Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways

Designing a new dimerized anti human TNF‐α aptamer with blocking activity

(2020) Kazem Mashayekhi et al.   BIOTECHNOLOGY PROGRESS

V617F‐independent upregulation of JAK2 gene expression in patients with inflammatory bowel disease

(2019) Hamid Asadzadeh‐Aghdaei et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Simvastatin Suppresses Interleukin Iβ Release in Human Peripheral Blood Mononuclear Cells Stimulated With Cholesterol Crystals

(2018) Anna J. Boland et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Are toll-like receptors potential drug targets for atherosclerosis? Evidence from genetic studies to date

(2018) Christopher P. Nelson et al.   IMMUNOGENETICS

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Role of NLRP3 Inflammasomes in Atherosclerosis

(2017) Tadayoshi Karasawa et al.   Journal of Atherosclerosis and Thrombosis

Overexpression of Toll-Like Receptors 2, 3, 4, and 8 Is Correlated to the Vascular Atherosclerotic Process in the Hyperlipidemic Rabbit Model: The Effect of Statin Treatment

(2017) Alkistis Kapelouzou et al.   JOURNAL OF VASCULAR RESEARCH

Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes

(2017) Zhen-Huan Lv et al.   Oncotarget

NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy

(2017) Beibei Luo et al.   Frontiers in Physiology

Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms

(2016) Piotr Chruściel et al.   ATHEROSCLEROSIS

Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes

(2016) Fanqi Kong et al.   BIOMEDICINE & PHARMACOTHERAPY

Ticagrelor and Rosuvastatin Have Additive Cardioprotective Effects via Adenosine

(2016) Yochai Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

From C-Reactive Protein to Interleukin-6 to Interleukin-1

(2016) Paul M Ridker   CIRCULATION RESEARCH

Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse

(2016) Stefano Toldo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The role of the inflammasome in patients with autoinflammatory diseases

(2016) Hal M. Hoffman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

The impact of statin therapy on plasma levels of von Willebrand factor antigen

(2016) Amirhossein Sahebkar et al.   THROMBOSIS AND HAEMOSTASIS

NOD-Like Receptors in Infection, Immunity, and Diseases

(2016) Young Keun Kim et al.   YONSEI MEDICAL JOURNAL

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

(2016) Geena Paramel Varghese et al.   Journal of the American Heart Association

Oxidized Low‐Density Lipoprotein (OxLDL)–Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let‐7c Is Integral to the Effect

(2016) Johan Frostegård et al.   Journal of the American Heart Association

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Platelet P2Y12Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human ModelSignificance

(2015) Mark R. Thomas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Statin therapy reduces plasma endothelin-1 concentrations: A meta-analysis of 15 randomized controlled trials

(2015) Amirhossein Sahebkar et al.   ATHEROSCLEROSIS

Circulating Toll-like receptor 4-responsive microRNA panel in patients with coronary artery disease: results from prospective and randomized study of treatment with renin–angiotensin system blockade

(2015) Mamoru Satoh et al.   CLINICAL SCIENCE

NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins

(2015) Afrasyab Altaf et al.   CORONARY ARTERY DISEASE

Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development inLdlr−/−mice

(2015) Tim Hendrikx et al.   FEBS Journal

Simvastatin protects the heart against ischemia reperfusion injury via inhibiting HMGB1 expression through PI3K/Akt signal pathways

(2015) Qian-Feng Han et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation

(2015) KUANG PENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

(2015) Marc P. Bonaca et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipids, blood pressure and kidney update 2014

(2015) Maciej Banach et al.   PHARMACOLOGICAL RESEARCH

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Is immunity a mechanism contributing to statin-induced diabetes?

(2015) Brandyn D Henriksbo et al.   Adipocyte

Chronic Treatment With Ticagrelor Limits Myocardial Infarct Size

(2014) Manjyot K. Nanhwan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atorvastatin attenuates myocardial remodeling induced by chronic intermittent hypoxia in rats: Partly involvement of TLR-4/MYD88 pathway

(2014) Xiao Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis

(2014) Z. Ding et al.   CARDIOVASCULAR RESEARCH

Statin-Induced Insulin Resistance Through Inflammasome Activation: Sailing Between Scylla and Charybdis

(2014) Patricia Mitchell et al.   DIABETES

Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance

(2014) Brandyn D. Henriksbo et al.   DIABETES

3-Hydroxyl-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor (Statin)-induced 28-kDa Interleukin-1β Interferes with Mature IL-1β Signaling

(2014) Facundo Davaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

(2014) Fei Zheng et al.   MEDIATORS OF INFLAMMATION

Rosuvastatin Alleviates Diabetic Cardiomyopathy by Inhibiting NLRP3 Inflammasome and MAPK Pathways in a Type 2 Diabetes Rat Model

(2013) Beibei Luo et al.   CARDIOVASCULAR DRUGS AND THERAPY

New Therapies Targeting apoB Metabolism for High-Risk Patients with Inherited Dyslipidaemias: What Can the Clinician Expect?

(2013) Amirhossein Sahebkar et al.   CARDIOVASCULAR DRUGS AND THERAPY

NLRP3 inflammasome activation in coronary artery disease: results from prospective and randomized study of treatment with atorvastatin or rosuvastatin

(2013) Mamoru Satoh et al.   CLINICAL SCIENCE

The lectin-like oxidized low-density lipoprotein receptor-1 as therapeutic target for atherosclerosis, inflammatory conditions and longevity

(2013) Gudrun Ulrich-Merzenich et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

LOX-1, OxLDL, and Atherosclerosis

(2013) Angela Pirillo et al.   MEDIATORS OF INFLAMMATION

Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence

(2013) Daniela Volonte et al.   MOLECULAR BIOLOGY OF THE CELL

Effect of atorvastatin on expression of TLR4 and NF-κB p65 in atherosclerotic rabbits

(2013) Ding-Zhu Shen et al.   Asian Pacific Journal of Tropical Medicine

Statins and Pulmonary Fibrosis

(2012) Jin-Fu Xu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of simvastatin or its combination with ezetimibe on Toll-like receptor expression and lipopolysaccharide – Induced cytokine production in monocytes of hypercholesterolemic patients

(2012) Elisavet Moutzouri et al.   ATHEROSCLEROSIS

Effects of HMG-CoA Reductase Inhibitor on Experimental Autoimmune Myocarditis

(2012) Xiaoman Liu et al.   CARDIOVASCULAR DRUGS AND THERAPY

Atorvastatin decreases Toll-like receptor 4 expression and downstream signaling in human monocytic leukemia cells

(2012) Shuan Suo Yang et al.   CELLULAR IMMUNOLOGY

Novel Aspects of Mevalonate Pathway Inhibitors as Antitumor Agents

(2012) M. Thurnher et al.   CLINICAL CANCER RESEARCH

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy

(2012) M. Rajesh et al.   DIABETES

Rosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myocardial infarction in rats: Role of iNOS and VEGF

(2012) Sawsan A. Zaitone et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The therapeutic effect of Rosuvastatin on cardiac remodelling from hypertrophy to fibrosis during the end-stage hypertension in rats

(2012) W.B. Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

(2012) Y.-H. Liao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Statins as potential therapeutic drug for asthma?

(2012) Cheng Yuan et al.   RESPIRATORY RESEARCH

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice

(2011) Vinay Bhaskar et al.   ATHEROSCLEROSIS

Rosuvastatin improves endothelial function indb/dbmice: role of angiotensin II type 1 receptors and oxidative stress

(2011) XY Tian et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model

(2011) Yun Ti et al.   DIABETES

The effects of atorvastatin and rosuvastatin on oxidative stress in diabetic patients

(2011) Murat Koksal et al.   European Journal of Internal Medicine

Effect of atorvastatin with or without prednisolone on Freund's adjuvant induced-arthritis in rats

(2011) Amany A. Abdin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: Effect of statins on let-7i and Toll-like receptor 4 signal

