Article
Nutrition & Dietetics
Xuanli Liu, Gaosheng Hu, Anhua Wang, Guoqing Long, Yongcheng Yang, Dongdong Wang, Nanfang Zhong, Jingming Jia
Summary: Black tea has preventive effects on HFD-induced obesity by altering gut microbiota, tissue gene expression, and DNA methylation levels. The anti-obesity properties of black tea are attributed to alkaloids, and the mechanism of action is closely related to the gut microbiota.
Review
Nutrition & Dietetics
Daniel E. Radford-Smith, Daniel C. Anthony
Summary: Emerging evidence suggests that alterations in the gut microbiota can impact mood and contribute to the development of depression through the microbiota-gut-brain axis. Preclinical studies in rodents have demonstrated that prebiotics and probiotics can modulate the gut microbiota and affect neurochemical signaling and inflammatory pathways in the brain. In humans, probiotic supplementation has shown modest antidepressant effects, but further research is needed in clinically relevant populations. This review critically discusses the role of the microbiota-gut-brain axis in depression and emphasizes the importance of rigorous clinical trials and mechanistic understanding for translating preclinical findings into novel therapies.
Review
Biochemistry & Molecular Biology
Akari Nishida, Yuna Ando, Ikuo Kimura, Junki Miyamoto
Summary: This article reviews the association between diet, gut microbiota, and host energy homeostasis, with a focus on the risks of obesity and metabolic disorders and the impact of gut microbiota on host energy balance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Eun-Ji Song, Na Rae Shin, Songhee Jeon, Young-Do Nam, Hojun Kim
Summary: This study aimed to explore the effects of lorcaserin (LS) and phentermine (PT) on obesity and gut microbiota. The results showed that LS and PT can modulate the composition of gut microbiota and restore gut microbial dysbiosis, which is strongly correlated with obesity-related markers. Additionally, LS and PT increased the mRNA level of G protein-coupled receptor 120 (GPR120) and correlated with obesity-related markers.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Fang Zhou, Yi-Long Li, Xin Zhang, Kun-Bo Wang, Jian-An Huang, Zhong-Hua Liu, Ming-Zhi Zhu
Summary: The study found that FBTP supplementation effectively reduced obesity in HFD-fed rats by improving intestinal oxidative stress and barrier function, as well as attenuating gut microbiota dysbiosis induced by HFD. Specific core microbes, including Akkermansia muciniphila, Alloprevotella, Bacteroides, and Faecalibaculum, were improved by FBTPs. The antiobesity effect of FBTPs was shown to be dependent on gut microbiota, as demonstrated by a fecal microbiota transplantation experiment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Genetics & Heredity
Vipin Arora, Gurjit Singh, Insug O-Sullivan, Kaige Ma, Arivarasu Natarajan Anbazhagan, E. Gina Votta-Velis, Benjamin Bruce, Ripper Richard, Andre J. van Wijnen, Hee-Jeong Im
Summary: Osteoarthritis is a common medical condition affecting millions worldwide with no approved disease-modifying drugs available, and symptom palliation being the only option. Research suggests a link between gut microbiota and OA development, with probiotics and prebiotics potentially offering a new approach in OA treatment.
Article
Food Science & Technology
Teresa Requena, Ya Song, Carmen Pelaez, M. Carmen Martinez-Cuesta
Summary: The study used a simulator to culture the gut microbiota from obese individuals, finding differences in the microbiota composition compared to normal-weight individuals, with key bacterial species missing and other changes occurring when high-fermented carbohydrates and fructose beverages were consumed by the obese individuals. These findings suggest potential strategies for targeted production of propionate by the human gut microbiota in relation to obesity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Berkay Bozkurt, Gamze Terlemez, Efe Sezgin
Summary: The importance of bacterial microbiota on host metabolism and obesity risk is well known, but the role of fungal microbiota is largely unknown. This study investigated the role of microbiota on fat metabolism in fruit flies and found that fungal microbiota can have a major impact on host fat metabolism. The interactions between fungal and bacterial microbiota may influence host storage metabolite pools and obesity risk.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Laurie Lynn Carelli, Patrizia D'Aquila, Francesco de Rango, Armida Incorvaia, Giada Sena, Giuseppe Passarino, Dina Bellizzi
Summary: Different nutritional regimens can have beneficial effects on obesity by regulating gut microbiota composition and function. In this study, obese subjects underwent two dietary interventions for 8 weeks: a low-calorie diet and a two-phase (ketogenic plus low-calorie) diet. Anthropometric and clinical parameters were evaluated, and gut microbiota composition was assessed. Significant reductions in abdominal circumference and insulin levels were observed in subjects following the two-phase diet. Changes in gut microbial composition were also observed, including a decrease in Proteobacteria and an increase in Verrucomicrobiaceae in both diets. Only the two-phase diet resulted in an increase in Bacteroidetes. These findings suggest that targeted nutritional regimens and probiotic use can modulate gut microbiota to achieve a favorable composition and restore the balance disrupted by obesity and other conditions.
Article
Pharmacology & Pharmacy
Na Rae Shin, Shambhunath Bose, Yura Choi, Young-Mi Kim, Young-Won Chin, Eun-Ji Song, Young-Do Nam, Hojun Kim
Summary: The study revealed that fermented Panax notoginseng extract showed benefits in reducing food and calorie intake, as well as affecting gut microbial composition leading to anti-obesity effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Andrea Deledda, Giuseppe Annunziata, Gian Carlo Tenore, Vanessa Palmas, Aldo Manzin, Fernanda Velluzzi
Summary: Dietary antioxidants play a role in influencing gut microbiota composition, inflammation, and obesity, potentially impacting the development of chronic diseases related to oxidative stress and maintaining health.
Article
Food Science & Technology
Shuo Li, Jinming You, Zirui Wang, Yue Liu, Bo Wang, Min Du, Tiande Zou
Summary: The study showed that curcumin can alleviate hepatic steatosis and insulin resistance in high-fat diet-fed obese mice by modulating gut microbiota composition and metabolites.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Jose Alberto Molina-Tijeras, Patricia Diez-Echave, Teresa Vezza, Laura Hidalgo-Garcia, Antonio Jesus Ruiz-Malagon, Maria Jesus Rodriguez-Sojo, Miguel Romero, Inaki Robles-Vera, Federico Garcia, Julio Plaza-Diaz, Monica Olivares, Juan Duarte, Maria Elena Rodriguez-Cabezas, Alba Rodriguez-Nogales, Julio Galvez
Summary: Studies have shown that Lactobacillus fermentum CECT5716 demonstrates anti-obesity effects in a model of high fat diet-induced obesity in mice, along with improvements in anti-inflammatory properties, endothelial dysfunction, and gut dysbiosis. This probiotic modulates the microbiome by increasing beneficial bacteria abundance, reducing harmful bacterial presence, suggesting a potential use in the treatment of obesity.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Henry H. Le, Min-Ting Lee, Kevin R. Besler, Elizabeth L. Johnson
Summary: Microbially-derived gut metabolites play an important role in host phenotypes. This study traces bacterial sphingolipids from gut symbiont Bacteroides thetaiotaomicron to mouse colons and livers, and finds that bacterial sphingolipid synthesis can rescue excess lipid accumulation in a mouse model of hepatic steatosis. The transfer of this sphingolipid to the liver potentially contributes to microbiota-mediated liver function.
CELL HOST & MICROBE
(2022)
Review
Cell Biology
Marc D. Cook, Jacob M. Allen, Brandt D. Pence, Matthew A. Wallig, H. Rex Gaskins, Bryan A. White, Jeffrey A. Woods
IMMUNOLOGY AND CELL BIOLOGY
(2016)
Article
Physiology
Jacob M. Allen, Margret E. Berg Miller, Brandt D. Pence, Keith Whitlock, Vandana Nehra, H. Rex Gaskins, Bryan A. White, John D. Fryer, Jeffrey A. Woods
JOURNAL OF APPLIED PHYSIOLOGY
(2015)
Article
Nutrition & Dietetics
Matthew R. Panasevich, Jacob M. Allen, Matthew A. Wallig, Jeffrey A. Woods, Ryan N. Dilger
JOURNAL OF NUTRITION
(2015)
Article
Geriatrics & Gerontology
Brandt D. Pence, Tushar K. Bhattacharya, Pul Park, Jennifer L. Rytych, Jacob M. Allen, Yi Sun, Robert H. McCusker, Keith W. Kelley, Rodney W. Johnson, Justin S. Rhodes, Jeffrey A. Woods
EXPERIMENTAL GERONTOLOGY
(2017)
Article
Gastroenterology & Hepatology
Jacob K. Olson, Jason B. Navarro, Jacob M Allen, Christopher J. McCulloh, Lauren Mashburn-Warren, Yijie Wang, Vanessa A. Varaljay, Michael T. Bailey, Steven D. Goodman, Gail E. Besner
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2018)
Article
Behavioral Sciences
Tamar L. Gur, Aditi Vadodkar Palkar, Therese Rajasekera, Jacob Allen, Anzela Niraula, Jonathan Godbout, Michael T. Bailey
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Neurosciences
Grace M. Niemiro, Jacob M. Allen, Lucy J. Mailing, Naiman A. Khan, Hannah D. Holscher, Jeffrey A. Woods, Michael De Lisio
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Sport Sciences
Jacob M. Allen, Lucy J. Mailing, Grace M. Niemiro, Rachel Moore, Marc D. Cook, Bryan A. White, Hannah D. Holscher, Jeffrey A. Woods
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)
Article
Behavioral Sciences
Lucy J. Mailing, Jacob M. Allen, Brandt D. Pence, Jennifer Rytych, Yi Sun, Tushar K. Bhattacharya, Pul Park, Tzu-Wen L. Cross, Robert H. McCusker, Kelly S. Swanson, George C. Fahey, Justin S. Rhodes, Keith W. Kelley, Rodney W. Johnson, Jeffrey A. Woods
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Immunology
Stephanie M. Matt, Jacob M. Allen, Marcus A. Lawson, Lucy J. Mailing, Jeffrey A. Woods, Rodney W. Johnson
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Jacob M. Allen, Robert M. Jaggers, Lindsey M. Solden, Brett R. Loman, Ronald H. Davies, Amy R. Mackos, Christopher A. Ladaika, Brian M. Berg, Maciej Chichlowski, Michael T. Bailey
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Physiology
Mikaela C. Kasperek, Lucy Mailing, Brian D. Piccolo, Becky Moody, Renny Lan, Xiaotian Gao, Diego Hernandez-Saavedra, Jeffrey A. Woods, Sean H. Adams, Jacob M. Allen
Summary: Regular, moderate exercise can modify the gut microbiome and improve human metabolic and immune health. This study found that aerobic exercise training caused changes in both fecal and serum metabolites, particularly within aromatic amino acid metabolic pathways. These metabolites were correlated with body composition, insulin sensitivity, and cardiorespiratory fitness. The findings highlight the importance of considering the microbiome and metabolome in studying the health benefits of exercise.
PHYSIOLOGICAL REPORTS
(2023)
Article
Nutrition & Dietetics
Annabel Biruete, Jacob M. Allen, Brandon M. Kistler, Jin Hee Jeong, Peter J. Fitschen, Kelly S. Swanson, Kenneth R. Wilund
TOPICS IN CLINICAL NUTRITION
(2019)
Article
Gastroenterology & Hepatology
J. M. Allen, L. J. Mailing, J. Cohrs, C. Salmonson, J. D. Fryer, V. Nehra, V. L. Hale, P. Kashyap, B. A. White, J. A. Woods