The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility
Authors
Keywords
-
Journal
Nature Communications
Volume 8, Issue -, Pages 15074
Publisher
Springer Nature
Online
2017-04-21
DOI
10.1038/ncomms15074
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Reductive carboxylation supports redox homeostasis during anchorage-independent growth
- (2016) Lei Jiang et al. NATURE
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- Dual roles of NRF2 in tumor prevention and progression: Possible implications in cancer treatment
- (2015) Eui Jung Moon et al. FREE RADICAL BIOLOGY AND MEDICINE
- Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation
- (2014) Prashant Mishra et al. Cell Metabolism
- The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
- (2014) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- (2014) Scott J Dixon et al. eLife
- Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
- (2013) Luika A. Timmerman et al. CANCER CELL
- Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis
- (2013) Li Ma et al. CELL
- Glutamine and cancer: cell biology, physiology, and clinical opportunities
- (2013) Christopher T. Hensley et al. JOURNAL OF CLINICAL INVESTIGATION
- Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry
- (2013) L. T. Jae et al. SCIENCE
- The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
- (2012) Jan Lewerenz et al. ANTIOXIDANTS & REDOX SIGNALING
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- How cancer metabolism is tuned for proliferation and vulnerable to disruption
- (2012) Almut Schulze et al. NATURE
- The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
- (2012) Jordi Barretina et al. NATURE
- Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell
- (2012) Toshifumi Yae et al. Nature Communications
- CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
- (2011) Takatsugu Ishimoto et al. CANCER CELL
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Global gene disruption in human cells to assign genes to phenotypes by deep sequencing
- (2011) Jan E Carette et al. NATURE BIOTECHNOLOGY
- Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply
- (2010) Andrew Y. Choo et al. MOLECULAR CELL
- Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
- (2010) Vishal M Gohil et al. NATURE BIOTECHNOLOGY
- The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
- (2010) A. J. Levine et al. SCIENCE
- Glutamine addiction: a new therapeutic target in cancer
- (2010) David R. Wise et al. TRENDS IN BIOCHEMICAL SCIENCES
- The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets
- (2009) J. W. Nicol et al. BIOINFORMATICS
- Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
- (2009) C. Yang et al. CANCER RESEARCH
- Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens
- (2009) J. E. Carette et al. SCIENCE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
- (2009) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
- (2009) Ben Langmead et al. GENOME BIOLOGY
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Analytical strategies for LC–MS-based targeted metabolomics
- (2008) Wenyun Lu et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/β-catenin pathway
- (2008) R-S Chen et al. ONCOGENE
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation