep problems following TBI can significantly impact recovery and outcomes. This study investigated the prevalence of sleep-wake disturbances (SWD) in children with TBI and identified several risk factors, such as age and injury severity. Untreated sleep problems after TBI can worsen symptoms, prolong hospital stays, and delay return to school. Identifying these risk factors can improve the diagnosis, management, and treatment of sleep problems in pediatric TBI survivors.
Article
Biology
Rachel K. Rowe, Tabitha R. F. Green, Katherine R. Giordano, J. Bryce Ortiz, Sean M. Murphy, Mark R. Opp
Summary: Microglia are found to play a critical role in regulating sleep after an immune challenge. Depletion of microglia results in increased sleep following an inflammatory injection, while repopulation of microglia leads to changes in sleep patterns. This study suggests that microglia are necessary for sleep regulation after inflammation.
Article
Criminology & Penology
Lois W. Sayrs, J. Bryce Ortiz, David M. Notrica, Lisa Kirsch, Cara Kelly, Rachael Stottlemyre, Aaron Cohen, Shivani Misra, Tabitha R. Green, P. David Adelson, Jonathan Lifshitz, Rachel K. Rowe
Summary: This study found that intimate partner violence (IPV) is an associated risk factor for pediatric abusive head trauma (AHT), particularly in infants under 12 months old. Identifying IPV along with other family factors in medical settings can improve detection and surveillance of AHT, leading to a reduction in injury, disability, and death.
JOURNAL OF INTERPERSONAL VIOLENCE
(2022)
Article
Immunology
Caroline J. Smith, Marcy A. Kingsbury, Julia E. Dziabis, Richa Hanamsagar, Karen E. Malacon, Jessica N. Tran, Haley A. Norris, Mary Gulino, Evan A. Bordt, Staci D. Bilbo
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Neurosciences
Kristina G. Witcher, Julia E. Dziabis, Chelsea E. Bray, Alan J. Gordillo, Julia E. Kumar, Daniel S. Eiferman, Jonathan P. Godbout, Olga N. Kokiko-Cochran