(2011) Mamoru Satoh et al.   IMMUNOBIOLOGY

The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

(2011) Qing Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction

(2011) Gemma Vilahur et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Simvastatin Therapy Reduces Prooxidant-Antioxidant Balance: Results of a Placebo-Controlled Cross-Over Trial

(2011) Seyyed M. R. Parizadeh et al.   LIPIDS

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Anti-inflammatory therapeutics for the treatment of atherosclerosis

(2011) Israel F. Charo et al.   NATURE REVIEWS DRUG DISCOVERY

Statin treatment is associated with reduced toll-like receptor 4 immunohistochemical expression on carotid atherosclerotic plaques: a novel effect of statins

(2011) Athanasios Katsargyris et al.   Vascular

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

(2011) P Menu et al.   Cell Death & Disease

Pretreatment with statins improves early outcome in patients with first-ever ischaemic stroke: a pleiotropic effect of statins or a beneficial effect of hypercholesterolemia?

(2010) Adrià Arboix et al.   BMC Neurology

The Alternative Pathway Is Critical for Pathogenic Complement Activation in Endotoxin- and Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

(2010) Talat H. Malik et al.   CIRCULATION

Expression ofmiR-146a/bis associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin–angiotensin system blockade and statins onmiRNA-146a/band Toll-like receptor 4 levels

(2010) Yuji Takahashi et al.   CLINICAL SCIENCE

Atorvastatin affects TLR4 clustering via lipid raft modulation

(2010) Praveen Chansrichavala et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation

(2010) George S. Abela   Journal of Clinical Lipidology

The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4

(2010) Jun Yang et al.   MOLECULAR BIOLOGY REPORTS

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Monocytes in atherosclerosis: subsets and functions

(2010) Kevin J. Woollard et al.   Nature Reviews Cardiology

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients With Acute Coronary and Cerebrovascular Syndromes

(2009) George S. Abela et al.   AMERICAN JOURNAL OF CARDIOLOGY

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Toll like receptor 4 in atherosclerosis and plaque destabilization

(2009) Wijnand K. den Dekker et al.   ATHEROSCLEROSIS

Lipoprotein Accumulation in Macrophages via Toll-Like Receptor-4–Dependent Fluid Phase Uptake

(2009) Soo-Ho Choi et al.   CIRCULATION RESEARCH

Innate immune signals in atherosclerosis

(2009) Anna M. Lundberg et al.   CLINICAL IMMUNOLOGY

Effect of Targeting Mitogen-Activated Protein Kinase on Cardiac Remodeling in Rats

(2009) Azza Baraka et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Therapeutic potential of statins in Alzheimer's disease

(2009) Nagaendran Kandiah et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atorvastatin Prevents Gentamicin-Induced Renal Damage in Rats through the Inhibition of p38-MAPK and NF-kB Pathways

(2009) Emin Ozbek et al.   RENAL FAILURE

The NLRP3 inflammasome: A sensor of immune danger signals

(2009) Suzanne L. Cassel et al.   SEMINARS IN IMMUNOLOGY

Prediction of long-term functional outcome in patients with acute ischemic non-embolic stroke

(2008) John Protopsaltis et al.   ATHEROSCLEROSIS

Statin synergizes with LPS to induce IL-1β release by THP-1 cells through activation of caspase-1

(2008) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY

Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression

(2008) Conrad P. Hodgkinson et al.   Pharmacogenetics and Genomics

CX 3 CR1 Deficiency Impairs Dendritic Cell Accumulation in Arterial Intima and Reduces Atherosclerotic Burden

(2007) Peng Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll-like receptor 4 gene (Asp299Gly) polymorphism associates with carotid artery elasticity

(2007) Jussi A. Hernesniemi et al.   ATHEROSCLEROSIS

Monocyte toll-like receptor 2 and 4 responses and expression following percutaneous coronary intervention: association with lesion stenosis and fractional flow reserve

(2007) D Versteeg et al.   HEART

Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure

(2007) Gábor Földes et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY