STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE

STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation

(2014) Wanqiang Sheng et al.   CELL RESEARCH

Stat4 Isoforms Differentially Regulate Inflammation and Demyelination in Experimental Allergic Encephalomyelitis

(2014) C. Mo et al.   JOURNAL OF IMMUNOLOGY

STAT4 Isoforms Differentially Regulate Th1 Cytokine Production and the Severity of Inflammatory Bowel Disease

(2014) J. T. O'Malley et al.   JOURNAL OF IMMUNOLOGY

IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells

(2014) R. Noster et al.   Science Translational Medicine

Opposing Roles of STAT4 and Dnmt3a in Th1 Gene Regulation

(2013) D. Pham et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Pathogenicity of IFN- -Producing Th17 Cells Is Independent of T-bet

(2013) R. Duhen et al.   JOURNAL OF IMMUNOLOGY

IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms

(2013) Wen-I Yeh et al.   JOURNAL OF NEUROIMMUNOLOGY

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

STATs Shape the Active Enhancer Landscape of T Cell Populations

(2012) Golnaz Vahedi et al.   CELL

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

(2012) Emily Pierson et al.   IMMUNOLOGICAL REVIEWS

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

TH17 cytokines in autoimmune neuro-inflammation

(2011) Burkhard Becher et al.   CURRENT OPINION IN IMMUNOLOGY

Autoreactive Tbet-Positive CD4 T Cells Develop Independent of Classic Th1 Cytokine Signaling during Experimental Autoimmune Encephalomyelitis

(2011) Wen-I Yeh et al.   JOURNAL OF IMMUNOLOGY

GM-CSF: the secret weapon in the TH17 arsenal

(2011) Mandy J McGeachy   NATURE IMMUNOLOGY

Fate mapping of IL-17-producing T cells in inflammatory responses

(2011) Keiji Hirota et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis?

(2010) Amy E. Lovett-Racke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

EAE mediated by a non-IFN-γ/non-IL-17 pathway

(2010) Mark A. Kroenke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation

(2010) Lai Wei et al.   IMMUNITY

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

(2010) Ryuta Mukasa et al.   IMMUNITY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Temporal Induction Pattern of STAT4 Target Genes Defines Potential for Th1 Lineage-Specific Programming

(2009) S. R. Good et al.   JOURNAL OF IMMUNOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

(2008) Mark A. Kroenke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ING4 Tumor Suppressor Attenuates NF- B Activity at the Promoters of Target Genes

(2008) S. Nozell et al.   MOLECULAR AND CELLULAR BIOLOGY

IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants

(2008) Roelof A. de Paus et al.   MOLECULAR IMMUNOLOGY

Memory CD4 T cells emerge from effector T-cell progenitors

(2008) Laurie E. Harrington et al.   NATURE