Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family

Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling

(2012) Yu Yu et al.   EMBO REPORTS

Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer

(2012) E J H Wee et al.   ONCOGENE

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

(2011) V Davalos et al.   ONCOGENE

The role of the miR-200 family in epithelial-mesenchymal transition

(2010) Perry S. Mongroo et al.   CANCER BIOLOGY & THERAPY

Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death

(2010) Xiaowei Gong et al.   CANCER LETTERS

Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration

(2010) Zhengwen An et al.   INTERNATIONAL JOURNAL OF CANCER

miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1

(2010) J. D. Roybal et al.   MOLECULAR CANCER RESEARCH

Role for DNA Methylation in the Regulation of miR-200c and miR-141 Expression in Normal and Cancer Cells

(2010) Lukas Vrba et al.   PLoS One

Structure and activity of putative intronic miRNA promoters

(2010) A. M. Monteys et al.   RNA

Epigenetic architecture and miRNA: reciprocal regulators

(2010) Erik D Wiklund et al.   Epigenomics

Proliferating Cell Nuclear Antigen Is Protected from Degradation by Forming a Complex with MutT Homolog2

(2009) Yu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

Chromatin structure analyses identify miRNA promoters

(2008) F. Ozsolak et al.   GENES & DEVELOPMENT

Histone Deacetylase Inhibitor Depsipeptide Activates Silenced Genes through Decreasing both CpG and H3K9 Methylation on the Promoter

(2008) L.-P. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

A Suppressive Role of Mitogen Inducible Gene-2 in Mesenchymal Cancer Cell Invasion

(2008) X. Shi et al.   MOLECULAR CANCER RESEARCH

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY