Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity

(2019) Tomás Cerdó et al.   Nutrients

Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model

(2019) Hong Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial

(2019) Edward S Chambers et al.   GUT

Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome–gut–brain axis modulation

(2019) Shokouh Ahmadi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Impact of prebiotics on the rheological characteristics and volatile compounds of Greek yogurt

(2019) Marília F. Costa et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives

(2019) Natalia Vallianou et al.   Current Obesity Reports

Clinical and psychological responses to synbiotic supplementation in obese or overweight adults: A randomized clinical trial

(2019) Amir Hadi et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Impact of probiotics and prebiotics on food texture

(2019) Jonas T Guimarães et al.   Current Opinion in Food Science

Dietary α-cyclodextrin modifies gut microbiota and reduces fat accumulation in high-fat-diet-fed obese mice

(2018) Nanako Nihei et al.   BIOFACTORS

The Global Epidemic of the Metabolic Syndrome

(2018) Mohammad G. Saklayen   CURRENT HYPERTENSION REPORTS

Functional cream cheese supplemented with Bifidobacterium animalis subsp. lactis DSM 10140 and Lactobacillus reuteri DSM 20016 and prebiotics

(2018) Barbara Speranza et al.   FOOD MICROBIOLOGY

Cyclodextrins: structure, physicochemical properties and pharmaceutical applications

(2018) Phatsawee Jansook et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

(2018) Joohee Kim et al.   JOURNAL OF MEDICINAL FOOD

Short-chain fatty acids suppress food intake by activating vagal afferent neurons

(2018) Chayon Goswami et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: A 10-week randomized controlled trial

(2018) M. Mohammadi-Sartang et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

A polyphenol-rich prebiotic in combination with a novel probiotic formulation alleviates markers of obesity and diabetes in Drosophila

(2018) Susan Westfall et al.   Journal of Functional Foods

Synbiotics for Improved Human Health: Recent Developments, Challenges, and Opportunities

(2018) Janina A. Krumbeck et al.   Annual Review of Food Science and Technology

Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders

(2018) Aleksandra Tarasiuk et al.   Chinese Medicine

A selective gut bacterial bile salt hydrolase alters host metabolism

(2018) Lina Yao et al.   eLife

Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function

(2018) Ana Agustí et al.   Frontiers in Neuroscience

Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children

(2018) Jesús Sanchis-Chordà et al.   EUROPEAN JOURNAL OF NUTRITION

Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial

(2018) Anna Pedret et al.   INTERNATIONAL JOURNAL OF OBESITY

METABOLIC ENDOTOXEMIA PROMOTES ADIPOSE DYSFUNCTION AND INFLAMMATION IN HUMAN OBESITY

(2018) Mercedes Clemente-Postigo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Combination of two β-galactosidases during the synthesis of galactooligosaccharides may enhance yield and structural diversity

(2018) Christin Fischer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Probiotics supplementation for the obesity management; A systematic review of animal studies and clinical trials

(2018) Hanieh-Sadat Ejtahed et al.   Journal of Functional Foods

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

(2017) Zhuang Li et al.   GUT

Synbiotic ice cream containing yacon flour and Lactobacillus acidophylus NCFM

(2017) Gilson Parussolo et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Brain–gut–microbiota axis — mood, metabolism and behaviour

(2017) Timothy G. Dinan et al.   Nature Reviews Gastroenterology & Hepatology

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

(2017) Emanuel E. Canfora et al.   Scientific Reports

Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

(2016) C. M. van der Beek et al.   CLINICAL SCIENCE

Antiobesity effect of Pediococcus pentosaceus LP28 on overweight subjects: a randomized, double-blind, placebo-controlled clinical trial

(2016) F Higashikawa et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Microbiota-induced obesity requires farnesoid X receptor

(2016) Ava Parséus et al.   GUT

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Probiotics History

(2016) Giovanni Gasbarrini et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Persistent microbiome alterations modulate the rate of post-dieting weight regain

(2016) Christoph A. Thaiss et al.   NATURE

Diet-induced extinctions in the gut microbiota compound over generations

(2016) Erica D. Sonnenburg et al.   NATURE

Gut Microbiota: Modulation of Host Physiology in Obesity

(2016) Vandana Nehra et al.   PHYSIOLOGY

Recent advances on prebiotic lactulose production

(2016) Azis Boing Sitanggang et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome

(2016) Marc A. Sze et al.   mBio

Polydextrose: Physiological Function, and Effects on Health

(2016) Mariane do Carmo et al.   Nutrients

Influence of food matrix on the viability of probiotic bacteria: A review based on dairy and non-dairy beverages

(2016) Amal Bakr Shori   Food Bioscience

Application of inulin in cheese as prebiotic, fat replacer and texturizer: A review

(2015) Reza Karimi et al.   CARBOHYDRATE POLYMERS

Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota

(2015) C. T. Peterson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models

(2015) Sarah Forbes et al.   DIABETES

Regulation of Appetite, Satiation, and Body Weight by Enteroendocrine Cells. Part 2: Therapeutic Potential of Enteroendocrine Cells in the Treatment of Obesity

(2015) Carsten Posovszky et al.   Hormone Research in Paediatrics

Gut microbiota composition correlates with changes in body fat content due to weight loss

(2015) M. Remely et al.   Beneficial Microbes

Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry

(2015) M. Fredua-Agyeman et al.   Beneficial Microbes

Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis

(2014) A. Alisi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Bile acids, obesity, and the metabolic syndrome

(2014) Huijuan Ma et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

Positive interaction between prebiotics and thiazolidinedione treatment on adiposity in diet-induced obese mice

(2014) Maud Alligier et al.   Obesity

Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut

(2014) S. A. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Fructo-oligosaccharides: Production, Purification and Potential Applications

(2013) Vandana Bali et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria,in vitro

(2013) Karen P. Scott et al.   FEMS MICROBIOLOGY ECOLOGY

A new method to produce synbiotic Fiordilatte cheese

(2013) L. Angiolillo et al.   Innovative Food Science & Emerging Technologies

Oral Supplementation With ProbioticL. reuteriNCIMB 30242 Increases Mean Circulating 25-Hydroxyvitamin D: A Post Hoc Analysis of a Randomized Controlled Trial

(2013) Mitchell L. Jones et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HPMC and inulin as fat replacers in biscuits: Sensory and instrumental evaluation

(2013) Laura Laguna et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: A randomized controlled clinical trial

(2013) Parvin Dehghan et al.   NUTRITION

Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients - a randomized double-blind placebo-controlled pilot study

(2013) Khaider K Sharafedtinov et al.   Nutrition Journal

Combined effects of oligofructose andBifidobacterium animalison gut microbiota and glycemia in obese rats

(2013) Marc R. Bomhof et al.   Obesity

Oral Probiotic Microcapsule Formulation Ameliorates Non-Alcoholic Fatty Liver Disease in Bio F1B Golden Syrian Hamsters

(2013) Jasmine Bhathena et al.   PLoS One

Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in Diet-Induced Obese Mice Is Associated with Gut Microbial Changes and Reduction in Obesity

(2013) Do-Young Park et al.   PLoS One

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Prebiotics as functional foods: A review

(2013) Sadeq Hasan Al-Sheraji et al.   Journal of Functional Foods

Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes

(2013) Bahram Pourghassem Gargari et al.   Diabetes & Metabolism Journal

Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties

(2012) Jean-Michel Lecerf et al.   BRITISH JOURNAL OF NUTRITION

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

(2012) Evelyne M Dewulf et al.   GUT

Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver

(2012) Claudia Cicione et al.   HEPATOLOGY

Rheological and sensory attributes of cream caramel desserts containing fructooligosaccharides as substitute sweeteners

(2012) Styliani V. Protonotariou et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations

(2012) Chenhong Zhang et al.   ISME Journal

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Dietary resistant starch dose-dependently reduces adiposity in obesity-prone and obesity-resistant male rats

(2012) Damien P Belobrajdic et al.   Nutrition & Metabolism

Obesity and C-reactive protein in various populations: a systematic review and meta-analysis

(2012) J. Choi et al.   Obesity Reviews

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Comparative analysis of the gene expression profile of probiotic Lactobacillus casei Zhang with and without fermented milk as a vehicle during transit in a simulated gastrointestinal tract

(2012) Jicheng Wang et al.   RESEARCH IN MICROBIOLOGY

Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults

(2011) Mitchell L. Jones et al.   BRITISH JOURNAL OF NUTRITION

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects

(2011) A. L. Harte et al.   DIABETES CARE

Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats

(2011) K.B.M. Saiful Islam et al.   GASTROENTEROLOGY

Effect of inulin as prebiotic and synbiotic interactions between probiotics to improve fermented milk firmness

(2011) Ricardo Pinheiro de Souza Oliveira et al.   JOURNAL OF FOOD ENGINEERING

Physicochemical properties and sensory evaluation of fructoligosaccharide enriched cookies

(2011) C. Handa et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Prebiotic effects: metabolic and health benefits

(2010) Marcel Roberfroid et al.   BRITISH JOURNAL OF NUTRITION

Xylooligosaccharides (XOS) as an Emerging Prebiotic: Microbial Synthesis, Utilization, Structural Characterization, Bioactive Properties, and Applications

(2010) Ayyappan Appukuttan Aachary et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial

(2010) Y Kadooka et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

Food Formats for Effective Delivery of Probiotics

(2010) Mary Ellen Sanders et al.   Annual Review of Food Science and Technology

Probiotics lower plasma glucose in the high-fat fed C57BL/6J mouse

(2010) U. Andersson et al.   Beneficial Microbes

Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

(2009) Jill A Parnell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

(2009) Patrice D Cani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice

(2009) Chenhong Zhang et al.   ISME Journal

Acetic Acid Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in Liver To Suppress Body Fat Accumulation

(2009) Tomoo Kondo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents

(2008) June Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function

(2008) Julia B. Ewaschuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents

(2008) I Nadal et al.   INTERNATIONAL JOURNAL OF OBESITY

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of processing conditions on the prebiotic activity of commercial prebiotics

(2007) J. Huebner et al.   INTERNATIONAL DAIRY JOURNAL