Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation
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Title
Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 48, Pages 19721-19732
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2017-10-17
DOI
10.1074/jbc.m117.814392
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Note: Only part of the references are listed.- The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate
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- Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system
- (2017) Yohei Katoh et al. MOLECULAR BIOLOGY OF THE CELL
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- (2017) Chun-Shik Shin et al. Nature Communications
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- (2017) Alexander Muir et al. eLife
- The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(--)
- (2016) K. Tsuchihashi et al. CANCER RESEARCH
- Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
- (2016) Kimberly J. Briggs et al. CELL
- Increased Expression of System x c − in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance
- (2016) Monika D. Polewski et al. MOLECULAR CANCER RESEARCH
- Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
- (2016) John G Doench et al. NATURE BIOTECHNOLOGY
- Ferroptosis: Death by Lipid Peroxidation
- (2016) Wan Seok Yang et al. TRENDS IN CELL BIOLOGY
- ROS homeostasis and metabolism: a dangerous liason in cancer cells
- (2016) E Panieri et al. Cell Death & Disease
- Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion
- (2015) L Sleire et al. ONCOGENE
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase
- (2014) I. Pader et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy
- (2013) V. Nogueira et al. CLINICAL CANCER RESEARCH
- Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
- (2013) Jaekyoung Son et al. NATURE
- The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
- (2012) Jan Lewerenz et al. ANTIOXIDANTS & REDOX SIGNALING
- Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
- (2012) Patrick S. Ward et al. CANCER CELL
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling
- (2012) Alfeu Zanotto-Filho et al. INVESTIGATIONAL NEW DRUGS
- Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death
- (2012) Nicholas A Graham et al. Molecular Systems Biology
- AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
- (2012) Sang-Min Jeon et al. NATURE
- Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas
- (2012) Satoru Takeuchi et al. NEUROSURGERY
- The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond
- (2011) Marcus Conrad et al. AMINO ACIDS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
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- (2010) Pankaj Kumar Mandal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- xCT deficiency accelerates chemically induced tumorigenesis
- (2010) A. Nabeyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling
- (2009) C. Yang et al. CANCER RESEARCH
- Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
- (2008) Nicolai E Savaskan et al. NATURE MEDICINE
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