Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

Hsa-let-7c-5p augments enterovirus 71 replication through viral subversion of cell signaling in rhabdomyosarcoma cells

(2017) Bingfei Zhou et al.   Cell and Bioscience

Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis

(2016) Xue Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rifampicin attenuates experimental autoimmune encephalomyelitis by inhibiting pathogenic Th17 cells responses

(2016) Ke Ma et al.   JOURNAL OF NEUROCHEMISTRY

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

(2016) Debayon Paul et al.   Journal of Neuroinflammation

Molecular Changes Associated with the Protective Effects of Angiopoietin-1 During Blood-Brain Barrier Breakdown Post-Injury

(2016) Sukriti Nag et al.   MOLECULAR NEUROBIOLOGY

Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling

(2015) Axel Haarmann et al.   ACTA NEUROPATHOLOGICA

miR-21 alleviates secondary blood–brain barrier damage after traumatic brain injury in rats

(2015) Xintong Ge et al.   BRAIN RESEARCH

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies

(2015) Mireia Pérez-Verdaguer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Dysfunction of brain pericytes in chronic neuroinflammation

(2015) Yuri Persidsky et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Multiple sclerosis lesion formation and early evolution revisited: A weekly high-resolution magnetic resonance imaging study

(2015) Charles RG Guttmann et al.   Multiple Sclerosis Journal

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

(2015) Jorge Ivan Alvarez et al.   NEUROBIOLOGY OF DISEASE

Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

(2015) Sveinung Fjær et al.   NEUROCHEMISTRY INTERNATIONAL

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases

(2015) Yipeng Zhao et al.   Toxins

Multiple sclerosis lesion formation and early evolution revisited: A weekly high-resolution magnetic resonance imaging study

(2015) Charles RG Guttmann et al.   Multiple Sclerosis Journal

Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin

(2015) M. Rizwan Siddiqui et al.   PLoS One

Interferon-γ Safeguards Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis

(2014) Chen Ni et al.   AMERICAN JOURNAL OF PATHOLOGY

The formation of inflammatory demyelinated lesions in cerebral white matter

(2014) Pietro Maggi et al.   ANNALS OF NEUROLOGY

Role of the Blood–Brain Barrier in Multiple Sclerosis

(2014) Genaro Gabriel Ortiz et al.   ARCHIVES OF MEDICAL RESEARCH

Angiopoietin-1 ameliorates inflammation-induced vascular leakage and improves functional impairment in a rat model of acute experimental autoimmune encephalomyelitis

(2014) Hong Jiang et al.   EXPERIMENTAL NEUROLOGY

The Extracellular Matrix Protein Laminin  2 Regulates the Maturation and Function of the Blood-Brain Barrier

(2014) M. J. Menezes et al.   JOURNAL OF NEUROSCIENCE

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

(2014) M. Harunur Rashid et al.   Scientific Reports

Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice

(2013) Bin Li et al.   EXPERIMENTAL NEUROLOGY

Abnormal blood–brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI

(2013) S.P. Cramer et al.   NeuroImage-Clinical

Inflammatory cell trafficking across the blood-brain barrier: chemokine regulation and in vitro models

(2012) Yukio Takeshita et al.   IMMUNOLOGICAL REVIEWS

Selective Inhibition of CCR7−Effector Memory T Cell Activation by a Novel Peptide Targeting Kv1.3 Channel in a Rat Experimental Autoimmune Encephalomyelitis Model

(2012) Zhi Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood-Brain Barrier Alterations in the Cerebral Cortex in Experimental Autoimmune Encephalomyelitis

(2012) Mariella Errede et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Pathology of Demyelinating Diseases

(2011) Bogdan F.Gh. Popescu et al.   Annual Review of Pathology-Mechanisms of Disease

Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse

(2011) Evelyn Peelen et al.   JOURNAL OF NEUROIMMUNOLOGY

Angiogenesis is Regulated by Angiopoietins During Experimental Autoimmune Encephalomyelitis and is Indirectly Related to Vascular Permeability

(2011) Carolyn J. MacMillan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

Disruption of central nervous system barriers in multiple sclerosis

(2010) Jorge Ivan Alvarez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE

(2010) Jami Bennett et al.   JOURNAL OF NEUROIMMUNOLOGY

ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates

(2010) Song Han et al.   TOXICON

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

(2009) Srikant Rangaraju et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cellular mechanisms of IL-17-induced blood-brain barrier disruption

(2009) Jula Huppert et al.   FASEB JOURNAL

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease

(2008) Song Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY