Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation

Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint

(2013) Laifeng Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

(2013) Christian Bronner et al.   BIOCHEMICAL PHARMACOLOGY

CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1

(2013) Sang Hyup Lee et al.   CANCER LETTERS

NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma

(2013) Z. Huang et al.   CANCER RESEARCH

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

(2013) Feng Li et al.   CELL

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation

(2013) Yi-Bo Luo et al.   CELL CYCLE

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline

(2013) Jonathan P Saxe et al.   EMBO JOURNAL

Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis

(2013) Humberto J Ferreira et al.   Epigenetics

WD40 repeat-containing 62 overexpression as a novel indicator of poor prognosis for human gastric cancer

(2013) Shan Zeng et al.   EUROPEAN JOURNAL OF CANCER

SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors

(2013) J. Zhang et al.   GENES & DEVELOPMENT

The Malignant Brain Tumor (MBT) Domain Protein SFMBT1 Is an Integral Histone Reader Subunit of the LSD1 Demethylase Complex for Chromatin Association and Epithelial-to-mesenchymal Transition

(2013) Ming Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3

(2013) M. Sabra et al.   JOURNAL OF CELL SCIENCE

Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3

(2013) Lindsey I. James et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Making of I-BET762, a BET Bromodomain Inhibitor Now in Clinical Development

(2013) Yujun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human heterochromatin protein 1 isoforms regulate androgen receptor signaling in prostate cancer

(2013) Momoe Itsumi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1–BCR-ABL–JAK2 Complex

(2013) Min Chen et al.   JNCI-Journal of the National Cancer Institute

NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern

(2013) J D E de Rooij et al.   LEUKEMIA

Stk31is dispensable for embryonic development and spermatogenesis in mice

(2013) Jianqiang Bao et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

(2013) Lindsey I James et al.   Nature Chemical Biology

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

(2013) Jacob D Jaffe et al.   NATURE GENETICS

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

(2013) Jocelyn O. Eidahl et al.   NUCLEIC ACIDS RESEARCH

ERG Induces Epigenetic Activation of Tudor Domain-Containing Protein 1 (TDRD1) in ERG Rearrangement-Positive Prostate Cancer

(2013) Lukasz A. Kacprzyk et al.   PLoS One

Epigenetic Regulation of Myogenic Gene Expression by Heterochromatin Protein 1 Alpha

(2013) Patima Sdek et al.   PLoS One

A Method for WD40 Repeat Detection and Secondary Structure Prediction

(2013) Yang Wang et al.   PLoS One

A Tudor Domain Protein SPINDLIN1 Interacts with the mRNA-Binding Protein SERBP1 and Is Involved in Mouse Oocyte Meiotic Resumption

(2013) Ting Gang Chew et al.   PLoS One

Tudor: a versatile family of histone methylation ‘readers’

(2013) Rui Lu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of Hepatoma-Derived Growth Factor as a Potential Prognostic and Diagnostic Marker for Extrahepatic Cholangiocarcinoma

(2013) Yuxia Han et al.   WORLD JOURNAL OF SURGERY

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

(2013) Yuri Bolshan et al.   ACS Medicinal Chemistry Letters

Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain

(2013) Rick van Nuland et al.   Epigenetics & Chromatin

Overexpression of WDR62 is associated with centrosome amplification in human ovarian cancer

(2013) Yu Zhang et al.   Journal of Ovarian Research

COM-1 Promotes Homologous Recombination during Caenorhabditis elegans Meiosis by Antagonizing Ku-Mediated Non-Homologous End Joining

(2013) Bennie B. L. G. Lemmens et al.   PLoS Genetics

Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3

(2012) Su Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

(2012) Guillermo Senisterra et al.   BIOCHEMICAL JOURNAL

Multivalent Recognition of Histone Tails by the PHD Fingers of CHD5

(2012) Samuel S. Oliver et al.   BIOCHEMISTRY

Identification and Characterization of Small Molecule Inhibitors of a Plant Homeodomain Finger

(2012) Elise K. Wagner et al.   BIOCHEMISTRY

ChromoHub: a data hub for navigators of chromatin-mediated signalling

(2012) L. Liu et al.   BIOINFORMATICS

Small-Molecule Inhibition of BRDT for Male Contraception

(2012) Martin M. Matzuk et al.   CELL

The MOF Chromobarrel Domain Controls Genome-wide H4K16 Acetylation and Spreading of the MSL Complex

(2012) Thomas Conrad et al.   DEVELOPMENTAL CELL

On WD40 proteins: Propelling our knowledge of transcriptional control?

(2012) Valentina Migliori et al.   Epigenetics

Structural biology of the chromodomain: Form and function

(2012) Joel C. Eissenberg   GENE

Mutation update on the CHD7 gene involved in CHARGE syndrome

(2012) Nicole Janssen et al.   HUMAN MUTATION

Nuclear Factor-κB (NF-κB) Regulates the Expression of Human Testis-Enriched Leucine-Rich Repeats and WD Repeat Domain Containing 1 (LRWD1) Gene

(2012) Yen-Ni Teng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leucine-rich Repeat and WD Repeat-containing Protein 1 Is Recruited to Pericentric Heterochromatin by Trimethylated Lysine 9 of Histone H3 and Maintains Heterochromatin Silencing

(2012) Kui Ming Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insight into Recognition of Methylated Histone Tails by Retinoblastoma-binding Protein 1

(2012) Weibin Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lamin B Receptor Recognizes Specific Modifications of Histone H4 in Heterochromatin Formation

(2012) Yasuhiro Hirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition

(2012) Chao He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Histone Methyltransferase MMSET Regulates Class Switch Recombination

(2012) H. Pei et al.   JOURNAL OF IMMUNOLOGY

Histone Recognition by Human Malignant Brain Tumor Domains

(2012) Nataliya Nady et al.   JOURNAL OF MOLECULAR BIOLOGY

Hinge and Chromoshadow of HP1α Participate in Recognition of K9 Methylated Histone H3 in Nucleosomes

(2012) Yuichi Mishima et al.   JOURNAL OF MOLECULAR BIOLOGY

Overexpression of MMSET in endometrial cancer: A clinicopathologic study

(2012) Min Xiao et al.   JOURNAL OF SURGICAL ONCOLOGY

High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

(2012) Hacer Karatas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC

(2012) D-J Min et al.   LEUKEMIA

The Stress Oncoprotein LEDGF/p75 Interacts with the Methyl CpG Binding Protein MeCP2 and Influences Its Transcriptional Activity

(2012) L. S. Leoh et al.   MOLECULAR CANCER RESEARCH

SPINDLIN1 Promotes Cancer Cell Proliferation through Activation of WNT/TCF-4 Signaling

(2012) J.-X. Wang et al.   MOLECULAR CANCER RESEARCH

LEDGF (p75) promotes DNA-end resection and homologous recombination

(2012) Mads Daugaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

(2012) Valentina Migliori et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

(2012) Pamela Zhang et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30

(2012) Ke Liu et al.   PLoS One

Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association Study

(2012) Hsin-Chou Yang et al.   PLoS One

Novel Fusion of MYST/Esa1-Associated Factor 6 and PHF1 in Endometrial Stromal Sarcoma

(2012) Ioannis Panagopoulos et al.   PLoS One

The Histone H4 Lysine 20 Monomethyl Mark, Set by PR-Set7 and Stabilized by L(3)mbt, Is Necessary for Proper Interphase Chromatin Organization

(2012) Ayako Sakaguchi et al.   PLoS One

Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes

(2012) Y.-Q. Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1

(2012) N. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing

(2012) Madapura M. Pradeepa et al.   PLoS Genetics

Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B

(2011) Xue Guo et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Chromobox Protein Homolog 3 Is Essential for Stem Cell Differentiation to Smooth Muscles In Vitro and in Embryonic Arteriogenesis

(2011) Qingzhong Xiao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA

(2011) Yu Qiu et al.   BIOCHEMICAL JOURNAL

Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription

(2011) Kyoko L. Yap et al.   BIOCHEMISTRY

Cancers and the NSD family of histone lysine methyltransferases

(2011) Masayo Morishita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Readers of histone modifications

(2011) Miyong Yun et al.   CELL RESEARCH

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors

(2011) H. R. Hudlebusch et al.   CLINICAL CANCER RESEARCH

The Expression and Prognostic Role of Hepatoma-Derived Growth Factor in Colorectal Stromal Tumors

(2011) Tsung-Hui Hu et al.   DISEASES OF THE COLON & RECTUM

Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes

(2011) Weixiang Wang et al.   EMBO REPORTS

Chromodomain helicase DNA-binding protein 2 affects the repair of X-ray and UV-Induced DNA damage

(2011) Sangeetha Rajagopalan et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genetic and expressional alterations of CHD genes in gastric and colorectal cancers

(2011) Min Sung Kim et al.   HISTOPATHOLOGY

Chromatin-modifying Complex Component Nurf55/p55 Associates with Histones H3 and H4 and Polycomb Repressive Complex 2 Subunit Su(z)12 through Partially Overlapping Binding Sites

(2011) Agnieszka J. Nowak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of free energy predictors for ligand binding to a methyllysine histone code reader

(2011) Cen Gao et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Druggability of methyl-lysine binding sites

(2011) C. Santiago et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Small-Molecule Ligands of Methyl-Lysine Binding Proteins

(2011) J. Martin Herold et al.   JOURNAL OF MEDICINAL CHEMISTRY

UHRF1 Double Tudor Domain and the Adjacent PHD Finger Act Together to Recognize K9me3-Containing Histone H3 Tail

(2011) Si Xie et al.   JOURNAL OF MOLECULAR BIOLOGY

Biophysical Probes Reveal a “Compromise” Nature of the Methyl-lysine Binding Pocket in L3MBTL1

(2011) Cen Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Histone Methylation by PRC2 Is Inhibited by Active Chromatin Marks

(2011) Frank W. Schmitges et al.   MOLECULAR CELL

Recognition of enhancer element–specific histone methylation by TIP60 in transcriptional activation

(2011) Kwang Won Jeong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and Histone Binding Ability Characterizations of Human PWWP Domains

(2011) Hong Wu et al.   PLoS One

Cell surface heparan sulfates mediate internalization of the PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signalling processes involved in fibroblast cell migration

(2010) Chia-Hui Wang et al.   BIOCHEMICAL JOURNAL

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera

(2010) F. Perna et al.   BLOOD

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

(2010) Till Bartke et al.   CELL

Keeping it in the family: diverse histone recognition by conserved structural folds

(2010) Kyoko L. Yap et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes

(2010) Radhika A Varier et al.   EMBO JOURNAL

How does the Royal Family of Tudor rule the PIWI-interacting RNA pathway?

(2010) M. C. Siomi et al.   GENES & DEVELOPMENT

The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression

(2010) Lisandra E. West et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Biochemical Studies on the Chromo-barrel Domain of Male Specific Lethal 3 (MSL3) Reveal a Binding Preference for Mono- or Dimethyllysine 20 on Histone H4

(2010) Stanley A. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition and Specificity Determinants of the Human Cbx Chromodomains

(2010) Lilia Kaustov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

(2010) Arunkumar Dhayalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Non-Peptide Malignant Brain Tumor (MBT) Repeat Antagonists by Virtual Screening of Commercially Available Compounds

(2010) Dmitri Kireev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Insight into p53 Recognition by the 53BP1 Tandem Tudor Domain

(2010) Siddhartha Roy et al.   JOURNAL OF MOLECULAR BIOLOGY

PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription

(2010) K. Fortschegger et al.   MOLECULAR AND CELLULAR BIOLOGY

A WD-Repeat Protein Stabilizes ORC Binding to Chromatin

(2010) Zhen Shen et al.   MOLECULAR CELL

Finding Inspiration in the Protein Data Bank to Chemically Antagonize Readers of the Histone Code

(2010) Valérie Campagna-Slater et al.   Molecular Informatics

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting epigenetic modifiers: Inhibitors of histone methyltransferases

(2010) Elisabeth-Maria Bissinger et al.   MedChemComm

Ovaries and Female Phenotype in a Girl with 46,XY Karyotype and Mutations in the CBX2 Gene

(2009) Anna Biason-Lauber et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Hepatoma-derived Growth Factor Represses SET and MYND Domain Containing 1 Gene Expression through Interaction with C-terminal Binding Protein

(2009) Jun Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of Set9-Mediated H4K20 Methylation by a PWWP Domain Protein

(2009) Yu Wang et al.   MOLECULAR CELL

A small-cell lung cancer genome with complex signatures of tobacco exposure

(2009) Erin D. Pleasance et al.   NATURE

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

Role of the polycomb protein EED in the propagation of repressive histone marks

(2009) Raphael Margueron et al.   NATURE

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming

(2009) Sylvain Daujat et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis

(2009) P Nagarajan et al.   ONCOGENE

Structural Studies of a Four-MBT Repeat Protein MBTD1

(2009) Jitka Eryilmaz et al.   PLoS One

MBT domain proteins in development and disease

(2009) Roberto Bonasio et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human Mismatch Repair Protein MSH6 Contains a PWWP Domain That Targets Double Stranded DNA†

(2008) Cédric Laguri et al.   BIOCHEMISTRY

Overexpression of SPINDLIN1 induces cellular senescence, multinucleation and apoptosis

(2008) Hongfeng Yuan et al.   GENE

MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells

(2008) J. L.R. Brito et al.   HAEMATOLOGICA

Structure of WDR5 Bound to Mixed Lineage Leukemia Protein-1 Peptide

(2008) Anamika Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of spindlin1 induces metaphase arrest and chromosomal instability

(2008) Peng Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Heterochromatin Protein 1 Family is Regulated in Prostate Development and Cancer

(2008) Ellen Shapiro et al.   JOURNAL OF UROLOGY

Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity

(2008) M.-C. Shun et al.   JOURNAL OF VIROLOGY

PHD fingers in human diseases: Disorders arising from misinterpreting epigenetic marks

(2008) Lindsey A. Baker et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

(2008) N Kalakonda et al.   ONCOGENE