Epigenetic regulation of epithelial–mesenchymal transition

Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance

(2016) A. Krumm et al.   CANCER RESEARCH

Mechanisms of long noncoding RNA function in development and disease

(2016) Sandra U. Schmitz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis

(2016) Sonam Dhamija et al.   INTERNATIONAL JOURNAL OF CANCER

Epigenetic regulation of E-cadherin expression by the histone demethylase UTX in colon cancer cells

(2016) Lin Zha et al.   MEDICAL ONCOLOGY

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1

(2016) Jacob I Stuckey et al.   Nature Chemical Biology

Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance

(2016) Molly Gale et al.   Oncotarget

HDAC1 promoted migration and invasion binding with TCF12 by promoting EMT progress in gallbladder cancer

(2016) Junyi He et al.   Oncotarget

Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis

(2016) Carla Regina et al.   Oncotarget

The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1

(2016) Yanyan Gao et al.   Scientific Reports

MicroRNA Regulation of Epithelial to Mesenchymal Transition

(2016) Mohammed Abba et al.   Journal of Clinical Medicine

DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression

(2015) Xianghong Ning et al.   CANCER LETTERS

TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation

(2015) D. J. Drasin et al.   CANCER RESEARCH

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

(2015) S. Meidhof et al.   EMBO Molecular Medicine

MPP8 and SIRT1 crosstalk in E-cadherin gene silencing and epithelial-mesenchymal transition

(2015) L. Sun et al.   EMBO REPORTS

UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

(2015) H.-J. Choi et al.   EMBO REPORTS

SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3

(2015) Yoshimi Shinchi et al.   EXPERIMENTAL CELL RESEARCH

Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation

(2015) Nilotpal Roy et al.   GENES & DEVELOPMENT

BRD4 Inhibitor Inhibits Colorectal Cancer Growth and Metastasis

(2015) Yuan Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long Non-coding RNAs (LncRNA) Regulated by Transforming Growth Factor (TGF) β

(2015) Edward J. Richards et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SET8 induces epithelial-mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1

(2015) LIEJUN HOU et al.   Molecular Medicine Reports

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Sound of silence: the properties and functions of repressive Lys methyltransferases

(2015) Chiara Mozzetta et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin

(2015) Rui Xia et al.   TUMOR BIOLOGY

DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

(2015) Min-Hyung Cho et al.   Nature Communications

Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53

(2015) Qi Fei et al.   Nature Communications

Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer

(2015) Nidhi Bansal et al.   Oncotarget

Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit

(2015) Xiuming Liang et al.   Oncotarget

JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells

(2015) Bo Tang et al.   Oncotarget

Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression

(2015) Honghe Wang et al.   Oncotarget

Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma

(2015) Min Zheng et al.   Oncotarget

G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma

(2015) Shuli Liu et al.   Oncotarget

G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation

(2015) Mei-Ren Pan et al.   Scientific Reports

Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

(2015) C. Kadoch et al.   Science Advances

The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

(2015) Andrew E. Tee et al.   Oncotarget

Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer

(2015) Li Zhang et al.   Oncotarget

Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer

(2014) Jian Shi et al.   CANCER CELL

H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis

(2014) P.-C. Wu et al.   CANCER RESEARCH

A Comprehensive DNA Methylation Profile of Epithelial-to-Mesenchymal Transition

(2014) F. J. Carmona et al.   CANCER RESEARCH

PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer

(2014) R. Yao et al.   CANCER RESEARCH

UTX and MLL4 Coordinately Regulate Transcriptional Programs for Cell Proliferation and Invasiveness in Breast Cancer Cells

(2014) Jae-Hwan Kim et al.   CANCER RESEARCH

Small Molecule Control of Chromatin Remodeling

(2014) Aidan Finley et al.   CHEMISTRY & BIOLOGY

Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation

(2014) Tobias Wagner et al.   ChemMedChem

Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas

(2014) Jacqueline Jones et al.   CLINICAL & EXPERIMENTAL METASTASIS

Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition

(2014) Reem Ibrahim et al.   HUMAN PATHOLOGY

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

(2014) Junwei Shi et al.   MOLECULAR CELL

The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

(2014) E-Jean Tan et al.   NUCLEIC ACIDS RESEARCH

MiR-7, Inhibited Indirectly by LincRNA HOTAIR, Directly Inhibits SETDB1 and Reverses the EMT of Breast Cancer Stem Cells by Downregulating the STAT3 Pathway

(2014) Hongyi Zhang et al.   STEM CELLS

A Brief History of Epigenetics

(2014) G. Felsenfeld   Cold Spring Harbor Perspectives in Biology

LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis

(2014) P Hou et al.   Cell Death & Disease

Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis

(2014) Jian Cao et al.   Cell Reports

δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells

(2014) Akihiko Fukagawa et al.   Cancer Medicine

The role of chromatin modifiers in normal and malignant hematopoiesis

(2013) J. S. Butler et al.   BLOOD

Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin

(2013) Preeti Shah et al.   BREAST CANCER RESEARCH AND TREATMENT

Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis

(2013) Y.-C. Teng et al.   CANCER RESEARCH

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family

(2013) Zanabazar Enkhbaatar et al.   CELL CYCLE

JMJD2B Promotes Epithelial-Mesenchymal Transition by Cooperating with  -Catenin and Enhances Gastric Cancer Metastasis

(2013) L. Zhao et al.   CLINICAL CANCER RESEARCH

Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step

(2013) Kiranmai Gumireddy et al.   EMBO JOURNAL

Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family

(2013) Yu Yu et al.   INTERNATIONAL JOURNAL OF CANCER

The Malignant Brain Tumor (MBT) Domain Protein SFMBT1 Is an Integral Histone Reader Subunit of the LSD1 Demethylase Complex for Chromatin Association and Epithelial-to-mesenchymal Transition

(2013) Ming Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SWI/SNF Chromatin-Remodeling Factor Smarcd3/Baf60c Controls Epithelial-Mesenchymal Transition by Inducing Wnt5a Signaling

(2013) N. V. Jordan et al.   MOLECULAR AND CELLULAR BIOLOGY

A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation

(2013) Kaitlyn E. Moore et al.   MOLECULAR CELL

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

(2013) Lindsey I James et al.   Nature Chemical Biology

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex

(2013) John R Prensner et al.   NATURE GENETICS

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Histone lysine demethylases as targets for anticancer therapy

(2013) Jonas W. Højfeldt et al.   NATURE REVIEWS DRUG DISCOVERY

Transcriptional regulation by Polycomb group proteins

(2013) Luciano Di Croce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA methylation dynamics in health and disease

(2013) Yehudit Bergman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis

(2013) M Rodriguez-Paredes et al.   ONCOGENE

Multilayer control of the EMT master regulators

(2013) H Zheng et al.   ONCOGENE

A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

(2013) Lei Wang et al.   Nature Communications

Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition

(2013) Gabriel G Malouf et al.   GENOME BIOLOGY

The mutational landscape of chromatin regulatory factors across 4,623 tumor samples

(2013) Abel Gonzalez-Perez et al.   GENOME BIOLOGY

Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells

(2013) Joëlle Roche et al.   Cancers

Nuclear Kaiso Indicates Aggressive Prostate Cancers and Promotes Migration and Invasiveness of Prostate Cancer Cells

(2012) Jacqueline Jones et al.   AMERICAN JOURNAL OF PATHOLOGY

Programming of DNA Methylation Patterns

(2012) Howard Cedar et al.   Annual Review of Biochemistry

Histone deacetylase inhibitor induction of epithelial–mesenchymal transitions via up-regulation of Snail facilitates cancer progression

(2012) Guan-Min Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibiting Interactions of Lysine Demethylase LSD1 with Snail/Slug Blocks Cancer Cell Invasion

(2012) G. Ferrari-Amorotti et al.   CANCER RESEARCH

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Cancer epigenomics: beyond genomics

(2012) Juan Sandoval et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4

(2012) S. S. Dhar et al.   GENES & DEVELOPMENT

Histone Demethylase KDM6B Promotes Epithelial-Mesenchymal Transition

(2012) Sivakumar Ramadoss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP)

(2012) Beiyun Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A PHD12–Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition

(2012) Pablo H. Strobl-Mazzulla et al.   JOURNAL OF CELL BIOLOGY

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

(2012) Chenfang Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone Recognition by Human Malignant Brain Tumor Domains

(2012) Nataliya Nady et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer

(2012) C Dong et al.   ONCOGENE

Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

(2012) P Dong et al.   ONCOGENE

Cooperation of p300 and PCAF in the Control of MicroRNA 200c/141 Transcription and Epithelial Characteristics

(2012) Yoshiaki Mizuguchi et al.   PLoS One

Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer

(2012) Tangfeng Lv et al.   PLoS One

Histone Deacetylase Inhibitors Induce Epithelial-to-Mesenchymal Transition in Prostate Cancer Cells

(2012) Dejuan Kong et al.   PLoS One

PRC2/EED-EZH2 Complex Is Up-Regulated in Breast Cancer Lymph Node Metastasis Compared to Primary Tumor and Correlates with Tumor Proliferation In Situ

(2012) Hongxiang Yu et al.   PLoS One

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

Binding of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells by Repressing Chemokine CCL14

(2011) Q. Li et al.   CANCER RESEARCH

Snail2 is an Essential Mediator of Twist1-Induced Epithelial Mesenchymal Transition and Metastasis

(2011) E. Casas et al.   CANCER RESEARCH

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

MicroRNAs as regulators of epithelial-mesenchymal transition

(2011) Philip A. Gregory et al.   CELL CYCLE

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

(2011) Fen Yang et al.   EMBO JOURNAL

Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer

(2011) Ali Aghdassi et al.   GUT

miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Cooperation between Snail1 and Twist in the Regulation ofZEB1Expression during Epithelial to Mesenchymal Transition

(2011) Natàlia Dave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

(2011) Nam Hee Kim et al.   JOURNAL OF CELL BIOLOGY

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Insights for MPP8 Chromodomain Interaction with Histone H3 Lysine 9: Potential Effect of Phosphorylation on Methyl-Lysine Binding

(2011) Yanqi Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SUV420H2-Mediated H4K20 Trimethylation Enforces RNA Polymerase II Promoter-Proximal Pausing by Blocking hMOF-Dependent H4K16 Acetylation

(2011) P. Kapoor-Vazirani et al.   MOLECULAR AND CELLULAR BIOLOGY

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition

(2011) Min-Zu Wu et al.   MOLECULAR CELL

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

(2011) Masoud Vedadi et al.   Nature Chemical Biology

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition

(2011) Oliver G McDonald et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion

(2011) M Björkman et al.   ONCOGENE

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

(2011) V Davalos et al.   ONCOGENE

The Transcription Factors Snail and Slug Activate the Transforming Growth Factor-Beta Signaling Pathway in Breast Cancer

(2011) Archana Dhasarathy et al.   PLoS One

Structural Basis for Specific Binding of Human MPP8 Chromodomain to Histone H3 Methylated at Lysine 9

(2011) Jing Li et al.   PLoS One

Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression

(2011) Q. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation

(2011) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

(2011) L. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a

(2011) Yanqi Chang et al.   Nature Communications

Coordinated Chromatin Control: Structural and Functional Linkage of DNA and Histone Methylation

(2010) Xiaodong Cheng et al.   BIOCHEMISTRY

Smad Signaling Is Required to Maintain Epigenetic Silencing during Breast Cancer Progression

(2010) P. Papageorgis et al.   CANCER RESEARCH

H3K9 Histone Methyltransferase G9a Promotes Lung Cancer Invasion and Metastasis by Silencing the Cell Adhesion Molecule Ep-CAM

(2010) M.-W. Chen et al.   CANCER RESEARCH

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis

(2010) Junjiang Fu et al.   CELL RESEARCH

Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion

(2010) Kenji Kokura et al.   EMBO JOURNAL

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1

(2010) Yiwei Lin et al.   EMBO JOURNAL

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer

(2010) Erik D. Wiklund et al.   INTERNATIONAL JOURNAL OF CANCER

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

(2010) Arunkumar Dhayalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MS-275 Sensitizes TRAIL-Resistant Breast Cancer Cells, Inhibits Angiogenesis and Metastasis, and Reverses Epithelial-Mesenchymal Transition In vivo

(2010) R. K. Srivastava et al.   MOLECULAR CANCER THERAPEUTICS

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

(2010) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

(2010) Li Ma et al.   NATURE CELL BIOLOGY

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

ERα signaling through slug regulates E-cadherin and EMT

(2010) Y Ye et al.   ONCOGENE

ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1

(2010) E Sánchez-Tilló et al.   ONCOGENE

Role for DNA Methylation in the Regulation of miR-200c and miR-141 Expression in Normal and Cancer Cells

(2010) Lukas Vrba et al.   PLoS One

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion

(2009) Hongping Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The multiple facets of histone H4-lysine 20 methylationThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

(2009) Hongbo Yang et al.   Biochemistry and Cell Biology

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

(2009) Otto Schmalhofer et al.   CANCER AND METASTASIS REVIEWS

Hijacking the Chromatin Remodeling Machinery: Impact of SWI/SNF Perturbations in Cancer

(2009) B. Weissman et al.   CANCER RESEARCH

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer

(2009) Yan Wang et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The role of microRNAs in metastasis and epithelial-mesenchymal transition

(2009) C. P. Bracken et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications

(2009) M. T. McCabe et al.   CLINICAL CANCER RESEARCH

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

Epigenetics and cancer treatment

(2009) Lasse Sommer Kristensen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

(2009) Yanqi Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics

(2009) A. M. Quinn et al.   NUCLEIC ACIDS RESEARCH

Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition

(2009) A Lakshmikuttyamma et al.   ONCOGENE

Epigenome Microarray Platform for Proteome-Wide Dissection of Chromatin-Signaling Networks

(2009) Dennis J. Bua et al.   PLoS One

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

Role of hMOF-Dependent Histone H4 Lysine 16 Acetylation in the Maintenance of TMS1/ASC Gene Activity

(2008) P. Kapoor-Vazirani et al.   CANCER RESEARCH

Crosstalk among Histone Modifications

(2008) Tamaki Suganuma et al.   CELL

Ajuba LIM Proteins Are Snail/Slug Corepressors Required for Neural Crest Development in Xenopus

(2008) Ellen M. Langer et al.   DEVELOPMENTAL CELL

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2

(2008) Manav Korpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

30 nm Chromatin Fibre Decompaction Requires both H4-K16 Acetylation and Linker Histone Eviction

(2008) Philip J.J. Robinson et al.   JOURNAL OF MOLECULAR BIOLOGY

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

(2008) N. Herranz et al.   MOLECULAR AND CELLULAR BIOLOGY

The LIM Protein AJUBA Recruits Protein Arginine Methyltransferase 5 To Mediate SNAIL-Dependent Transcriptional Repression

(2008) Z. Hou et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

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