Metabolic reprogramming of natural killer cells in obesity limits antitumor responses

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity

(2017) Selma Boulenouar et al.   IMMUNITY

Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity

(2016) Byung-Cheol Lee et al.   Cell Metabolism

Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance

(2016) Timothy E. O’Sullivan et al.   IMMUNITY

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Decreased NK cell functions in obesity can be reactivated by fat mass reduction

(2015) Janine Jahn et al.   Obesity

Cell biological steps and checkpoints in accessing NK cell cytotoxicity

(2014) Emily M Mace et al.   IMMUNOLOGY AND CELL BIOLOGY

A Dual Role for Talin in NK Cell Cytotoxicity: Activation of LFA-1-Mediated Cell Adhesion and Polarization of NK Cells

(2014) E. M. Mace et al.   JOURNAL OF IMMUNOLOGY

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

(2014) Raymond P. Donnelly et al.   JOURNAL OF IMMUNOLOGY

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

(2014) Antoine Marçais et al.   NATURE IMMUNOLOGY

Obesity and cancer—mechanisms underlying tumour progression and recurrence

(2014) Jiyoung Park et al.   Nature Reviews Endocrinology

Immune dysfunction and chronic inflammation following spinal cord injury

(2014) D J Allison et al.   SPINAL CORD

Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling

(2013) A. M. James et al.   BLOOD

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell–mediated cytotoxicity

(2013) Amit Tuli et al.   MOLECULAR BIOLOGY OF THE CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

(2012) Nadia R Cohen et al.   NATURE IMMUNOLOGY

Metabolic checkpoints in activated T cells

(2012) Ruoning Wang et al.   NATURE IMMUNOLOGY

Two modes of lytic granule fusion during degranulation by natural killer cells

(2011) Dongfang Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

Rapid Lytic Granule Convergence to the MTOC in Natural Killer Cells Is Dependent on Dynein But Not Cytolytic Commitment

(2010) Ashley N. Mentlik et al.   MOLECULAR BIOLOGY OF THE CELL

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Natural Killer Cells in Obesity: Impaired Function and Increased Susceptibility to the Effects of Cigarette Smoke

(2010) Donal O'Shea et al.   PLoS One

Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial

(2009) Lars Sjöström et al.   LANCET ONCOLOGY

Are Natural Killer Cells Protecting the Metabolically Healthy Obese Patient?

(2009) Lydia A. Lynch et al.   Obesity

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

(2008) A. J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA